November 2025 in “PLoS ONE” This study observed that albino rats, despite not producing melanin, have melanocytes localized in specific skin areas of their hair matrix, suggesting that gene expression analysis of their skin should consider regional differences in melanocyte presence.
October 2025 in “Advanced Healthcare Materials” In a study on wound healing, researchers described injectable POEGMA‐DA hydrogels as a promising non-toxic alternative to traditional wound closure methods, showing effective tissue adhesion and enhanced regeneration of skin structures in a mouse model without significant inflammation.
In this review, researchers analyzed literature on trichotillomania and found advances in understanding its neurobiology—highlighting dysregulated reward circuits and genetics—and treatments, with behavioral therapy and innovative pharmacological approaches improving outcomes where traditional SSRIs do not.
This review highlights advances in understanding trichotillomania's neurobiology and treatment, noting behavior therapy's effectiveness and new pharmacological and digital therapies, while addressing underdiagnosis, stigma, and research gaps.
In this literature review, researchers highlighted that trichotillomania involves dysregulated reward circuits, abnormal sensory processing, and potential genetic factors, advancing both therapeutic strategies and understanding of the condition, but stigma and provider training gaps persist in effective care provision.
In this study, female patients with Female Pattern Hair Loss were found to have significantly lower serum levels of vitamin D and ferritin, as well as lower total cholesterol and triglyceride levels, compared to healthy controls, suggesting these factors may contribute to the condition's pathogenesis.
March 2025 in “Frontiers in Pharmacology” This study developed a hydrogel dressing incorporating angelica polysaccharides, demonstrating enhanced wound healing properties in a mouse model by promoting rapid hemostasis, tissue healing, and new blood vessel formation compared to Tegaderm™ film.
February 2025 in “Brazilian Journal of Hair Health” This case study found that multiparametric ultrasound can be an effective non-invasive diagnostic tool for evaluating scalp changes in alopecia areata following repeated corticosteroid injections, potentially offering an alternative to biopsy.
February 2025 in “Biomimetics” This study developed a novel hair-straightening shampoo incorporating a polyphenol–inorganic sulfate redox agent, finding that it effectively straightens hair while enhancing strength and reducing damage due to its protective polyphenol coating.
September 2024 in “Frontiers in Neuroendocrinology” In this review, the researchers reported that 5α-reductase inhibitors demonstrated neuroprotective effects and reduced dyskinesias in animal models of Parkinson's disease, suggesting their potential for repurposing to manage symptoms in men with PD.
September 2024 in “Journal of Investigative Dermatology” VIP reduces hair pigmentation by decreasing melanin production.
May 2024 in “Journal of colloid and interface science” This study developed a bilayer bionic skin scaffold that mimics the skin's structure to resist microbial invasion and enhance wound healing, with in vivo animal studies showing improved collagen deposition, neovascularization, and hair follicle formation.
May 2024 in “Nano letters” This study developed a quercetin-encapsulated and polydopamine-integrated nanosystem that reshapes the perifollicular microenvironment, showing potential for rescuing hair follicle viability and regenerating hair follicles in androgenic alopecia by scavenging reactive oxygen species and promoting angiogenesis.
March 2024 in “Journal of Applied and Natural Science” This study found that administering an alcoholic extract of Mentha spicata leaves significantly reduced testosterone levels and aggressive behavior in female rats with elevated testosterone, suggesting its potential protective role against such symptoms.
This study found that activation of delta-opioid receptors in keratinocytes may delay the expression of the PER2 gene, suggesting a possible link to cancer development through circadian rhythm disruption.
November 2023 in “International journal of biology, pharmacy and allied sciences” This review highlights scientific information about the medicinal uses and phytochemistry of Musa paradisiaca plant parts, which are traditionally used in human medicine to treat conditions such as diabetes, diarrhoea, hypertension, and ulcers, and exhibit various pharmacological activities including antidiabetic, antioxidant, and wound healing effects.
August 2023 in “International Journal of Molecular Sciences” This study observed unexpected heterogeneity among pigment cells in human scalp hair follicles, identifying immature melanocyte populations outside traditional pigment production zones, raising questions about their potential roles beyond melanin synthesis.
May 2023 in “Cytotherapy” This study found that medium/large extracellular vesicles derived from hair follicle and adipose tissue mesenchymal stromal cells both demonstrated significant neuroprotective and anti-inflammatory effects in cell cultures, highlighting their potential use as biopharmaceuticals for treating neurodegenerative diseases.
This study found that Polygonum multiflorum radix ethanol extract may promote melanin synthesis, potentially helping to turn gray hair back to black by enhancing antioxidant activity and increasing tyrosinase expression.
This study found that neonatal administration of Allopregnanolone may mitigate some behavioral effects of early maternal separation in adolescence, but also lead to similar adverse effects as the separation in adulthood.
January 2017 in “Corpus Université Laval (Université Laval)” This study found that dutasteride may offer neuroprotective effects on dopaminergic neurons in an animal model of early-stage Parkinson's disease, suggesting potential therapeutic use.
January 2009 in “Side effects of drugs annual” This study observed no teratogenic effects of oral decongestants and surprisingly favorable neonatal outcomes in Swedish women who used them during pregnancy.
December 2006 in “Annales D Endocrinologie” This article reviews clinical and treatment aspects of hyperandrogenism in women, emphasizing the roles of diagnostic practices, combined oral contraceptives, and cyproterone acetate, but introduces no new findings.
June 2006 in “Basrah journal of surgery” This study observed that adding Metformin to Clomiphene Citrate in treating obese, hirsute women with PCOS improved ovulation induction, but its benefits for all women with PCOS remain uncertain.
November 2003 in “Journal of Neurochemistry” This study suggests that the neurosteroid allopregnanolone may play a crucial role in how ethanol affects neurons related to alcohol addiction vulnerability.
October 2022 in “Biomolecules” This study found that in male rats, chronic finasteride treatment reduced allopregnanolone levels, which, upon drug withdrawal, correlated with increased pro-inflammatory cytokines and altered neurotransmitter levels.
May 2022 in “Endocrine Abstracts” Finasteride may cause sexual dysfunction by reducing epinephrine levels.
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November 2013 in “Urologia Internationalis” This study reviews the significant prevalence of organic etiologies, especially vascular causes, in erectile dysfunction among men under 40 and emphasizes thorough evaluation and consideration of treatment options like exercise and PDE-5 inhibitors.
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November 1987 in “British Journal of Dermatology” This study observed increases in scalp blood flow following the application of 3% minoxidil and 0.1% hexyl nicotinate in individuals with alopecia.
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August 2019 in “Frontiers in Immunology” This review examines non-invasive methods for diagnosing inflammatory skin diseases like lupus erythematosus and psoriatic inflammation using samples from plucked hair and skin tape-strips, but no new clinical results are presented.