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This review discusses the diverse roles of PPARβ/δ in skin health and disease, including its involvement in skin wound healing and inflammatory skin conditions, without presenting new experimental results.

This article outlines methods to study the skin and its molecular traits, focusing on interpretation and techniques applicable to mouse models, including diverse assays and approaches like electron microscopy and large-scale lipid analyses.

In this study, researchers identified six unique genetic variants of a sheep gene, KRTAP19-3, with specific variants linked to changes in wool fibre traits, such as increased fibre diameter variability, suggesting these genetic differences affect wool characteristics in Chinese Tan sheep.

This review reports that transcriptional and epigenetic mechanisms in epithelial stem cells guide their fate in the epidermis and hair follicles, crucial for skin homeostasis, but disruptions can lead to disease.

This review discusses the role of corticotropin-releasing hormone in human skin, focusing on its regulation, receptors, and functions, and highlights parallels with the hypothalamo-pituitary-adrenal axis; it reports no new research findings.

This study found that differentiated cells of the corneal epithelium can be converted to hair and interfollicular epidermis through a multistep process involving dermal developmental signals.

This review discusses the plasticity of stem cell populations and their ability to switch between functions for tissue homeostasis and regeneration, emphasizing environmental and hormonal influences, and reports no new results.

This review discusses the molecular and functional aspects of the nude gene in skin biology, providing insights into its role and evolutionary development, but reports no new results.

This study found that mice lacking alkaline ceramidase 1 with elevated skin ceramide levels showed disrupted skin homeostasis, including altered hair follicle structures, increased water loss, and a hypermetabolism phenotype.

This study found that impaired TCF/Lef1 signaling in mice leads to significant skin barrier defects due to altered lipid metabolism and epidermal differentiation.

This study reviews the complex keratinization process in the epidermis, detailing how various factors regulate keratinocyte differentiation and emphasizing the importance of understanding this process for the pathogenesis of skin disorders like ichthyoses and psoriasis.

This paper reviews recent findings on epidermal development and stem cell regulation, listing key studies that contribute to understanding the molecular pathways involved in skin morphogenesis without reporting new experimental results.

This study demonstrates that PAD1 and PAD3 are involved in hair follicle differentiation, while PAD1 and PAD2 may play a role in the physiology of sweat glands and arrector pili muscles.

The researchers reported that stress-induced keratins in human skin are expressed at lower levels than those in healthy skin and are co-regulated with genes involved in differentiation, inflammation, and immunity, rather than replacing keratins of normal differentiation or indicating cell proliferation.

This review describes how recent discoveries in genetic defects and alternative pathways in androgen biosynthesis are reshaping our understanding of male sexual differentiation, but it presents no new clinical findings.

This study found that manipulating prolactin levels in New Zealand Wiltshire sheep induces wool follicle growth cycles, revealing gene expression changes that suggest roles for specific genes in follicle function.

This study found that treating skin wounds with a combination of epidermis-derived epithelial-like stem/progenitor cells and platelet-rich plasma improved tissue repair and increased vascularization and elastin content compared to platelet-rich plasma alone.

This study found that MYC and FGF pathways are crucial for hair cell regeneration in chick and zebrafish models, suggesting potential targets for promoting hair cell regeneration in mammals.

The researchers concluded that their new reconstructed human epidermis model from plucked hair follicle-derived keratinocytes offers a safer and simpler alternative to traditional skin-derived models for studying epidermal function.

This study found that exposure to 12-O-tetradecanoyl-phorbol-13-acetate in mouse skin caused changes in claudin expression and localization, indicating disruption and eventual recovery of the epidermal barrier.

This study successfully established Tsc2-deficient embryonic stem cells from Eker rats and found these cells have distinct gene expression compared to non-mutant cells, which could help identify new therapeutic targets for TSC-related pathogenesis.

The study found that aging in hair follicle stem cells leads to hair follicle miniaturization and eventual hair loss in both wild-type mice and humans by proteolyzing type XVII collagen.

This review examines the complex mechanisms that regulate skin stem cell development, activation, and differentiation, emphasizing the molecular signaling pathways that influence their fate and contribute to skin homeostasis.

This research detailed a single-cell atlas showing dynamic hair follicle stem cell states associated with the hair cycle during aging in mice, highlighting differences in chromatin landscape linked to stem cell differentiation and quiescence, and providing a foundation for future exploration of aging reversal.

This review discusses advancements and challenges in laboratory-based tissue-expansion and transplantation techniques for facial wound healing, noting potential for stem cell therapies but highlighting the ongoing absence of skin features like hair follicles in cultured grafts.

This study investigated the molecular mechanisms of hair follicle morphogenesis in Ordos fine-wool sheep, identifying differential genes related to primary and secondary hair follicles, and providing important insights for improving wool quality and breeding strategies.

This review discussed the potential of induced pluripotent stem cells (iPSCs) for hair follicle regeneration, covering current approaches and challenges, iPSC differentiation, and their possible future clinical applications in hair restoration.

This study found that loss of the DNA methyltransferase Dnmt3a, but not Dnmt3b, increased carcinogen-induced squamous tumors in murine epidermis, with combined deletion leading to more aggressive and metastatic carcinomas.

The research found that while Dnmt3a and Dnmt3b are not necessary for skin homeostasis in mice, the loss of Dnmt3a increases squamous tumor formation from carcinogens, and combined deletion of both results in more aggressive and metastatic tumors.

This study reports that in mice, CaR plays a critical role in sensing the epidermal Ca2+ gradient, influencing keratinocyte differentiation, and affecting epidermal development.