August 2024 in “Stem Cell Research & Therapy” This review discusses current and emerging therapies for androgenetic alopecia, emphasizing regenerative treatments and nanotechnology advancements, but it reports no new clinical results.
February 2024 in “International Journal of Molecular Sciences” This review outlines the functional anatomy, pathology, and molecular mechanisms of androgenetic alopecia, emphasizing the need for multi-omics approaches to better understand this condition's biology.
December 2023 in “Journal of clinical medicine” This study reports the case of an elderly patient with a keratosis pilaris-like skin eruption after beginning treatment with imatinib for chronic myeloid leukemia, discussing similar skin reactions to BCR-ABL inhibitors and exploring potential mechanisms behind these adverse cutaneous reactions.
October 2023 in “Biomaterials” This review highlights the potential of nanotechnology for hair follicle regeneration, focusing on strategies such as hair cycle modulation, progenitor cell stimulation, and wound-induced hair neogenesis, while also discussing regulatory challenges that may affect the development of these innovative approaches.
January 2012 in “Journal of Investigative Dermatology” The document presented various studies on hair and cutaneous development, revealing insights into hair biology and potential therapeutic targets for hair-related conditions. Key findings included the role of stem cells and their niches in hair regeneration, the impact of TACE/ADAM17 depletion on alopecia, and the expression of somatostatin in hair follicles. Research on genetic factors, such as CYLD mutants and P-cadherin, highlighted their importance in hair growth and pigmentation. Studies on hair aging identified genes involved in hair loss in women over 40. Additionally, the potential of keratinocyte precursors from iPS cells for hair follicle regeneration and the effectiveness of a parathyroid hormone analog in reversing chemotherapy-induced alopecia were explored. The document also discussed the role of cholesterol biosynthesis in cicatricial alopecia, the necessity of Wnt signaling for hair follicle initiation, and the effects of ATP-sensitive potassium channel blockers on hair growth. These findings collectively advanced the understanding of hair growth, alopecia treatment, and skin regeneration.
January 2023 in “Journal of Clinical and Diagnostic Research” This study compared the effectiveness and safety of microneedling with PRP versus minoxidil and finasteride topical therapy in adult males with androgenetic alopecia, finding similar hair density improvements in both groups, though microneedling with PRP had a quicker onset of action.
October 2022 in “Journal of Drugs in Dermatology” This study observed that both PRP and 1550 nm fractional erbium-glass laser improved AGA, with greater hair density in patients receiving the combination therapy and no side effects reported.
15 citations
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June 2021 in “Journal of Genetic Engineering and Biotechnology” This review explores biomaterials in non-viral gene delivery systems and highlights the need for more research to better understand how various parameters affect gene delivery processes, without reporting new experimental results.
163 citations
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October 2001 in “EMBO journal” This study found that endogenous activin plays a crucial role in wound healing and scar formation, as its inhibition led to delayed wound healing and reduced scar size in transgenic mice.
154 citations
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November 2017 in “Development” This review discusses the roles of fibroblast growth factors in tissue regeneration and repair across various organisms and tissues, but reports no new experimental findings, underscoring the need for further research.
151 citations
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May 2021 in “Frontiers in Medicine” This systematic review observed that a significant number of COVID-19 patients report long-term symptoms, including neurologic complaints and chronic fatigue, highlighting the presence of "post-COVID syndrome.
96 citations
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September 2021 in “International Journal of Molecular Sciences” This review highlights recent advances in chitosan-based nanoparticles (CS NPs) for drug delivery, discussing their modifications, preparation methods, production with organic and inorganic materials, and their latest implementations in the field, emphasizing the role of CS NPs in improving drug transport and release properties.
61 citations
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April 2023 in “Bioactive Materials” This review article highlights recent advances in microneedle technology for wound healing and tissue regeneration, discussing various cargo types, structural designs, and fabrication methods, and suggesting guidelines for designing microneedle systems tailored to specific applications.
