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The hypothesis suggests that PCOS may start early in life due to genetic and environmental factors, influencing future reproductive and metabolic problems.

Obesity affects skin health, causing conditions like acanthosis nigricans and may require different treatment approaches.

Testosterone is important for men's sexual function, may help some women's sexual desire, while other hormones and neurotransmitters also play complex roles in sexual behavior.

The Rotterdam Study updated findings on elderly health, focusing on heart disease, genetics, lifestyle effects, and disease understanding.

Human skin can make serotonin and melatonin, which help protect and maintain it.

Metformin helps with menstrual cycles and insulin levels in PCOS but is less effective for hair growth, diabetes prevention, and weight loss, and may improve fertility and reduce diabetes risk.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

Some drugs can cause rare but potentially deadly skin reactions, and early treatment and avoiding the drug again are key.

The document concludes that insulin resistance is key in PCOS development and early treatment is crucial to prevent complications.

Insulin resistance is a key factor in polycystic ovary syndrome, but genetics may also contribute.

The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

Tofacitinib is effective and safe for severe hair loss, but full regrowth is less likely after 10 years of hair loss.

Fat cells help recruit healing cells and build skin structure during wound healing.

The Rotterdam Study aims to understand various diseases in older adults.

Guidelines suggest various treatments for alopecia areata, but leaving it untreated is also an option as 80% cases may recover on their own.

The guidelines suggest a detailed approach to diagnosing and treating lupus, with a focus on regular check-ups, personalized medicine, and a range of drug options for different cases.

Calcium affects where root hairs grow, but other unknown factors determine their growth direction.

Male and female bodies respond differently to stress, influenced by hormones and development stages, with implications for stress-related diseases.

High levels of male hormones, insulin resistance, and obesity are closely linked and worsen polycystic ovary syndrome, but more research is needed to improve treatments.

Most women with excess hair growth have an underlying hormonal issue, often treated with medication and hair removal methods.

New effective scar treatments are urgently needed due to the current options' limited success.

Early development of hair, teeth, and glands involves specific signaling pathways and cellular interactions.

Accurate diagnosis and effective oral treatment are key to managing tinea capitis and preventing its spread.

Methotrexate treats various disorders by inhibiting DNA synthesis, but careful monitoring is needed to avoid toxicity and manage side effects.

Stem cell self-renewal is complex and needs more research for full understanding.

Skin aging is due to impaired stem cell mobilization or fewer responsive stem cells.

Male hormones affect COVID-19 severity and certain drugs targeting these hormones could help reduce the risk.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.

Fat cells in the skin help start healing and form important repair cells after injury.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.