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The April 2016 JEADV issue covered various dermatology topics, including psoriasis, psoriatic arthritis, mTOR inhibitors, autoimmune diseases, photodynamic therapy, viral DNA in skin diseases, chronic hand eczema, and female hair loss.

Genetic defects and UV radiation cause skin damage and aging.

The document explains how certain drugs block hormones to treat cancers like breast and prostate cancer.

Men and women experience skin aging differently due to changes in sex hormone levels with age.

Isotretinoin and tazarotene help treat acne, while minoxidil and finasteride promote hair growth.

The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.

Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.

Pygmy goats with seborrhoeic dermatitis showed skin symptoms and temporary improvement with corticosteroids, but the cause and inheritance of the disease remain unknown.

Small proline-rich proteins and trichohyalin help make epithelial tissues tougher and more flexible.

Isotretinoin shrinks sebaceous glands without affecting hair or skin color, unlike etretinate.

Ethosomes are effective, safe carriers for delivering drugs through the skin.

JAK inhibitors may become the first approved treatment for alopecia areata if they are proven safe and effective.

Low oxygen areas help maintain and protect blood stem cells by using a simple sugar breakdown process for energy and managing their activity levels.

DGAT1 enzyme helps make diacylglycerols, waxes, and retinyl esters.

A new, quick method was developed to analyze skin lipids, discovering a new ceramide subclass.

Free fatty acids in sebum boost skin's defense against acne by increasing antimicrobial peptides.

The absence of functional sebaceous glands causes hair follicle destruction and scarring alopecia.

Involucrin gene expression is controlled by specific proteins and signaling pathways.

The new matrix improves skin regeneration and graft performance.

Scalp itching is common and hard to diagnose due to the complex nerve structure of the scalp.

TGFβ signaling prevents sebaceous gland cells from producing fats.

Cidea is essential for proper lipid storage and secretion in sebaceous glands, affecting skin and hair health.

ACBP is crucial for healthy skin in mice.

18-MEA and cationic surfactants can restore and maintain hair's hydrophobic nature, improving its beauty and feel.

Nitroxide drugs can safely and effectively treat age-related diseases like macular degeneration and cardiovascular issues.

PTEN helps control the number and health of skin stem cells by working with the protein BMAL1.

RNA delivery is best for in-body use, while RNP delivery is good for outside-body use. Both methods are expected to greatly impact future treatments.

Mutations in NIPAL4 cause skin issues by disrupting lipid layers, but some improvement is seen with topical treatment.

Acne can't be cured but can be managed with treatments like benzoyl peroxide and diet changes; it's costly and can lead to scarring and mental health issues.

New treatments like nanotechnology show promise in improving skin cancer therapy.