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In this study, a Chinese Han family with hereditary vitamin D-resistant rickets was found to have a homozygous missense mutation in the VDR gene, and the affected individual uniquely responded well to treatment with oral calcium and low-dose calcitriol.

This case report highlights an atypical presentation of acrodermatitis enteropathica in an 18-year-old male, exhibiting symptoms like erythrokeratoderma variabilis with a positive response to high-dose oral zinc, underscoring the importance of considering zinc deficiency in unusual skin conditions.

This study found that glycyrrhizic acid significantly reduced stem cell characteristics of dermal papilla cells by down-regulating key signaling pathways, suggesting potential use in suppressing unwanted hair growth.

This study observed early cardiac effects in young minipigs following high-dose doxorubicin chemotherapy, with a decrease in heart function and changes in cardiac MRI measurements compared to controls.

This study found that prenatal exposure to finasteride in pregnant rats significantly disrupted male reproductive development, confirming its use as a positive control for androgen-related reproductive effects.

This study found that emodin from Polygonum multiflorum showed 5alpha-reductase inhibitory activity, which was more potent than alizarin but less potent than riboflavin.

This study found that p2y5 functions as a novel LPA receptor involved in the G13-Rho signaling pathway, with implications for human hair growth, and proposes renaming it to LPA6.

This study found that the immune-competent B6. Cg‐Tyr c−2J Hr hr /J congenic mouse line had a more pronounced delayed sunburn response and different proliferative skin reactions to UV exposure compared to SKH 1 mice.

This study found that metyrapone and etomidate provide dose-dependent anticonvulsant effects against seizures, with delayed effectiveness linked to increased neurosteroid levels.

This review discusses the complexities of hidradenitis suppurativa pathogenesis, highlighting issues with Notch signaling, immune dysregulation, and the role of keratinocytes and ECM, but reports no new clinical results.

This study found that the Qing Cuo Formula significantly reduced serum androgen and inflammatory cytokine levels in hamsters with damp-heat acne and identified potential molecular mechanisms and active compounds involved.

This study developed and tested Bicalutamide-loaded lipid vesicles in dissolving microarray patches for topical application, finding that they effectively deliver Bicalutamide through murine skin while maintaining a favorable safety profile, suggesting potential to improve treatments for androgenetic alopecia.

This study found that metformin is inversely associated with serum PSA levels in a dose-dependent manner, suggesting further research is needed on its potential impact on prostate cancer progression.

In this study, pregnenolone was found to dose-dependently reduce L-DOPA-induced dyskinesias in a rat model of Parkinson's disease, suggesting its potential as a therapeutic target for these dyskinesias.

This study reports that combining baricitinib with low-dose cyclosporine and steroids resulted in effective and safe treatment for a case of alopecia totalis, maintaining hair regrowth without adverse effects.

The authors concluded that the dermal response to epidermal Wnt/β-catenin signaling depends on distinct fibroblast lineages, with each responding to different paracrine signals such as Hedgehog and TGF-β.

This study found that the 1 mg dose of finasteride was associated with a wide range of adverse effects, including sexual, psychological, and metabolic symptoms, in the FAERS data.

This review found that oral minoxidil, used for treating androgenetic alopecia, can cause dose-dependent fluid retention and weight gain, but remains safe for most patients; a diuretic might be needed if significant weight gain occurs.

This study suggests that vitamin A may inhibit hair follicle stem cells during refractory telogen in a dose-dependent manner, based on retinyl ester levels and vitamin A metabolism protein localization in mice.

The new chemotherapy combination for advanced lung cancer showed a 35.7% response rate but caused significant side effects.

This study observed that in spontaneously hypertensive rats, testosterone's effects on endothelium-dependent vasodilation involved reduced nitric oxide levels, increased oxidative stress, and greater reliance on endothelium-dependent hyperpolarization, with variations in these responses noted when testosterone was combined with either anastrozole or finasteride.

This study found that recombinant human leukocyte interferon alfa-2a achieved a 64% overall antitumor response rate in patients with early and advanced cutaneous T cell lymphoma and was generally well-tolerated.

In this case report, a 14-year-old girl with nephrotic syndrome developed large edematous striae distensae due to high-dose steroid use and rapid body size increase from edema fluid accumulation.

In this study, patients with varying severities of acne, seborrhoea, and hirsutism responded differently to Cyproteronacetate and Ethinyloestradiol treatment, with improvement rates dependent on symptom severity and treatment duration.

This study identified hair shaft progenitors in the matrix that regulate hair growth and pigmentation by creating a niche dependent on stem cell factor, implicating KROX20+ cells in these processes.

This review examines the role of androgens in cutaneous disorders and the potential therapeutic effects of different oral contraceptives, noting variations in individual responses and the influence of genetic and local factors but reports no new clinical results.

In this study, combination therapy with cyclosporine and PUVA for severe alopecia areata resulted in a majority of patients showing only fair to poor responses, though some improvements were noted.

This study found that the application of plant-derived biostimulants, Trainer® and Auxym®, significantly affected various physiological traits in lettuce, but responses varied depending on the cultivar.

In this study, ozenoxacin was found to inhibit sebum production in insulin- and 5α-DHT-differentiated hamster sebocytes in a dose-dependent manner, suggesting potential benefits in acne management by combining antimicrobial activity against C. acnes with reduced sebum production.

This systematic review found that hair loss was more frequently observed in acne patients on isotretinoin doses ≥0.5 mg/kg/d compared to those on lower doses, suggesting dose-dependent effects.