November 2019 in “Neuro-oncology” This study found that using rind-based dosimetric techniques in brain irradiation significantly reduced scalp dose and alopecia compared to standard treatment plans, with 60% of patients experiencing no hair loss.
2 citations
,
April 2024 in “Urology Annals” Taking dutasteride every other day works as well as daily and better preserves sexual function.
16 citations
,
March 2006 in “The American journal of psychiatry” This report describes five cases where sudden akathisia occurred in female patients with bipolar disorder after a ziprasidone dose reduction, emphasizing potential unexpected side effects of second-generation antipsychotics.
70 citations
,
February 2018 in “Seminars in Arthritis and Rheumatism” This study found that belimumab helped achieve low disease activity in over 40% of systemic lupus erythematosus patients in real-life settings, alongside reduced corticosteroid use and fewer flares.
62 citations
,
December 1995 in “The Journal of Clinical Endocrinology & Metabolism” This study found that combining a GnRH agonist with a low-dose oral contraceptive was more effective in treating hirsutism than either agent alone and prevented hypoestrogenic side effects.
14 citations
,
January 2013 in “Journal of Cutaneous Medicine and Surgery” This study describes permanent scalp alopecia in patients receiving chemotherapy, radiation, or both, and highlights the need for further research to identify causative factors and mitigation strategies.
13 citations
,
November 2013 in “Seizure: European Journal of Epilepsy” This study reports that hair loss may be a rare side effect of levetiracetam in epilepsy patients and appears reversible upon dose reduction or cessation.
2 citations
,
October 2018 in “Springer eBooks” Cancer treatments can cause skin-related side effects that may affect patient quality of life and require changes in treatment.
2 citations
,
August 2016 in “Lasers in Surgery and Medicine” In this study, photodynamic therapy was found to achieve permanent reduction of nonpigmented hair in mice, unlike an 800-nm diode laser, by targeting the hair matrix through repeated sessions.
August 2022 in “Journal of The American Academy of Dermatology” This study observed a slight reduction in blood pressure in normotensive patients after taking a 5-mg dose of oral minoxidil, particularly within the first two hours and more so in those with high baseline blood pressure.
9 citations
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January 2015 in “Indian Journal of Pharmacology/The Indian journal of pharmacology” This study reports that alopecia may develop in patients with chronic exposure to high plasma concentrations of valproate, but resolved after dose reduction or treatment discontinuation.
27 citations
,
January 2001 in “Hormone Research in Paediatrics” This study found that a lower maintenance dose of flutamide (125 mg/day) effectively maintained the reduction in hirsutism achieved with an initial higher dose (250 mg/day) in women, without additional side effects.
March 2025 in “International Journal of Scientific Research” This study found that low-dose oral minoxidil effectively increased hair count over 24 weeks with mild reductions in blood pressure and minimal adverse effects among participants, suggesting its potential as a safe treatment for hair loss.
1 citations
,
January 1994 in “Drug Development and Industrial Pharmacy” This study suggests that certain combinations of topical radioprotectors and vehicles can reduce radiation-induced hair loss in mice, with effectiveness varying by radiation dose and vehicle type.
59 citations
,
February 2021 in “BMJ” This study found a strong dose-related increase in the risk of intracranial meningiomas associated with high doses of cyproterone acetate, with some reduction in risk after stopping the treatment.
June 2019 in “Poster presentations” This study found that low dose methotrexate did not increase hair loss in rheumatoid arthritis patients compared to healthy controls, and many patients even showed a reduction in hair fall over the short term.
5 citations
,
January 2021 in “Daru” This case report highlights a rare instance of severe multi-organ involvement following a single dose of methotrexate for ectopic pregnancy, requiring intensive care but ultimately successfully treated with leucovorin and supportive care.
In this study, long-term low-dose finasteride use in men with alopecia was associated with a significant reduction in the diagnosis of benign prostatic hyperplasia and prostate cancer, although further research is needed to understand the mechanisms and long-term effects.
March 2017 in “DOAJ (DOAJ: Directory of Open Access Journals)” This study suggests that using vitamin A, vitamin E, and vitamin C for two months may enable a reduction in corticosteroid dosage for alopecia areata, potentially mitigating associated side effects.
1057 citations
,
November 2011 in “Annals of Biomedical Engineering” This review discusses the applications of low level laser therapy (LLLT) in wound healing, pain reduction, and treating various conditions, but reports no new clinical results; the authors highlight the need for randomized controlled trials for serious diseases.
1 citations
,
January 2026 in “International Journal of Dermatology” In this study, a case of dissecting cellulitis of the scalp was reported in a man after starting dupilumab therapy, highlighting potential immune pathways involved and the importance of recognizing such paradoxical inflammatory reactions to prevent irreversible alopecia.
2 citations
,
January 2023 in “Curēus” In this study, low-dose naltrexone significantly reduced erythema in patients with frontal fibrosing alopecia and lichen planopilaris after one year, but no significant improvements were seen in other symptoms.
February 2018 in “Zenodo (CERN European Organization for Nuclear Research)” This study observed that administering 1000 mg/kg of LSFP significantly reduced serum FSH and LH levels and testicular index in male Wistar rats, while lower doses showed no such effect.
3 citations
,
December 2019 in “Lupus” In this report, researchers describe a case of scalp discoid lupus erythematosus unresponsive to topical treatments, where hydroxychloroquine administered at 200 mg/day led to complete resolution of skin lesions in five months.
July 2026 in “Journal of Medical Imaging and Radiation Oncology” This study reviewed evidence on cutaneous reactions and associated radiation doses from cranial or spinal neurointerventional procedures, finding that alopecia/epilation was most common and onset doses often aligned with known thresholds, highlighting the need for standardized dose reporting and follow-up.
April 2023 in “Journal of Investigative Dermatology” This study reviewed data from three hospitals and found that alopecia after DRESS occurred more often in severe cases, but the rate of corticosteroid treatment did not significantly differ between patients with and without alopecia.
March 2025 in “Journal of Clinical Medicine” This study reviewed adverse events associated with low-dose oral minoxidil for treating alopecia, finding hypertrichosis and fluid retention as common, typically manageable side effects without needing treatment discontinuation.
51 citations
,
October 2002 in “European journal of endocrinology” This study found that both high-dose and low-dose finasteride significantly reduced hirsutism scores in women after 12 months, with the lower dose being safe and cost-effective.
22 citations
,
September 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” This review highlights the possible role of T regulatory cells in the immune-related mechanisms of alopecia areata but reports no new clinical findings.
18 citations
,
January 2003 in “Gynecological Endocrinology” In this study, low-dose finasteride (2.5 mg/day) significantly reduced hirsutism scores in women over 12 months without significant hormonal changes or serious side effects.