65 citations
,
April 2018 in “Oncotarget” This review discusses the potential carcinogenic effects of anabolic androgenic steroids, particularly regarding Leydig cell tumors, and highlights the need for preventive information campaigns due to associated health risks.
18 citations
,
June 2017 in “Oncotarget” This study found that digoxin treatment was significantly associated with anemia adverse reactions in patients with atrial fibrillation and heart failure, suggesting a need for caution in its clinical use.
8 citations
,
July 2016 in “Oncotarget” This study reports that actively proliferating Lgr5+ stem cells in hair follicles do not appear to drive tumor formation in experimental skin carcinogenesis.
7 citations
,
November 2016 in “Oncotarget” This study found that Lgr6+ stem cells in mice are not major initiators of UV- or chemically induced skin tumors.
12 citations
,
March 2011 in “Journal of pathology” In this study, activation of oncogenic K-ras in a mouse model caused the oral mucosa to rapidly progress from squamous hyperplasia to carcinoma within 14 days, demonstrating its acute sensitivity.
23 citations
,
December 2004 in “Differentiation” This article reviews the interaction between sex hormone pathways and morphogenesis-related signaling in epithelial organ development, using a chicken model to propose testable hypotheses, but reports no new clinical results.
23 citations
,
November 2018 in “Development, Growth & Differentiation” This review discusses the role of stem cell heterogeneity and compartmentalization within the epidermis and highlights their significance as niches for neighboring cells, without reporting new experimental results.
13 citations
,
December 2018 in “Development, Growth & Differentiation” This study found that male and female chicken feather morphology and color patterns can be extrinsically modified through molting and resetting the stem cell niche during regeneration.
57 citations
,
April 2009 in “Differentiation” This study demonstrates that SDF-1/CXCL12 and CXCR4 signaling play a crucial role in directing the migration and positioning of melanoblasts in mouse hair follicle formation.
39 citations
,
April 2011 in “Recent Patents on Drug Delivery & Formulation” This review discusses various applications of nanoemulsions in drug delivery and reports no new clinical results; it highlights the patents that cover these applications.
13 citations
,
February 2004 in “Clinical and Experimental Ophthalmology” This report describes the clinical and histopathological features of lipoid proteinosis in a brother and sister with lid lesions, highlighting the importance of recognizing such lesions for diagnosis.
January 2026 in “Microsystems & Nanoengineering” This study analyzed 853 articles to reveal that research on silica-based nanobiomaterials in regenerative medicine has rapidly increased, with distinct regional differences in impact and emerging focus areas in drug delivery and wound healing.
February 2021 in “PARIPEX INDIAN JOURNAL OF RESEARCH” This study found that women with PCOS had a higher prevalence of hypothyroidism compared to those without PCOS, especially among the obese PCOS subgroup.
July 2021 in “Medical journal, Armed Forces India” This study reported that using platelet-rich plasma as an intraoperative holding solution significantly improved hair density and follicular growth in hair restoration surgery for androgenetic alopecia.
October 2024 in “International Journal of Pharmaceutical Sciences Review and Research” This study reviewed existing literature on Androgenetic Alopecia treatments, finding that minoxidil promotes hair growth but can cause side effects due to its traditional formulations. Novel delivery systems like film-forming sprays may reduce these side effects and enhance efficacy.
April 2024 in “Journal of cosmetic dermatology” This article discusses the development of liquid platelet-rich fibrin as a potential improvement over platelet-rich plasma for treating androgenetic alopecia and reports no new clinical results.
22 citations
,
April 2021 in “Human Cell” MicroRNAs may help diagnose and treat hair loss disorders.
January 2025 in “International Journal of Applied and Basic Medical Research” In this case report, a 40-year-old woman with folliculitis decalvans exhibits symptoms like itchy papules and patchy hair loss, illustrating the importance of distinguishing this condition from similar scarring alopecias for appropriate treatment.
76 citations
,
June 2018 in “EMBO Reports” This study demonstrates that YAP and TAZ are essential for initiating basal and squamous cell carcinomas in mice, and suggests targeting these pathways could be beneficial for treating skin cancers.
5 citations
,
February 2015 in “Journal of Comparative Pathology” This study suggests that high proliferative activity and peripheral invasion are key indicators of malignancy in canine sebaceous gland tumours. It also reports a higher incidence of circumanal gland and testicular tumours, indicating a possible androgen-related pathway in tumour development.
February 2024 in “Skin health and disease” This review reports that exosomes show potential in regenerative and cosmetic dermatology for applications like wound healing and hair loss mitigation, but their clinical use is currently limited by high costs, complex processing, and sparse clinical evidence.
9 citations
,
August 2017 in “Journal of comparative pathology” This study suggests that uncontrolled embryonic trichogenesis may play a role in the development of trichoblastoma in rabbits.
471 citations
,
October 2012 in “Cellular and Molecular Life Sciences” This review discusses the roles of key developmental signaling pathways in mammalian skin repair compared to skin development, and suggests these insights could lead to better wound healing therapies, but it reports no new findings.
234 citations
,
December 1996 in “Journal of The American Academy of Dermatology” The authors concluded that chronic telogen effluvium in middle-aged women presents distinct clinical and histological features that differ from androgenetic alopecia and acute telogen effluvium.
52 citations
,
January 2005 in “International journal of experimental pathology” This study suggests that melatonin may have a radioprotective role against X-ray-induced skin damage in rats, as evidenced by milder injury markers in pretreated animals.
29 citations
,
August 2017 in “Skin appendage disorders” This study found that IGF-1 likely plays a crucial role in regulating hair growth and alopecia, with balding scalp follicles secreting less IGF-1 than nonbalding counterparts.
25 citations
,
January 2014 in “Annals of Dermatology” Sfrp2 increases during hair follicle catagen phase and slows keratinocyte growth.
8 citations
,
January 2007 in “International journal of experimental pathology” This study observed that hairless HRS/J mice were resistant to Bacillus anthracis infection at the skin's surface, suggesting resistance may be due to increased dermal neutrophils rather than non-functional hair follicles.
5 citations
,
September 2010 in “Cancer Prevention Research” This perspective discusses Villani et al.'s findings on the role of the IGF regulatory protein Igfbp2 in basal cell carcinogenesis and highlights potential therapeutic and preventive targets, while raising questions about the cell of origin.
2 citations
,
May 2017 in “InTech eBooks” This review discusses the regenerative potential of hair follicle stem cell populations and current approaches to reconstructing folliculogenesis for alopecia therapy, but reports no new clinical results.