April 2023 in “Journal of Investigative Dermatology” In this study, using a mouse model, researchers found that inducing senescence in hair follicle stem cells led to hair regeneration failure and sebaceous gland enlargement, akin to androgenetic alopecia features.
58 citations
,
November 2012 in “PLoS ONE” This study found that dermal fibroblast cultures, especially those with higher alpha-smooth muscle actin expression, can be used to produce skin-derived precursor cells, unlike human hair follicle dermal papilla cultures.
March 2020 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” This study identified the dermal sheath as a driver of hair follicle regression through muscle contraction, essential for reuniting niches and stem cells to regenerate tissue structure during homeostasis.
268 citations
,
December 2003 in “Experimental Dermatology” This study demonstrated that clonal dermal papilla and dermal sheath cell lines from hair follicles can differentiate into lipid and bone cells, suggesting their potential as a stem cell source for tissue engineering.
December 2025 in “Preprints.org” This study examined dermal papilla cells from hair follicles, finding that gene expression changes linked to wound healing and stem cell activity align with hair follicle regression, which could inform strategies for hair growth and skin rejuvenation.
38 citations
,
April 2005 in “Journal of Investigative Dermatology” Human hair follicle cells can become fat and bone cells, useful for therapy.
March 2016 in “Benha Veterinary Medical Journal” This study investigated the gene Col19a1, finding its expression is specific to certain cells during hair follicle development in mice, suggesting its potential role in hair follicle morphogenesis.
30 citations
,
May 2018 in “Experimental Dermatology” This article reviews the cellular dynamics affecting dermal papilla size in androgenetic alopecia and suggests targeting DP size could improve therapies, but it presents no new clinical data.
11 citations
,
December 2018 in “Bone” This study found that a high-energy shock wave can increase osteogenic activities in human mesenchymal cells, offering insights into potential therapeutic targets for trauma-induced heterotopic ossification.
3 citations
,
January 2019 in “Advances in stem cells and their niches” This review discusses the role of dermal papilla cells in hair follicle morphogenesis and regeneration and reports no new results; the authors emphasize the importance of these cells in hair growth and pigmentation regulation.
November 2025 in “Journal of Investigative Dermatology” Estetrol may help prevent hair loss and support hair growth in women.
This study found that STAT5 activation and Sox18 are key in regulating hair follicle induction and cycling, while transducing SKPs with active STAT5B improved wound healing by reducing inflammation.
270 citations
,
March 2012 in “Dermatologic Surgery” This study found that autologous platelet-rich plasma increased hair growth potential by enhancing dermal papilla cell proliferation and stimulating key signaling pathways in both cell cultures and mice models.
December 1963 in “Medical Entomology and Zoology” This study found that Wnt1a overexpression from bone marrow mesenchymal stem cells enhanced hair follicle regeneration in mice by promoting the dermal papilla's role in hair cycling and gene expression recovery.
October 2022 in “Hair Transplantation” This study reviewed preliminary evidence suggesting platelet-rich plasma could play a significant role in hair restoration, with animal experiments showing faster hair cycle transitions compared to controls.
April 2016 in “Journal of Investigative Dermatology” The authors concluded that Wnt ligands produced by hair-inducing dermal papilla cells have crucial roles in coordinating postnatal hair growth by interacting with both epithelial and mesenchymal compartments.
1 citations
,
September 2015 in “Elsevier eBooks” This review discusses the role of Sox2 in skin development, hair follicle regeneration, cancer, and wound healing, and reports no new experimental results.
January 2022 in “Stem cell biology and regenerative medicine” This review explores the role of lymphatic vessels in skin regeneration and hair follicle growth, emphasizing their interactions with hair follicle stem cells and potential implications for regenerative therapies, but reports no new clinical results.
December 2021 in “Morphologia” This article reviews the characteristics and therapeutic potential of neural crest cells from various sources, including embryonic and mature stem cells, but reports no new experimental results.
333 citations
,
February 2010 in “Cell Stem Cell” This review discusses experimental data, technologies, and genetic factors related to stem cell niches, highlighting their role in tissue regeneration and diseases, but reports no new results.
330 citations
,
December 2009 in “Cell stem cell” This study suggests that skin-derived precursors from Sox2(+) hair follicle dermal cells have the potential to function as dermal stem cells, supporting hair morphogenesis, dermal maintenance, and wound-healing.
May 2023 in “Stem cell research & therapy” This study describes a novel method using force-triggered density gradient sedimentation for efficiently isolating dermal papilla cells from neonatal mouse skin, showing promise for hair follicle regeneration research.
551 citations
,
November 2013 in “Nature” This study found that differentiated airway epithelial cells can revert into functional stem cells in vivo, suggesting a more general role for this dedifferentiation process in tissue regeneration in higher vertebrates.
13 citations
,
July 2014 in “Cell stem cell” This study identified a novel phase of stem cell quiescence, GAlert, in mice, regulated by mTORC1, that primes stem cells for injury response.
75 citations
,
September 2017 in “Developmental biology” This review discusses circadian clock regulation in stem cells and its role in processes like neurogenesis, but reports no new results; the authors emphasize its significance in stem cell function across various tissues.
42 citations
,
January 2017 in “Stem cells international” This study found that while extracellular matrix components like hyaluronic acid promoted larger organoid formation, other matrix components hindered hair follicle germ assembly in an in vitro model.
153 citations
,
October 2007 in “Cell Stem Cell” New research suggests that skin cell renewal may not require a special type of cell previously thought to be essential.
561 citations
,
April 2003 in “Journal of Investigative Dermatology” CD34 is a marker for isolating stem-like cells in mouse hair follicles.
92 citations
,
March 2016 in “Developmental Cell” Zebrafish skin regeneration relies on cell behaviors and reactive oxygen species, with antioxidants reducing and hydrogen peroxide increasing regeneration.
2 citations
,
May 2021 in “Bioengineering” This article reviews the evolving understanding of hematopoietic stem cells, including their heterogeneity and the role of cytokines in lineage determination, and reports no new results.