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research Finasteride Inhibits the Disease-Modifying Activity of Progesterone in the Hippocampus Kindling Model of Epileptogenesis
Finasteride worsens seizures in epilepsy rats and speeds up epileptogenesis in mice.
research Differential Effects of Propranolol on Heart Rate and Plasma Renin Activity in Patients Treated with Minoxidil
Propranolol affects heart rate and renin levels in minoxidil-treated patients.
research Age Dependence of the Cardiac Lesions Induced by Minoxidil in Rats
Older rats more affected by minoxidil's cardiotoxic effects than younger rats.
research Radioimmunoassay of Minoxidil in Human Serum
Minoxidil levels measured in human blood.
research Androgenic and Anti-Androgenic Effects of Progesterone Derivatives with Different Halogens as Substituents at the C-6 Position
Different halogens on progesterone derivatives can either block or mimic male hormone effects, depending on their type and amount.
research Rapid Blood Pressure Control With Minoxidil
Minoxidil effectively lowers blood pressure and initially increases plasma renin activity without raising aldosterone levels.
research FCE 28260, A New 5α-Reductase Inhibitor: In Vitro and In Vivo Effects
FCE 28260 is a stronger and longer-lasting inhibitor of 5α-reductase than finasteride, which may make it a better treatment for certain medical conditions.
research Cardiovascular Toxicity of Minoxidil in the Marmoset
High doses of minoxidil can harm marmoset hearts and kidneys, possibly affecting humans similarly.
research Rat Steroid 5α-Reductase Kinetic Characteristics: Extreme pH-Dependency of the Type II Isozyme in Prostate and Epididymis Homogenates
The activity of a specific rat enzyme in the prostate and epididymis is highly dependent on the acidity level.
research Recent Advances in Drug Design and Drug Discovery for Androgen-Dependent Diseases
New treatments for prostate cancer and BPH show promise, including novel compounds that target hormone synthesis and response.
research Androgens and Erythropoiesis: Induction of Erythropoietin-Hypersecretory State and Effect of Finasteride on Erythropoietin Secretion
Androgens increase EPO production, finasteride doesn't significantly impact it.
research Finasteride, A Steroid 5α-Reductase Inhibitor, Does Not Affect the Oxidative Metabolism of Antipyrine
Finasteride doesn't affect antipyrine metabolism, so interactions with cytochrome P-450 enzyme drugs are unlikely.
research Finasteride Blocks Progesterone Synthesis in MA-10 Leydig Tumor Cells
Finasteride blocks progesterone production in specific tumor cells, potentially causing side effects.
research Urticarial Rash Due to Finasteride
Finasteride can cause skin rash.
research Leydig Cell Hyperplasia and Adenomas in Mice Treated with Finasteride, a 5α-Reductase Inhibitor: A Possible Mechanism
Finasteride causes abnormal growth in male mice cells at high doses.
research Matrix Matching in Quantitative Bioanalysis by LC-MS/MS: A Dream or a Reality?
Accurate quantitative bioanalysis using LC-MS/MS is challenging due to matrix effects, but using internal standards and new methods like in-sample calibration could improve results.
research Delusions of Parasitosis: World Perspective on the Choice of Psychopharmacotherapy
Clofazimine effectively treated a rare skin condition with ash-gray patches.
research Utilização De Finasterida No Tratamento Da Hiperplasia Prostática Benigna – Relato De Caso
Finasteride effectively treats BPH but requires continuous use to maintain benefits.
research A Simple Decision Tree for Identifying Early Oral Drug Candidates With Likely Pharmacokinetic Nonlinearity by Intestinal CYP3A Saturation
The decision tree can predict drug absorption issues with good accuracy but needs more validation and adjustments for other factors.
research Factors Driving Unique Urination Phenotypes of Male and Female 9-Week-Old C57BL/6J Mice
Testosterone significantly affects urination differences between male and female mice.
research The Prospective Cutaneous Lymphoma International Prognostic Index (PROCLIPI) Study Identifies Clinical Prognostic Markers and Establishes the Foundation for Large-Scale Translational Research in Cutaneous Lymphoma
The PROCLIPI study found markers that help predict outcomes in skin lymphoma patients.
research Association of Demographic and Hospital Characteristics with Emergency Department Visits Due to Sunburn
Young, lower-income men are more likely to visit the emergency department for severe sunburns, especially in the summer and on weekends.
research Association of Melanoma Mortality Rates and Geographic Density of Dermatology and Hematology-Oncology Specialists
More dermatologists in an area are linked to better survival rates for melanoma.
research Cortexolone 17a-Propionate: Preclinical Profile of a New Topical, Skin Selective, Steroidal Antiandrogen
Clofazimine may be effective for treating ashy dermatosis.
research Ashy Dermatosis: Treatment with Clofazimine
Clofazimine successfully treated a man's ashy dermatosis, clearing his skin lesions.
research Baseline Methotrexate Does Not Impact the Incidence of Infliximab Infusion Reactions: Results from a Canadian Real-World Treatment Registry
Clofazimine effectively treated ashy dermatosis in a patient.
research In Vivo and In Vitro Exposure to Free Fatty Acids Induce Increased Androgen Production in Animal Models: A Potential Pathogenic Factor of Polycystic Ovary Syndrome
Free fatty acids may increase androgen production, potentially contributing to polycystic ovary syndrome.
research Hyperandrogenemia in an Ethnically Heterogeneous Cohort of Midwestern United States Diabetic Pregnancies
Exposure to fatty acids significantly increased androgen levels in female dogs, suggesting a link to conditions like insulin resistance and PCOS.
research Annotated Patent Selections
The document highlights various patents for new compounds with potential treatments for multiple diseases, including cancer, hormonal disorders, and diabetes.