17 citations
,
March 2012 in “The Journal of Pathology” This article argues that lineage labeling with genetic markers is the gold standard for identifying epithelial stem cells, contrary to the view that in vitro methods alone are sufficient.
15 citations
,
February 2021 in “Cells” This study concluded that using human umbilical cord blood mononuclear cells transfected with VEGF and FGF2 genes enhances skin wound healing in rats, demonstrating greater wound revascularization compared to controls.
7 citations
,
August 2020 in “Current topics in medicinal chemistry” This review discusses emerging cancer treatment methods focusing on cellular mechanisms unique to cancer cells and concludes no new clinical results.
February 2025 in “Intisari Sains Medis” This article explores the potential mechanisms by which polydeoxyribonucleotide (PDRN) could improve skin quality, slow aging, and enhance skin regeneration, but reports no new clinical findings.
24 citations
,
September 2023 in “Science Advances” In this study, deleting the gene Mettl3 in mouse epidermal progenitors resulted in impaired epithelial development and self-renewal, highlighting m6A's crucial role in regulating chromatin modifiers and maintaining normal epithelial tissue function.
16 citations
,
August 2022 in “Nature Communications” In this study, researchers discovered that ROR2, a Wnt receptor, plays a crucial role in regulating hair follicle stem cell self-renewal and maintenance, compensating for the absence of β-catenin.
July 2026 in “Regenerative Biomaterials” This study found that modifying biphasic calcium phosphate/poly(methyl methacrylate) bone cement with human hair keratin improves its hydrophilicity, mechanical properties, and supports bone repair in rats, indicating potential for orthopedic applications.
34 citations
,
November 2020 in “Biomedical Physics & Engineering Express” This study observed that using DNA nanostructures to deliver chemotherapy drugs could potentially reduce costs compared to traditional methods, with financial barriers being less significant than technical, regulatory, and ethical challenges.
15 citations
,
June 2021 in “Journal of Genetic Engineering and Biotechnology” This review explores biomaterials in non-viral gene delivery systems and highlights the need for more research to better understand how various parameters affect gene delivery processes, without reporting new experimental results.
This review summarizes the composition, bioactive functions, and potential industrial applications of rice bran polysaccharides, focusing on how extraction methods and modifications impact their biological activities.
2 citations
,
February 2025 in “Journal of Nanobiotechnology” In this study, metal-organic frameworks modified with stearic acid were used to deliver cardamonin to hair follicles, significantly promoting hair growth and cell proliferation in testosterone-challenged mice, suggesting potential benefits for androgenic alopecia treatment.
9 citations
,
January 2021 in “Mediators of Inflammation” In this study, 15d-PGJ2 administered in a topical cream inhibited oxidative and inflammatory skin changes caused by UVB radiation in hairless mice, suggesting it as a promising treatment approach.
August 2026 in “The FASEB Journal” This study identified two key epigenetic-related genes, HR and SMYD4, which may act as potential biomarkers in keloid disease, suggesting new therapeutic avenues for further research.
5 citations
,
December 2021 in “Frontiers in Cell and Developmental Biology” This review outlines how peptidyl arginine deiminases (PADIs) and protein citrullination are involved in hair follicle regeneration and inflammatory alopecia, but presents no new clinical findings.
December 2023 in “Forensic science international. Genetics” This study found that the RapidHIT™ ID system can successfully obtain DNA profiles from single hair roots, particularly those with high nuclei counts.
21 citations
,
January 2022 in “Biomaterials Science” This article reviews CRISPR/Cas system delivery methods for genome editing and highlights RNA's promise in non-viral in vivo applications but reports no new clinical results.
1 citations
,
November 2024 in “Orphanet Journal of Rare Diseases” Changes in genes FGA, VWF, and ACTG1 may contribute to pemphigus vulgaris.
28 citations
,
November 2018 in “Journal of Cellular and Molecular Medicine” This review discusses the role of the CXXC5 protein as a transcription factor and signaling coordinator, noting its involvement in embryonic development, tissue homeostasis, and diseases such as tumorigenesis, but reports no new experimental findings.
51 citations
,
September 2008 in “Journal of Investigative Dermatology” This article reviews the role of vitamin D receptor in protecting the skin from UV radiation-induced damage and tumor formation, but it reports no new clinical results.
50 citations
,
July 1996 in “Cell” This review discusses genetic and epigenetic mechanisms that may contribute to aging and presents models suggesting that chromosomal changes could play a key role in the aging process; it reports no new experimental findings.
39 citations
,
January 2020 in “Frontiers in Genetics” This study found that stage-specific epigenetic changes, particularly involving the gene PDGFC, may affect wool fiber development in Zhongwei goats, potentially serving as a biomarker for fur goat selection.
32 citations
,
July 2017 in “Oncotarget” This study found that intermittent treatment with FTI lonafarnib and sulforaphane may be a promising therapeutic approach for children with Hutchinson-Gilford progeria syndrome, as it improved the cellular phenotype.
13 citations
,
December 2017 in “Stem cells” This study found that in mice, low-dose irradiation causes stem cells in hair follicles to undergo chromatin alterations, which may eventually lead to long-term functional loss in tissues or organs.
5 citations
,
January 1981 This article reviews the classification and complexity of keratin protein groups in hair follicles, but reports no new experimental results on their transcriptional events.
May 2026 in “Nature Communications” This study observed that the loss of H3K9me3, via the ablation of Suv39h1, Suv39h2, and Setdb1 in embryonic mouse epidermis, disrupts skin development processes such as keratinocyte differentiation and hair follicle formation, highlighting H3K9me3's crucial role in epidermal morphogenesis.
March 2026 in “Scientific Data” This study mapped the genome-wide epigenetic landscape in secondary hair follicle stem cells of goats, revealing distinct histone modification signatures associated with cashmere fiber cycling during different stages of hair growth.
In this review, researchers discussed the development, challenges, and future prospects of using CRISPR/Cas9 gene editing technology in livestock breeding, highlighting its current limitations in precise gene insertion and off-target effects, particularly in large livestock like cashmere goats.
61 citations
,
January 2011 in “PloS one” In this study, researchers found that Notch signaling is crucial for late-stage epidermal differentiation and postnatal hair cycle homeostasis by regulating hair follicle stem cell proliferation and differentiation.
2 citations
,
January 2016 in “Sarcoma” This study found that using a recombinant adenoassociated virus to induce survivin expression protected normal tissues from radiation damage in mice, reducing side effects compared to controls.
May 2022 in “The FASEB Journal” This experimental study suggests that finasteride may reduce Lymphocyte Specific Protein 1 gene expression through methylation in human Leydig cells, potentially offering a pathway for treating Neutrophil Actin Dysfunction.