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This review examines the complex mechanisms that regulate skin stem cell development, activation, and differentiation, emphasizing the molecular signaling pathways that influence their fate and contribute to skin homeostasis.

This study found that administering minoxidil and PGE₂ to pregnant mice with 22q11.2 deletion syndrome models corrected multiple developmental anomalies, including thymus growth and parathyroid positioning, by targeting prenatal mesenchymal differentiation.

This systematic review identified robust biomarkers associated with hidradenitis suppurativa and confirmed potential drugs for repurposing, highlighting key pathogenetic pathways and their links to comorbid disorders.

This study found that topical rebamipide, originally a gastric ulcer medication, can activate hair follicle stem cells and promote hair regeneration by modulating dermal adipocyte metabolism, with potential targeting of the prostaglandin E receptor EP4.

In this review, researchers examined the molecular diversity and expression patterns of major skin appendage proteins, like keratins and EDC proteins, in tetrapods, highlighting recent findings in reptiles and birds and identifying knowledge gaps for future research.

This study found that Neuregulin3 can influence the development and differentiation of mammary glands and epidermal features in mice, potentially by inducing c-Myc and altering cell proliferation and adhesion.

In this study, researchers used transcriptomics and modeling to uncover previously unknown cell populations and marker genes in developing hair follicles, providing insights into early cell fate establishment and offering tools for further research on skin appendages.

This review discusses the role of fibroblasts in treating diabetic complications and wound healing, highlighting their potential as immunomodulatory factors but provides no new clinical results.

This study demonstrates a method using intravital imaging to observe sensory hair-cell development and regeneration in zebrafish, which may facilitate assays for drug discovery related to aural function preservation.

This review summarizes recent research on the molecular properties and functions of L-PGDS and PGD2, but reports no new findings, highlighting their pathophysiological roles and guiding future studies.

This study identified 12 potential candidate biomarkers associated with hair loss by analyzing the differential expression of genes, suggesting possible therapeutic targets for alopecia.

This review discusses the role of stem cells and tissue engineering in regeneration and transplantation, emphasizing the need for advanced technologies to improve treatments for injuries and disabilities, but reports no new results.

This systematic review synthesizes evidence from the past 20 years to highlight the potential of exosome-based therapies from stem cells and plants in improving cutaneous repair, skin aging, and challenging dermatological conditions through mechanisms like immunomodulation and collagen remodeling.

This study examined the cytodifferentiation stage of hair follicle development in cashmere goats, identifying nine cell populations and key regulatory pathways, including transcription factors and keratin genes, that may influence fiber quality and inform breeding strategies.

In this study, chick embryo extract enhanced neuronal differentiation and trophic factor expression in rat hair follicle stem cells, suggesting potential improvements for stem cell therapies in neurodegenerative diseases.

This research highlights that various environmental pollutants, including particulate matter, tobacco smoke, and heavy metals, can significantly affect hair follicle health, linking them to conditions like alopecia areata and androgenetic alopecia, underscoring the need for further study in this area.

This study reported that exosomes derived from human amniotic mesenchymal stem cells (hAMSC-exo) accelerated hair growth in androgenetic alopecia mice by enhancing signals between hair follicle cells and improving cellular environments, particularly protecting against dihydrotestosterone-induced damage via Wnt/β-catenin signaling.

This review discusses the regulatory roles of type 2 alarmin cytokines in skin immunity, focusing on their implications in host defense, chronic inflammation, and cancer, but reports no new clinical results.

This paper explores the complex immune processes and cellular diversity that enable the skin to heal and resist invasion, and highlights its potential as a model for studying regeneration.

Monilethrix involves multiple genes affecting hair structure, including DSG4 mutations.

This review discusses melanocyte development, emphasizing the plasticity of melanoblasts and the role of both intrinsic and extracellular signals in their differentiation and migration, with no new clinical results reported.

This article discusses the diagnostic complexities of PCOS and emphasizes the importance of differentiating between polycystic ovaries and polycystic ovary syndrome; it presents no new experimental results.

This study validated a protocol for inducing surface ectoderm differentiation from human induced pluripotent stem cells and highlighted the role of TGFβ signaling pathways in this process.

This study suggests that UMPP activation is a key signaling pathway in differentiating primary and secondary hair follicles in cashmere goats.

This study reports that X chromosomes often show greater differentiation between human populations than autosomes, likely due to a mix of demography and selection pressures.

This article reviews potential mechanisms by which Finasteride might enhance mesenchymal stem cell viability and differentiation post-transplant, suggesting a supportive role in myocardial infarction therapy, yet reports no clinical results.

This study found that the transcription factor p63 is crucial for horizontal basal cell differentiation in the olfactory epithelium, suggesting a p63-dependent mechanism activates reserve stem cells after injury.

This article reviews the role of epithelial-mesenchymal interactions in hair follicle morphogenesis and the hair cycle, suggesting potential paths for developing treatments for hair growth disorders but providing no new clinical findings.

This study reported that gain-of-function mutations in TRPV3 lead to hair loss in mice by disrupting inner root sheath keratinocyte differentiation, ultimately causing follicular keratinocyte stem cell exhaustion and permanent follicle disruption.

This study observed that 2.5% of patients with mycosis fungoides or Szary syndrome experienced alopecia, predominantly within skin lesions, with scalp metastases from other cancers also potentially causing hair loss, highlighting the diagnostic value of trichoscopy in differentiating alopecia types.