86 citations
,
July 2020 in “International Journal of Molecular Sciences” This review discusses the role of Wnt/β-catenin signaling in hair follicle regeneration and highlights recent progress in developing hair loss treatments targeting this pathway, but reports no new clinical results.
49 citations
,
April 2012 in “Phytotherapy Research” This study found that topical Rosmarinus officinalis leaf extract improved hair regrowth in mice and inhibited androgen-associated mechanisms involved in hair loss.
3 citations
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August 2013 in “Stem cells” This study found that topical application of partial proteasomal inhibitors accelerates hair growth by stabilizing β-catenin and disrupting the hair cycle's normal balance of activation and quiescence.
2 citations
,
May 2024 in “The World Journal of Men s Health” This cohort study using real-world data found no significant difference in the risk of developing prostate cancer between finasteride and dutasteride among patients with benign prostatic hyperplasia, despite previous suggestions that dutasteride might be more effective.
2 citations
,
February 2024 in “Nature cell biology” In this research, the authors identify coordinated mechanical forces as crucial for hair follicle development in mammals, with contractile, proliferative, and proteolytic activities facilitating the formation and sectioning of epithelial structures crucial for forming a functional tissue.
1 citations
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January 2021 in “JIFFK Jurnal Ilmu Farmasi dan Farmasi Klinik” In this study, the researchers found that while the chitosan-alginate gel base supported hair growth, the addition of 0.5% celery extract did not enhance growth, likely due to its low concentration.
In this study, researchers identified three novel genetic loci associated with androgenetic alopecia, including one with significant association in females only, which may indicate a role for sex-specific genetic factors in patterned hair loss.
November 2022 in “Gigascience” This study identified a 582-bp deletion upstream of LHX2 in cashmere goats, likely linked to hair follicle development and cashmere production, providing insights into genetic factors in cashmere trait selection.
100 citations
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September 2017 in “Molecular and Cellular Endocrinology” This review discusses the molecular mechanisms of androgens and androgen receptors in skin disorders, particularly androgenetic alopecia, and reports no new clinical results; it highlights potential areas for future treatment development.
25 citations
,
July 2019 in “Experimental Dermatology” This review discusses the role of cholesterol homeostasis in hair follicle biology and its potential connections to various hair disorders, but it reports no new findings.
April 2021 in “MEDICINUS” This case report describes a 5-year-old boy with acquired acrodermatitis enteropathica and normal serum zinc levels, improving clinically after zinc supplementation.
60 citations
,
September 2016 in “Dermatologic Surgery” This article proposes a mechanistic model for how platelet-rich plasma therapy may stimulate hair growth in androgenetic alopecia by promoting vascularization and activating specific signaling pathways, but it reports no new experimental results.
1 citations
,
January 2022 in “Indonesian Journal of Pharmaceutical Science and Technology” This study evaluated a 20% cinchona extract cream and found it increased hair growth length and mass in guinea pigs, demonstrated good physical stability, and did not irritate rabbit skin.
39 citations
,
March 2018 in “Archives of Dermatological Research” This review describes the molecular interactions between androgens and Wnt/ß-catenin signaling in androgenetic alopecia but reports no new experimental or clinical findings; the authors discuss potential Wnt/ß-catenin-targeted treatments for hair growth.
829 citations
,
May 2007 in “Nature” Hair follicles can regrow in wounded adult mouse skin using a process like embryo development.
48 citations
,
July 2008 in “Acta Biochimica et Biophysica Sinica” This review discusses the roles and mechanisms of Wnt signaling in embryonic and adult stem cells and its association with cancers, and reports no new experimental findings.
3 citations
,
January 2022 in “Scientific Reports” This study found that SAMiRNA-AR68, a nanomedicine targeting androgen receptor mRNA, increased hair counts in androgenetic alopecia patients with no observed side effects.
3 citations
,
November 2020 in “Biological Trace Element Research” This study found that patients with androgenetic alopecia had deficiencies in certain trace elements and vitamins, which were linked to distinct patterns of hair loss connected to androgen levels.
1 citations
,
May 2023 in “Frontiers in Pharmacology” This study found that millet seed oil effectively promoted hair growth in a mouse model with testosterone-induced hair growth inhibition, suggesting its potential use in preventing or treating androgenetic alopecia.
March 2025 in “Journal of Cutaneous and Aesthetic Surgery” In this study, three different hair serums were tested for their impact on Telogen effluvium in adult females, finding all effective in reducing hair shedding, with the cytokine-based serum showing the most significant improvement, reducing hair fall by 54.6% without adverse effects.
February 2024 in “Skin Research and Technology” This study found that combining scalp repair serum microneedles with oral and topical medications significantly improved hair regrowth in patients with moderate to severe androgenetic alopecia.
September 2023 in “Frontiers in Medicine” This study observed that in the bald scalps of male patients with androgenetic alopecia, there was a significant downregulation of the PPAR signaling pathway, suggesting reduced adipogenesis potentially influencing hair cycling processes.
This study tested a natural hair dye made from papaya seed extract, celery leaf, and avocado, finding color change in animal hair but also noting tissue changes like hyperkeratosis.
1 citations
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September 2023 in “Journal of cosmetic dermatology” This study suggests that Silybum marianum flower extract may promote hair growth and reduce hair loss by increasing proliferation and VEGF production in dermal papilla cells and suppressing cell senescence.
January 2026 in “Cosmetics” In this study, yeast fermentation of Platycladus orientalis leaves was shown to enhance hair growth-promoting properties by affecting cell cycle phases in human dermal papilla cells, increasing growth factor VEGF, reducing inflammatory factor TGF-β1, and altering the expression of Wnt/β-catenin pathway-related genes.
November 2025 in “Cosmetics” This study found that of the many ingredients advertised in shampoos as effective against hair loss, only caffeine, adenosine, placental proteins, and melatonin have limited clinical evidence supporting their efficacy, with most claimed active ingredients lacking any trial-based validation.
May 2024 in “Jurnal Penelitian Farmasi dan Herbal” In this experimental study using male rabbits, researchers found that a 7.5% concentration of green tea leaf ethanol extract hair tonic was nearly as effective in promoting hair growth as the positive control, minoxidil, over a 21-day period.
March 2022 in “Clinical Cosmetic and Investigational Dermatology” This study identified altered mRNA and lncRNA profiles in NS scalp tissues, highlighting CDKN2AIP as a downregulated gene involved in a ceRNA network.
3 citations
,
August 2022 in “International Journal of Molecular Sciences” This review discusses the increased incidence of hair loss and telogen effluvium among COVID-19 patients and evaluates existing evidence for regenerative treatments like PRP and HFSCs, finding limited published data.
3 citations
,
June 2021 in “PLOS ONE” This study found that topical application of the BRAF inhibitor vemurafenib improved wound healing and promoted hair follicle regeneration in a diabetic murine model.