Search for dihydrofolate reductase in research

Cloning, Expression, and Characterization of Rhesus Macaque Types 1 and 2 5alpha-Reductase: Evidence for Mechanism-Based Inhibition by Finasteride

research Cloning, expression and characterization of rhesus macaque types 1 and 2 5alpha-Reductase: evidence for mechanism-Based inhibition by finasteride

25 citations , September 1998 in “The Journal of Steroid Biochemistry and Molecular Biology”

This study concludes that rhesus macaques are a suitable model for testing the pharmacological properties of finasteride and other 5aR inhibitors, due to their biochemical similarity to humans.

HIF1A Stabilization in the Human Hair Follicle Promotes Glycolysis

research 1328 HIF1A stabilisation in the human hair follicle promotes glycolysis

April 2018 in “Journal of Investigative Dermatology”

In this study, researchers found that stabilizing the protein HIF1A in hair follicles promotes glycolysis over oxidative phosphorylation, potentially reducing oxidative stress and supporting hair growth.

Is There an Association Between 5α-Reductase Inhibitors and Metabolic Syndrome? A Narrative Review of the Literature

research Is There an Association between 5a Reductase Inhibitors and Metabolic Syndrome? A Narrative Review of the Literature

June 2024 in “Reviews on Recent Clinical Trials”

This review analyzed current research on finasteride and dutasteride and found insufficient evidence to fully elucidate their role in metabolic adverse events, such as liver disease and diabetes, due to a lack of detailed pathophysiologic understanding; further studies are needed to clarify these mechanisms.

research Hereditary 1,25-dihydroxyvitamin D-resistant rickets with alopecia resulting from a novel missense mutation in the DNA-binding domain of the vitamin D receptor

50 citations , September 2009 in “Molecular Genetics and Metabolism”

This study identified a novel V26M mutation in the vitamin D receptor as the cause of hereditary vitamin D resistant rickets in a patient, characterized by severe rickets and an unusual pattern of alopecia.

research Women Also Use 5α-Reductase Inhibitors

November 2017 in “JAMA internal medicine”

This letter to the editor states that the titles of two recent pieces in JAMA Internal Medicine should have included "in Men.