52 citations
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January 2022 in “Current Research in Pharmacology and Drug Discovery” This review highlights ongoing efforts in drug repurposing and development of new therapeutics against COVID-19, emphasizing the promise of these strategies in addressing the challenges posed by SARS-CoV-2 mutations and post-infection complications.
50 citations
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November 2021 in “Viruses” This study observed that in vitro exposure to dihydrotestosterone worsened COVID-19 spike protein-induced endothelial injury, while spironolactone showed potential in reducing this effect, suggesting a rationale for further evaluation in treating COVID-19.
48 citations
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January 2024 in “Frontiers in Pharmacology” This paper reviews strategies to enhance the effectiveness of topical drug delivery by addressing skin barrier challenges, optimizing drug delivery systems, and personalizing treatment approaches, highlighting both current advancements and limitations in the field.
48 citations
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March 2021 in “Frontiers in Cell and Developmental Biology” This review discusses the use of human mesenchymal stem cells (hMSCs) for treating skin diseases and suggests they show promise for improving conditions like wounds and scleroderma, but more research is needed due to varied study designs and endpoints.
35 citations
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May 2023 in “International Journal of Preventive Medicine” This review discusses the various aspects of long COVID, highlighting its multi-organ impact, including symptoms like fatigue and dyspnea, and suggests that vaccination may play a role in prevention and management. Risk factors and potential therapeutic strategies are also examined.
35 citations
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February 2023 in “Journal of Clinical Medicine” This review discusses treatments for demodicosis in adults and children and provides no new clinical results; the authors emphasize the need for careful diagnosis and therapy selection.
35 citations
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December 2020 in “International Journal of Molecular Sciences” This review examines the mixed evidence on mast cells as regulators of skin fibrosis and highlights existing gaps in the scientific understanding, reporting no new experimental results.
21 citations
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March 2025 in “Journal of Extracellular Vesicles” This review discusses how using hydrogels as a three-dimensional culture platform for mesenchymal stem cells might affect the production of extracellular vesicles, highlighting challenges in standardization and opportunities to boost EV yield via combined hydrogels and bioreactor methods.
19 citations
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October 2024 in “Molecular Pharmaceutics” This review discusses the challenges of traditional phytochemical delivery methods and highlights the potential of microneedles to improve intra/transdermal delivery, reporting no new clinical results.
15 citations
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January 2017 in “Polymers” This review discusses how engineering cell surfaces with polyelectrolytes can address challenges in cell therapy and related biomedical fields and reports no new research findings.
13 citations
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March 2024 in “Cell Transplantation” This review highlights the need for improved methods in cosmetic safety assessment, emphasizing the potential of engineered skin tissue for more effective detection and toxicological evaluation of cosmetic products, compared to traditional methods.
12 citations
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September 2022 in “Frontiers in Immunology” This study found that soluble CD83 (sCD83) accelerated chronic and hard-to-heal wound healing and improved inflammatory and pro-resolving cytokine profiles, suggesting potential for therapeutic use.
12 citations
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December 2021 in “Dermatology” This study found that trichoscopy can differentiate between dermatomyositis, systemic lupus erythematosus, and systemic sclerosis by identifying distinctive features and may help assess disease activity.
9 citations
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March 2022 in “Frontiers in Immunology” This review discusses the roles and mechanisms of tissue-resident regulatory T cells in immune regulation and tissue homeostasis, but reports no new experimental results.
9 citations
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June 2023 in “Cells” This review summarizes recent findings on how the dysregulated PI3K/Akt/mTOR pathway contributes to immune-mediated inflammatory skin disorders and discusses the potential of natural products, synthetic compounds, and biologic agents in their treatment. However, it emphasizes the need for further research to develop effective therapies.
8 citations
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July 2025 in “Gels” This review discusses how functionalized hydrogels can modulate the microbiome to aid tissue regeneration and infection control, highlighting their potential to deliver therapeutic agents effectively and support beneficial immune responses.
8 citations
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January 2025 in “JADA Foundational Science” This review discusses the state-of-the-art in photobiomodulation therapy for oral and dental applications and emphasizes the need for education, training, and addressing logistical issues for its routine use.