January 2022 in “International Journal of Medical Sciences” This study investigated the effects of cedrol on colorectal cancer and found that it inhibited cell proliferation and induced cell cycle arrest and apoptosis in cell models, while in vivo, it suppressed cancer progression and improved survival at a well-tolerated dose.
May 2024 in “IntechOpen eBooks” In this study, the authors explored the efficacy of hyperbaric oxygen therapy for typical sports injuries and cosmetic surgical wounds, finding that a hormetic dose-response relationship could explain the observed successes, contrary to prevailing expert opinion that deemed this treatment ineffective for normal wounds.
1 citations
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June 2021 in “General physiology and biophysics” In this study, minoxidil-induced vasodilation in rat aorta was found to be mediated by ATP-sensitive potassium channels and nitric oxide pathways, but was not significantly altered by lipid emulsion pretreatment.
6 citations
,
August 1989 in “European journal of pediatrics” This case study describes a child with rickets and alopecia who responded to a small dose of 1-a-hydroxyvitamin D3, but her alopecia remained unchanged despite treatment.
24 citations
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August 2020 in “JAMA dermatology” In this study, researchers observed a dose-dependent occurrence of persistent radiation-induced alopecia in patients with primary CNS tumors or head and neck sarcomas, noting distinctive patterns and features, and suggesting potential benefits of topical minoxidil and procedural interventions for treatment.
19 citations
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June 1999 in “Steroids” This study found that compound 10 inhibited testosterone conversion to DHT in hamster flank organs and seminal vesicles, whereas compound 11's inhibitory effect varied with dose, linked to halogen electronegativity differences.
116 citations
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April 2002 in “American journal of veterinary research” This study found trilostane to be an effective and generally safe treatment for improving symptoms in dogs with pituitary-dependent hyperadrenocorticism.
83 citations
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October 2012 in “International Journal of Oncology” In this in vitro study, wedelolactone induced selective apoptosis in prostate cancer cells by inhibiting 5-Lox activity, suggesting it may have potential as a treatment for prostate cancer.
August 2025 in “Therapeutics” In this study, low concentrations of DMSO were found to decrease androgen receptor expression and inhibit the migration of prostate cancer cells, suggesting potential as an anticancer therapy.
March 2025 in “Scientific Reports” This study found a complex relationship between cumulative doses of 5-ARIs and all-cause mortality among BPH or AGA patients, with lower doses linked to higher suicide rates and higher doses reducing cardiovascular mortality risk.
January 2023 in “Skin appendage disorders” This review discusses the potential of low-dose oral minoxidil as a safe and effective treatment for certain hair disorders, including alopecia, but reports no new clinical results.
6 citations
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July 2016 in “Doklady Biochemistry and Biophysics” This study found that GD-23, a dipeptide ligand of TSPO, exhibited an anxiolytic effect in the elevated plus maze test, which was inhibited by selective neurosteroid synthesis inhibitors, suggesting a neurosteroidogenic mechanism.
October 2024 in “Journal of the Endocrine Society” This study highlights a rare case of vitamin D-dependent rickets type 2A caused by a heterozygous mutation in the vitamin D receptor gene, emphasizing the complexity of managing this condition with high-dose calcium and vitamin D therapy.
July 2023 in “Journal of medical and health studies” This case study reported on a 3-year-old child with vitamin D-dependent rickets type II treated in the Gaza Strip, whose condition deteriorated despite vitamin D and calcium treatments, leading to recurrent chest infections, respiratory failure, and eventual death.
June 2016 in “Journal of Coastal Life Medicine” This case report describes a 10-year-old terrier with pituitary-dependent hyperadrenocorticism successfully treated with mitotane.
January 2023 in “International Journal of Contemporary Pediatrics” This case study describes a 5-year-old boy with vitamin D dependent rickets type 2, motor delays, and alopecia totalis who showed improved biochemical parameters with calcium and calcitriol treatment.
March 2009 in “The Journal of Urology” Low dose finasteride causes only minor changes in PSA levels in men over 50 with BPH.
42 citations
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January 2002 in “Skin Pharmacology and Physiology” This study reported that reconstructed skin models can be useful for studying the effects of non-water-soluble topical products on xenobiotic metabolism, particularly in enzyme activities like EROD and GST.
April 2026 in “Biomedical Materials” In this study, gold nanoparticle-conjugated curcumin and thymoquinone formulations were more effective against melanoma cells in 3D bioprinted scaffolds than free or co-administered phytochemicals, sustaining stress responses and overcoming tumor adaptation barriers.
29 citations
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July 2012 in “Fertility and Sterility” This study observed that hepatotoxicity is a rare but possible event in hyperandrogenic young females treated with low- and ultralow-dose flutamide, regardless of dose or oral contraceptive use.
7 citations
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April 2023 in “Frontiers in Surgery” This study found that a single dose of 1 mg/kg dexamethasone promoted wound healing in septic mice but delayed it in normal mice.
118 citations
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May 2003 in “Toxicological Sciences” This study found that prenatal exposure to finasteride in rats led to permanent changes in developmental endpoints like anogenital distance and nipple retention, which were predictive of further reproductive tract malformations.
40 citations
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January 1994 in “Skin Pharmacology and Physiology” This study found that testosterone and 5α-dihydrotestosterone affect human sebocytes differently depending on the skin region, with spironolactone inhibiting their proliferation and counteracting androgen effects in facial sebocytes.
44 citations
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May 1998 in “PubMed” In this study, a specific retinoic acid receptor antagonist caused severe craniofacial anomalies in mouse fetuses when administered early in pregnancy, but not limb anomalies, highlighting developmental stage-specific roles of retinoic acid.
57 citations
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June 2003 in “American Journal of Physiology-cell Physiology” This study found that cyclosporin A treatment enhances hair growth in mice by inhibiting calcineurin-NFAT1 activity, which alters keratinocyte differentiation and apoptosis-related gene expression in hair follicles.
23 citations
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November 2015 in “Phytotherapy Research” This study found that cucurbitacin I from bitter melon most effectively inhibited the growth of lung cancer cells and promoted hair cell growth in cell cultures.
5 citations
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September 2017 in “Plastic and Aesthetic Research” This study aimed to assess whether using minoxidil alongside nutritional cyclical supplements could boost hair regrowth without antiandrogens or enzyme blockers, focusing on hair root strengthening. Results are not reported.
July 2023 in “Research Square (Research Square)” In this study conducted on rabbits, conventional blood treated with 120% sodium citrate was observed to achieve the highest platelet recovery and enrichment coefficient, while altering sodium citrate concentrate affected levels of growth factors PDGF and TGF-β1 after plasma activation.
49 citations
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July 2008 in “Alcoholism Clinical and Experimental Research” This study found that finasteride dose-dependently blocked the acquisition of ethanol drinking in mice and maintained reduced consumption even after treatment ended.
17 citations
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January 2021 in “Agrobiological Records” This study reported that allethrin caused dose-dependent toxico-pathological effects, including decreased feed intake, body weight, and blood parameters, and organ damage in adult male albino rats.