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Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

5α-reductase inhibitors can cause sexual problems, higher risk of aggressive prostate cancer, and depression.

5α-reductase inhibitors can cause serious and possibly lasting sexual and psychological side effects.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Targeting androgen receptors could be a promising way to treat skin disorders with fewer side effects.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Finasteride helps reduce heart issues and improves heart function.

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

New methods to make oxasteroids show promise for medical treatments like osteoporosis and breast cancer.

5-alpha reductase deficiency leads to male sexual development issues and treatments like finasteride help with prostate enlargement and hair loss.

Finasteride treatment changes brain steroid levels and receptors, affecting brain function even after stopping treatment.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Lack or blocking of SRD5a, a key component in hormone creation, can lead to conditions like pseudohermaphrodism and affect hair growth, bone mass, muscle strength, and reproductive health. More research is needed on its regulation from fertilization to adulthood.

Long-term use of dutasteride for enlarged prostate may worsen blood sugar, cholesterol, and erectile dysfunction.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

Natural herbal compounds might treat certain medical conditions by reducing DHT levels, but more research is needed to confirm their effectiveness and safety.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

5α-reductase inhibitors don't stop bladder cancer from developing or getting worse.

Vitexin Compound 1 may help reduce skin aging caused by UVA light.

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

TRPV3 could be a target for treating pain, skin disorders, and hair problems, but more research is needed to create effective drugs.

We need to learn more about 5α-reductases and neuroactive steroids to safely make drugs targeting these enzymes.

5α-reductase inhibitors help shrink the prostate, improve urinary symptoms, and may reduce prostate cancer risk.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Muscles can make their own androgens, which may help muscle growth.

Long-term use of finasteride and dutasteride can cause serious health issues like diabetes and liver problems.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.