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This review explores various substances with potential antiandrogenic effects for treating acne, highlighting evidence for isotretinoin, and discusses the future consideration of 5 alpha-reductase inhibitors as antiandrogens.

This study found that diphlorethohydroxycarmalol significantly increased prostaglandin $E_2$ synthesis in HaCaT human keratinocytes by upregulating COX-1 and COX-2 expression, suggesting potential benefits from elevated $PGE_2$ production.

This study found that conditioned medium from hair dermal papilla cells stimulated fetal bovine aortic endothelial cell growth and migration, suggesting VEGF-like activity in the medium.

This study found that the natural extract e-CAF promotes the proliferation and migration of human hair dermal papilla cells in vitro, suggesting potential benefits for skin regeneration and tissue repair.

This study found that the 5α-steroid metabolite profile in men with inherited 5α-reductase deficiency is similar to those taking the drug finasteride, suggesting the gene affects multiple steroid substrates.

This study observed that antisense oligonucleotides targeting FGFR-1 increased cellular activity in hair follicle cultures from mice, suggesting potential clinical utility for treating baldness.

In this study, researchers found that finasteride inhibits progesterone synthesis by blocking cholesterol side-chain cleavage in mouse-derived MA-10 Leydig cells, but this effect may not be evident in human or rat cells.

This study found that minoxidil and ranolazine, individually and in combination, reduced cellular invasiveness in hypoxic triple-negative breast cancer cell lines, suggesting potential anti-metastatic effects at clinically relevant doses.

This study found that Ishige sinicola extract stimulated osteoblast differentiation and bone formation in MC3T3-E1 cells, suggesting potential use for osteoporosis prevention and treatment.

In this study using mice, fractional CO2 laser therapy promoted hair regrowth by inducing moderate inflammation, enhancing VEGF-mediated angiogenesis, and activating the Wnt10b signaling pathway.

This study found that compound 3 derived from aza-bicyclo-carboxylic acid may exert a cardioprotective effect by reducing infarction area in myocardial ischemia-reperfusion injury, potentially involving A1-adenosine receptor activation and changes in cAMP levels.

In this study, finasteride inhibited progesterone synthesis in mouse-derived MA-10 Leydig tumor cells by blocking cholesterol side-chain cleavage, but human and rat cells showed minimal sensitivity.

This study found that 2-ethylhexanoic acid impaired fertility in Wistar rats and delayed postnatal development of pups, suggesting potential reproductive toxicity at certain dosages.

This review discusses the role of histone deacetylases in hearing loss, proposing potential pharmacological interventions, but reports no new clinical results.

This study found that methanolic extract of Ficus carica leaves induced apoptosis and inhibited proliferation in B16F10 melanoma cells, suggesting potential anti-cancer properties for further investigation in melanoma.

This study found that platycodon ethanol extract showed potential as a natural ingredient for hair loss prevention by increasing radical scavenging ability, inhibiting inflammation, and affecting DHT generation in laboratory experiments.

This study found that a topical plant worm extract significantly accelerated hair regrowth in mice without apparent toxicity or side effects.

This review highlights the broad range of adverse effects associated with isotretinoin in acne treatment and examines strategies such as dietary supplementation and adjusted dosing protocols to enhance patient tolerability while maintaining efficacy.

In this study, DOP treatment improved hair regrowth in androgenetic alopecia by altering local steroid metabolism and follicular morphology.

This study found that a mesenchymal stromal cell-derived regenerative extracellular matrix (rECM) significantly accelerated wound closure and improved healing in diabetic mice, also enhancing nerve and blood vessel formation compared to controls.

This study established a murine model for radiation-induced skin reactions, replicating clinical and histological features to aid future mechanistic and therapeutic research.

This review synthesizes information on isotretinoin’s systemic toxicity, emphasizing that its adverse effects, including mucocutaneous, hepatic, and musculoskeletal reactions, primarily reflect its pharmacodynamic actions and are generally manageable with individualized dosing and monitoring, though its teratogenicity remains a significant safety concern.

This study found that platelet-rich plasma might support brain health by enhancing glial cell function and modulating immune responses in inflammation, indicating potential as a treatment for brain disorders.

This research found that kaempferol, a flavonoid from hair growth-promoting plants, significantly enhanced human dermal papilla cell proliferation and inhibited specific signaling pathways, outperforming minoxidil, with topical application in mice promoting hair growth and thickness, indicating potential as a natural hair loss treatment.

This study found that in vitro environments simulating testosterone levels in elderly males, testosterone and its metabolite DHT significantly reduced macrophages' ability to phagocytize MRSA and Pseudomonas aeruginosa, suggesting AR manipulation and inhibiting testosterone-DHT conversion might help fight wound infections in the elderly.

This review highlights that bicalutamide, a non-steroidal antiandrogen used in prostate cancer treatment, is mainly effective through its (R)-enantiomer and emphasizes the need to monitor its adverse effects despite its targeted antiandrogenic action.

BrdU speeds up hair follicle aging and reduces hair quality.

In this study, researchers evaluated CS12192, a selective JAK3 inhibitor, in an alopecia areata mouse model and found it reversed hair growth inhibition comparably to baricitinib, with better safety and similar immune-modulating mechanisms.

This study reports that in mesenchymal cells, the effect of resveratrol on cell viability and metabolic enzyme activity varied with dosage and exposure time, with high doses promoting bone differentiation and potentially benefiting mesenchymal cell health and differentiation into osteoblasts.

This review discusses the common occurrence of docetaxel-induced hair loss in cancer patients, including permanent cases, and highlights current and experimental strategies like scalp cooling, minoxidil, and new clinical trials for managing and preventing this side effect.