321 citations,
January 2012 in “Cell stem cell” TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.
224 citations,
February 2013 in “The Journal of clinical investigation/The journal of clinical investigation” ERG increases SOX9, promoting prostate cancer growth and invasion.
205 citations,
September 2018 in “Nutrients” Essential oils from Curcuma species, like turmeric, have compounds that can fight inflammation, cancer, and bacteria, and can also stimulate hair regrowth in bald males.
132 citations,
August 2008 in “Development” Dlx3 is essential for hair growth and regeneration.
127 citations,
January 2008 in “PloS one” Vitamin D receptor helps control hair growth and could be used to treat certain skin tumors.
127 citations,
January 2000 in “Journal of Investigative Dermatology” Cytotoxic T cells cause hair loss in chronic alopecia areata.
111 citations,
August 1998 in “Journal of Investigative Dermatology” μ-opiate receptors in skin cells may affect skin health and healing.
109 citations,
February 2018 in “CB/Current biology” ERULUS controls root hair growth by regulating cell wall composition and pectin activity.
96 citations,
March 2007 in “Developmental biology” The study found that the protein Dkk4 helps regulate hair growth by controlling Wnt signaling in mice.
72 citations,
June 2019 in “International Journal of Cosmetic Science” 18β-glycyrrhetinic acid from licorice root is good for skin and hair treatments but has absorption challenges.
70 citations,
February 2016 in “EMBO reports” Scientists found a specific group of itch-sensing nerve cells in mice important for feeling itch but not for sensing heat or touch.
65 citations,
September 2014 in “BMC genomics” Different hair types in mammals are linked to variations in specific protein genes, with changes influenced by their living environments.
55 citations,
August 2013 in “PloS one” Genetic differences between young and old Tan sheep explain why their fleece changes from curly to straight as they age.
52 citations,
May 2011 in “APOPTOSIS” Hydroxyl radicals cause hair follicle cell death during chemotherapy by reducing Bcl-2 protein levels.
42 citations,
May 2007 in “Endocrinology and metabolism/American journal of physiology: endocrinology and metabolism” Testosterone can build muscle and bone without enlarging the prostate when a specific enzyme is blocked.
36 citations,
August 2022 in “Molecular Therapy — Nucleic Acids” Gene therapy shows promise for healing chronic wounds but needs more research to overcome challenges.
36 citations,
March 2014 in “Molecular and Cellular Biology” Cidea is essential for proper lipid storage and secretion in sebaceous glands, affecting skin and hair health.
35 citations,
June 2012 in “PloS one” Keratin 15 expression in skin cells is regulated by two mechanisms involving PKC/AP-1 and FOXM1.
35 citations,
August 2009 in “Differentiation” Desmoglein 4 is controlled by specific proteins that affect hair growth.
31 citations,
August 2021 in “Stem Cell Research & Therapy” The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.
25 citations,
October 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Mouse profilaggrin helps in skin cell differentiation and may be involved in calcium signaling.
19 citations,
July 2020 in “EBioMedicine” A gene variant increases the risk of a type of hair loss by affecting hair protein production.
18 citations,
November 2012 in “Current opinion in urology” Finasteride and dutasteride are equally effective and safe for treating benign prostatic hyperplasia.
17 citations,
May 2012 in “Journal of biological chemistry/The Journal of biological chemistry” Hairless protein affects hair follicle structure by regulating the Dlx3 gene.
17 citations,
May 2018 in “BMC genomics” Researchers found genes and microRNAs that control curly fleece in Chinese Tan sheep.
16 citations,
September 2006 in “The Journal of Immunology” MILL molecules are unique immune proteins in mice that don't need TAP to appear on cell surfaces.
16 citations,
November 2021 in “Antioxidants” Managing oxidative stress might help treat low testosterone and related chronic diseases in aging men.
16 citations,
January 2017 in “Asian journal of andrology/Asian Journal of Andrology” Men who start puberty later may have lower sperm quality and different hormone levels in adulthood.
15 citations,
August 2010 in “Fertility and sterility” Metformin works better for adolescent girls with PCOS who have certain genetic variations.
14 citations,
May 2020 in “Archiv für Tierzucht” Researchers identified genes that may affect hair growth in Cashmere goats.