January 2024 in “Frontiers in endocrinology” This study found that genetic variants linked to hypothyroidism significantly increased the risk of developing alopecia areata, suggesting a causative connection between the two conditions.
October 2023 in “Oncotarget” In this study using live mice, researchers observed that during hair follicle regression, apoptosis in basal cells may propagate by triggering neighboring cells, potentially regulated by a gradient of pro-survival signals from stem cells, and proposed a testable mechanism to further explore this process.
In this study, Smad4 deletion in satellite cells hindered skeletal muscle regeneration in adult mice and did not enhance regeneration in aged mice, indicating Smad4's crucial role in muscle repair.
This study found that Smad4 is crucial for satellite cell amplification during skeletal muscle regeneration, with aged cells exhibiting less Smad4 and reduced regenerative capability in mice.
December 2017 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings” This article reviews the role of the National Alopecia Areata Foundation in promoting research and collaboration to find treatments or a cure for alopecia areata and reports no clinical results.
1 citations
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December 2022 in “Frontiers in Immunology” This review summarizes recent findings about the multi-site differentiation of tissue regulatory T cells, emphasizing the pivotal role of epigenetic remodeling, but it reports no new clinical results.
February 2024 in “Brain research bulletin” This study observed that inhibiting androgenic activity during early postnatal development significantly decreased body weight in female rats by day 90, while affecting food intake and fat distribution in both sexes based on the inhibited testosterone metabolic pathway.
3 citations
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July 2024 in “Cell Proliferation” In this study, a wound-induced skin fibrosis model in mice revealed that TGFβ signaling plays a pivotal role in maintaining fibrogenic characteristics in dermal adipocyte progenitors, which could inform new therapeutic approaches for fibrotic skin conditions such as scleroderma.
22 citations
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August 2020 in “Cells” This review discusses the role of TGM3 in skin and hair follicle biology, human tumor pathology, and genetic abnormalities, and reports no novel results; the authors highlight its potential as a cancer diagnostic biomarker.
19 citations
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May 2018 in “Molecular Medicine Reports” This study found that miR-339-5p negatively regulates loureirin A-induced differentiation of hair follicle stem cells, potentially impacting skin repair and regeneration by inhibiting the Wnt/β-catenin signaling pathway.
3 citations
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July 2025 in “Gels” This review explores how recombinant protein hydrogels, employing molecular engineering and crosslinking strategies, offer advanced applications in regenerative medicine by mimicking extracellular matrix dynamics and providing enhanced mechanical, environmental, and biological properties.
12 citations
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April 2022 in “Frontiers in Cell and Developmental Biology” This study found that stabilizing β-catenin in a specific mouse model led to temporarily increased hair density but ultimately accelerated hair follicle aging and hair thinning.
47 citations
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August 2024 in “Science Advances” This study introduces a new biomimetic double wound mask designed to promote scarless healing by coordinating multiple biological pathways and providing enhanced protection and nourishment to wounds.
11 citations
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June 2019 in “Tissue & Cell” This study indicates that COL17A1 plays a crucial role in the differentiation process of hair-follicle-associated pluripotent stem cells.
5 citations
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August 2021 in “Frontiers in Cell and Developmental Biology” This study found that DHEA along with osteogenic induction medium significantly promotes the osteogenic differentiation and proliferation of human bone marrow mesenchymal stem cells from older individuals.
1 citations
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September 2025 in “International Journal of Molecular Sciences” This study found that primary stem cells from concentrated growth factor can differentiate into adipogenic, endothelial, and neuronal lineages in vitro, suggesting potential for use in regenerative therapies.
67 citations
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December 1990 in “The journal of cell biology/The Journal of cell biology” This study identified two evolutionarily conserved ultra-high-sulfur keratin proteins in human and sheep hair follicles, which are specifically expressed in the hair cuticle during the late stages of fiber development.
13 citations
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June 2014 in “Molecular therapy” This study found that a lentiviral array of reporters can identify lineage-specific promoters and pathways in mesenchymal stem cell differentiation, aiding in the prediction of signaling pathway effects.
47 citations
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July 2023 in “Nature Genetics” 409 citations
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May 1991 in “Genes & Development” This study observed that overexpression of TGF-alpha in transgenic mice led to thicker epidermis and stunted hair growth, particularly in regions with normally thick skin and low hair density.
16 citations
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April 2024 in “Proceedings of the National Academy of Sciences” This study found that selectively targeting HDAC4 and HDAC7 in mice can reduce Th17 cell-mediated intestinal inflammation, suggesting a potential treatment approach for Th17-related inflammatory diseases like ulcerative colitis.
This study provides genomic and epigenomic insights into the white wax scale insect, highlighting high methylation levels and differential hormone profiles linked to its sexual dimorphism and developmental differences.
2 citations
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January 2023 in “BMC plant biology” This study found that root hair length and density in rice are controlled by distinct genomic regions, with 18 regions identified but no overlap between the traits.
7 citations
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March 2021 in “Molecular Medicine Reports” This study demonstrated that culturing high-passage dermal papilla cells with specific supplemented conditioned media may preserve their hair-inducing abilities, suggesting potential for reconstructing new hair follicles in vivo.
61 citations
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February 1997 in “Differentiation” Hair differentiation starts earlier than thought, involving multiple type-II keratins.
23 citations
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January 1986 This review discusses the chemical stability of protein envelopes found in the epidermis and other stratified squamous epithelia, but reports no new clinical results.
1 citations
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September 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that miR-148a plays a significant role in regulating skin homeostasis and hair follicle cycling, influencing stem cell activity and development in mice.
January 2012 in “DigtalCommons @ Texas Medical Center Library (Texas Medical Center)” This study found that Stat3 deletion in certain skin cells led to increased differentiation and altered stem cell behavior, suggesting its significant role in skin tumor development and keratinocyte migration.
252 citations
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March 1998 in “Developmental dynamics” This study suggests that fibroblast growth factors FGF-4, FGF-8, and FGF-9 may play redundant roles as signals in epithelial-mesenchymal interactions during multiple stages of tooth development in mice.
21 citations
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September 2010 in “Cancer Prevention Research” This study suggests that IGFBP-2 may play a role in basal cell carcinoma development by mediating epidermal progenitor cell expansion in hair follicles with activated Shh signaling.