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This review explores the use of topical and transdermal delivery for drugs and cosmetics, highlighting the benefits of avoiding side effects and rapid metabolism, with a focus on nanoparticulate formulations and techniques for studying skin penetration.

In this study, researchers developed a new self-administered finasteride delivery system using powder-carrying microneedles that improved hair growth efficacy and addressed safety concerns compared to topical finasteride gel by allowing sustained intradermal release of the drug for three days with a single application.

This study found that radiation negatively impacts the survival and proliferation of fibroblasts on human dermis transplants, but hair follicle pores enhance cell viability even after irradiation.

In this study, researchers developed a method using stencils to create controlled stiffness gradients in alginate hydrogels, revealing that stiffer regions within the gels promote deeper invasion by breast cancer cells, facilitating the study of mechanosensitive cellular behaviors.

This study describes the process of isolating and analyzing multipotent stem cells from mouse hair follicles for potential use in tissue engineering and regenerative medicine.

This study found that African and Caucasian hair contain the most lipids, and depletion of these lipids leads to less water retention and increased water desorption, with Caucasian hair showing improved breaking tenacity after lipid extraction.

In this study, the authors found that applying hypobaric pressure to the skin significantly increases the transdermal permeation of large molecules by enhancing diffusion, despite the associated skin stretching and hair follicle enlargement not fully explaining this effect.

This study found that a mutation in the BMP12/GDF7 gene is associated with the Naked neck trait in chickens, reducing neck feathering due to altered signaling pathways.

This study found that using short durations of heat with chemical penetration enhancers improved isotretinoin delivery to human skin, especially via the hair follicles.

The study reported that combining the Follicular Closing Technique with the Franz diffusion cell is a valuable method for investigating follicular caffeine penetration in vitro, though kinetics differ from in vivo results.

This study found that nanostructured lipid carriers provided better skin-targeted delivery and drug loading for lidocaine than nanoethosomes, indicating improved local anesthetic efficacy in vitro.

This study found that minoxidil was released 50% less from creams than from lotions, with a similar release profile across different lotion formulations, suggesting a specific vehicle composition for topical use.

This study concluded that the follicular route is a significant pathway for delivering gentamicin through the skin, as demonstrated by higher drug permeation in non-plugged pig's ear skin compared to plugged skin.

This study found that hair follicle patterning in development may arise from a combination of epidermal prepattern signals and mesenchymal self-organisation, with fibroblast growth factor and bone morphogenetic protein activities playing key roles.

In this study, researchers found that the lipid composition in hair significantly affects water diffusion and may explain differences in dyeing and cosmetic treatment responses between Asian and European hair, with CP2 fibers having more lipids than CP3 fibers.

This study explored the in vitro skin penetration of two compounds from Tectona grandis leaf extract used for standardization and found that compound 1 penetrates more efficiently than compound 2, especially with a propylene glycol enhancer.

This study suggests that topically applied fusidic acid may penetrate only the most superficial layers of canine skin but can reach sufficient concentrations to potentially treat infections caused by pathogenic staphylococci.

This systematic review indicates that a platelet-rich plasma concentration of 1.0 × 10^6 plt/μL may be optimal for tissue regeneration due to sufficient nutrition supply and effective growth factor diffusion in vivo.

In this study, researchers found that human fingerprint ridges are formed through a modified hair follicle developmental process and spatial patterns influenced by specific signaling pathways.

This study developed dissolving microneedles using specific polymers for transdermal delivery of rizatriptan benzoate, demonstrating improved drug skin penetration and significant alleviation of migraine symptoms in vivo compared to passive diffusion, suggesting potential advantages over conventional treatment methods for acute migraine.

This study found that lipid extraction increased water diffusion in wool and hair fibers; the effect was more pronounced in hair, indicating lipids are crucial for water permeability.

The researchers reported that caprylic acid effectively enhances the permeability and diffusion of minoxidil through rat skin compared to other penetration enhancers.

This source highlights the utility of cationic polymers in haircare products for protecting against hair damage from chemical treatments and grooming, and describes how microfluorometry can measure polymer deposition and penetration on hair fibers.

In this study, peptide-based nanoparticles were successfully used to deliver the CRISPR-Cas9 system into cancer cells, effectively targeting and editing KRAS mutations, suggesting promising therapeutic potential for cancer treatment.

This review discusses the potential of nanocarriers to enhance transdermal drug delivery and the combination of these carriers with physical methods, but it reports no new experimental results.

This mini-review highlights emerging themes on how tissue stiffness, a fundamental material property, influences morphogenetic processes in living organisms, an area gaining increased attention alongside the role of mechanical forces in shaping cell behavior.

This study found that a developed nanostructured lipid carrier formulation of tea seed oil can effectively stimulate hair growth and reduce the oily feeling associated with direct application.

In this study, the authors identified and characterized the Get3d protein, conserved across plants and photosynthetic bacteria, which localizes to the chloroplast in Arabidopsis thaliana and potentially plays a role in tail-anchored protein targeting, linked to photosynthesis homeostasis.

This review discusses nonsurgical techniques for facial masculinization and feminization in transgender patients and reports no new clinical findings, utilizing data from analogous procedures in cisgender individuals.

This article reviews trichotillomania, highlighting its differences from OCD and recommending treatments like habit reversal therapy and specific medications, but reports no new clinical results.