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SETDB1 is essential for controlling DNA methylation, silencing retrotransposons, and maintaining skin cell health, with its absence leading to skin inflammation and hair loss.

Maintaining DNA integrity in stem cells is crucial to prevent aging and cancer.

Hair loss in balding individuals is linked to changes in specific hair growth-related genes.

Skin cell types develop when specific genes are turned on by removing certain chemical tags from DNA.

Melatonin may benefit skin health and could be a promising treatment in dermatology.

Melatonin helps regulate hair growth and protects the hair follicle from stress.

The balance between androgen receptor and p53 is crucial for sebaceous gland differentiation.

Melatonin protects skin against UV damage by regulating various cellular processes.

Human skin can make serotonin and melatonin.

Dermal EZH2 controls skin cell development and hair growth in mice.

Melatonin, a hormone, can help protect skin from aging by reducing stress, inflammation, and damage, and may also help treat hair loss in women.

CRISPR/Cas9 gene-editing shows promise for improving sheep and goat breeding but faces challenges with efficiency and accuracy.

ASH2L is essential for skin and hair development.

Studying premature aging syndromes helps understand human aging and suggests potential treatments.

Molecular diagnostics help identify genetic defects causing endocrine diseases, improving diagnosis and treatment options.

The document concludes that while there are promising methods to control CRISPR/Cas9 gene editing, more research is needed to overcome challenges related to safety and effectiveness for clinical use.

Azathioprine's effectiveness and safety require careful monitoring and more research, especially regarding its use with corticosteroids and the role of TPMT status in patients.

Cell aging can be both good and bad for tissue repair.

The NUDT15 gene variant causes severe side effects from azathioprine in some Indian patients.

Skin's epithelial stem cells are crucial for repair and maintenance, and understanding them could improve treatments for skin problems.

NF-κB signaling is crucial in many diseases and can be targeted for new treatments.

Azathioprine can cause severe blood issues and hair loss, needing careful monitoring and possible discontinuation.

Melatonin is important for skin health and protection, and can be made by the skin or applied to it.

Mouse skin can produce and process serotonin, with variations depending on hair cycle, body location, and mouse strain.

Some natural compounds may help overcome drug resistance in certain cancers, but more research is needed.

Cellular senescence has both cancer-blocking and cancer-promoting effects, and targeting senescent cells may improve health and lifespan.

Rat dermal papilla cells have unique genes crucial for hair growth.

Hair and skin can regenerate without bulge stem cells due to other compensating cells.

Melatonin receptors in hair follicles help regulate hair growth and could treat hair loss.

A man with multiple autoimmune diseases developed liver injury from azathioprine, but his liver improved after stopping the drug.