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This review highlights new perspectives in genomics and epigenomics for skin rejuvenation, comparing innovative strategies like senolytics and DNA repair modulators with classical treatments, and emphasizing the importance of tailoring therapies using individual genomic profiles for personalized anti-ageing approaches.

In this study, researchers identified a specific DNA aptamer, Ap.OR2AT4.17, that effectively prolonged hair growth and increased hair shaft elongation in organ-cultured human hair follicles by targeting the olfactory receptor OR2AT4. This finding suggests the aptamer's potential as a novel therapy for hair loss disorders.

This study found that Epiprofin acts as a negative regulator of parathyroid hormone transcription, with potential implications for controlling PTH production in hyperparathyroidism.

This review summarizes recent findings on the role of mesenchymal stem cell-derived exosomal microRNAs in skin regeneration and rejuvenation, discussing their potential for treating skin damage and aging, and exploring bioengineering methods to enhance therapeutic effects.

The researchers reviewed the status, challenges, and future prospects of CRISPR/Cas9-mediated gene-editing technology in livestock breeding, noting its benefits and highlighting concerns about low efficiency in inserting foreign genes and off-target effects.

This study aimed to investigate the effects of antioxidant therapy on skin aging in MetS patients in Latvia but provides no new findings on its effectiveness.

This study found that UV radiation-induced fibroblast depletion in the skin is primarily due to a deregulated inflammatory response, with T cells aiding fibroblast survival under stress.

This study found that overexpression of ovine β-catenin in transgenic mice increased hair follicle density by promoting the transition from catagen to anagen.

This article reviews the functions and locations of skin stem cells and their role in regeneration and differentiation, relating age-associated skin changes to decreased stem cell functionality; it reports no new experimental findings.

This study investigated the epigenetic effects of finasteride on reproductive signaling pathways using Sertoli cell models and found that finasteride exposure led to altered epigenetic profiles in multiple genes, including ESR1 and DNMT3A, indicating potential impacts on reproductive-related pathways.

In this study, researchers found that finasteride induces dysregulation of genes related to neuropsychiatric disorders, including the HOMER-3 gene associated with dementia, and propose exploring craniosacral osteopathic therapy's potential to modulate this gene's methylation profile and alleviate related symptoms.

In this study, researchers observed that Finasteride improved cardiac function by enhancing antioxidant levels and reducing oxidative stress in obese and aging rats, though it did not benefit metabolic status and induced insulin resistance in normal diet-fed rats.

This thesis developed stimuli-responsive nanocarriers, demonstrating their potential for targeted genetic material delivery with reduced toxicity and diagnostic applications, and explored pH-sensitive nanogels for effective skin drug delivery and monitoring.

In this study, researchers found that deleting the ATR gene in adult mice led to signs of premature aging and reduced capacity for tissue renewal.

This review summarizes current literature associating mitochondrial dysfunction with dermatologic issues like skin aging, hair loss, and poor wound healing, noting potential benefits in targeting mitochondrial components for treatments.

This article reviews the role of vitamin D receptor in protecting the skin from UV radiation-induced damage and tumor formation, but it reports no new clinical results.

This study found that intermittent treatment with FTI lonafarnib and sulforaphane may be a promising therapeutic approach for children with Hutchinson-Gilford progeria syndrome, as it improved the cellular phenotype.

This study found that transient activation of c-Myc in transgenic mice stimulates keratinocyte proliferation and sebocyte differentiation, affecting normal epidermal and hair follicle development.

This study found that specific gene expressions during different stages of hair follicle development in Merino sheep are linked to wool-related traits, and may also be relevant to human skin, metabolic, and immune traits.

This study found that organ-cultured human scalp hair follicles can mimic chemotherapy-induced damage in vivo and serve as a model to explore molecular targets and protective agents for hair follicle preservation.

This review study focused on various in vitro methods to evaluate skin permeation and retention of sunscreens, highlighting the importance of assessing sunscreen penetration due to widespread nanomaterial usage and advancements in cosmetic formulation.

This study identified mutations in the SNRPE gene that may disrupt hair growth, linking a spliceosome component to hereditary hair loss disorders.

This article reviews how anatomical differences in skin arise and persist, and suggests the underlying molecular positional code is more complex than apparent, but reports no new research findings.

This review discusses the potential of mesenchymal stem/stromal cells and their exosomes in promoting wound healing and skin regeneration, but reports no new experimental results.

This study found that high exposure to air pollutants like SO2, NO, NO2, NOx, and PM2.5 was linked to a significantly increased risk of developing PCOS in women.

This study found that domestic temporary hair dyes may pose a health risk due to their cytotoxic effects on human red blood cells and NIH/3T3 cell lines.

This study found that while zebularine did not significantly accelerate wound healing, it improved the quality of restored skin in mice, suggesting potential for further research into epigenetic inhibitors.

This study identified key regions and transcription factors, including SIX1 and FOXN1 itself, that regulate Foxn1 expression in thymic epithelial cells and hair follicle cells, offering insights into its transcriptional regulation.

This review explores the detrimental effects of sunlight on the skin’s circadian rhythm and photodamage, noting the potential of natural cosmeceuticals to influence this rhythm, but reports no new results.

This study analyzed the transcriptome of the Tianzhu white yak, identifying differential transcripts that shed light on the molecular mechanisms influencing hair length growth variation in this species.