Hairlessness in mammals is due to complex genetic changes in both genes and regulatory regions.
January 2020 in “International Journal of Applied Biology and P” Finasteride treatment for three years changes certain polyamine levels in the blood but not in urine.
54 citations,
June 1985 in “American Journal of Dermatopathology” Minoxidil helps grow longer, thicker hair in bald scalps of stumptailed macaques, and early treatment is more effective.
13 citations,
October 2019 in “Journal of lasers in medical sciences” CO2 laser treatment for aging skin significantly changes immune system-related genes.
8 citations,
January 2020 in “PeerJ” Alopecia Areata causes significant structural and compositional changes in hair.
4 citations,
November 2021 in “Frontiers in Cell and Developmental Biology” Aging causes hair loss and graying due to stem cell decline and changes in cell behavior and communication.
467 citations,
May 1999 in “Molecular Cell” Activating c-Myc in skin causes rapid cell growth and changes, but these effects are reversible.
57 citations,
July 2005 in “Genetics” Key genes are crucial for Drosophila wing development and could be insecticide targets.
55 citations,
August 2013 in “PloS one” Genetic differences between young and old Tan sheep explain why their fleece changes from curly to straight as they age.
28 citations,
June 2015 in “Journal of circadian rhythms” An individual's morning or evening preference can predict changes in their body clock gene expression.
9 citations,
February 2021 in “Frontiers in Cell and Developmental Biology” Older mice have stiffer skin with less elasticity due to changes in collagen and skin structure, affecting aging and hair loss.
6 citations,
January 2021 in “International Journal of Molecular Sciences” Finasteride-treated male rats' offspring had altered glucose metabolism, potentially increasing diabetes risk.
6 citations,
May 2020 in “Nutrients” Eating fewer calories may slow skin aging and improve skin health through various biological changes.
3 citations,
March 2023 in “International journal of molecular sciences” Keratin protein production in cells is controlled by a complex system that changes with cell type, health, and conditions like injury or cancer.
December 2020 in “The journal of investigative dermatology/Journal of investigative dermatology” Papulopustular rosacea is an inflammatory skin condition treatable with lifestyle changes and medications.
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” Mouse skin glands need healthy nerves to grow properly during hair growth phases.
18 citations,
January 2018 in “Advances in experimental medicine and biology” Hair keratins evolved from ancient proteins, diversifying through gene changes, crucial for forming claws and later hair in mammals.
9 citations,
May 2002 in “PubMed” Retinoic acid affects skin and hair health by working with specific receptors, and its absence can lead to hair loss and skin changes.
April 2021 in “Journal of Investigative Dermatology” Leontopodium alpinum extract may help reduce hair shedding by keeping hair in the growth phase longer.
August 2015 in “Free Radical Biology and Medicine” Nrf2 helps protect skin from damage but too much can cause skin problems.
317 citations,
April 2018 in “Journal of steroid biochemistry and molecular biology/The Journal of steroid biochemistry and molecular biology” PCOS is a complex condition in women that can lead to health issues, and lifestyle changes are the best management approach.
204 citations,
October 1999 in “EMBO journal” Overexpression of activin A in mice skin causes skin thickening, fibrosis, and improved wound healing.
104 citations,
January 2005 in “Climacteric” Drospirenone is a unique progestin with anti-water retention and potential blood pressure benefits, used in birth control and hormone therapy.
99 citations,
June 2005 in “Journal of Cosmetic Dermatology” Hair ages due to genetics and environmental factors, leading to graying and thinning, with treatments available for some conditions.
65 citations,
September 2014 in “BMC genomics” Different hair types in mammals are linked to variations in specific protein genes, with changes influenced by their living environments.
43 citations,
September 2001 in “Scanning” Hair treatments like bleaching increase friction by exposing tiny pores on the hair surface.
36 citations,
June 2014 in “PLOS ONE” Finasteride, a hair loss drug, may cause long-term sexual side effects due to changes in hormone receptor levels.
27 citations,
December 2014 in “Current problems in dermatology” Photodynamic therapy is the preferred treatment for skin precancer due to its effectiveness and safety.
24 citations,
March 2015 in “Best Practice & Research in Clinical Obstetrics & Gynaecology” Some skin conditions are common during pregnancy and can be safely treated without affecting the pregnancy outcome.
22 citations,
August 2013 in “PLOS ONE” The method safely and efficiently delivers genes to the skin but may not work for conditions needing high levels of gene products.