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240-270 / 417 resultsresearch Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives
Natural small molecules can help treat diseases by activating or inhibiting the Wnt pathway.
![Nanostructured Drug Delivery Systems for Targeting 5-α-Reductase Inhibitors to the Hair Follicle](/images/research/fb498620-0cf8-4866-b921-3ce6be265f0f/small/5568.jpg)
research Nanostructured Drug Delivery Systems for Targeting 5-α-Reductase Inhibitors to the Hair Follicle
Nanostructured delivery systems could potentially improve hair loss treatment by targeting drugs to hair follicles, reducing side effects and dosage, but the best size, charge, and materials for these systems need further investigation.
research Pathogenesis of Alopecia Areata and Vitiligo: Commonalities and Differences
Alopecia areata and vitiligo share immune system dysfunction but differ in specific immune responses and affected areas.
![Changes in the hair growth cycle in women with non-scarring alopecia](/images/research/e3d42948-4624-4430-b022-2cc34afa0173/small/17845.jpg)
research Changes in the hair growth cycle in women with non-scarring alopecia
Certain growth factors affect hair loss in women and could be targeted for treatment.
![Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors](/images/research/9043efa5-811d-44c6-a24e-a03a6a6cf6ac/small/26801.jpg)
research Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors
Collagen from tilapia scales may improve hair and skin health by reducing stress and inflammation and encouraging hair growth.
research Hormonal and Genetic Etiology of Male Androgenetic Alopecia
![An appraisal of laboratory models of androgenetic alopecia: A systematic review](/images/research/26da0baa-b4d7-4602-b7be-90e83dd993b8/small/5154.jpg)
research An appraisal of laboratory models of androgenetic alopecia: A systematic review
Better hair loss models needed for research.
![T-cell “induced-self” MHC class I/peptide complexes may enable “de novo” tolerance induction to neo-antigens occurring outside of the thymus](/images/research/4786b405-c44d-4679-ab53-323b21641dea/small/35821.jpg)
research T-cell “induced-self” MHC class I/peptide complexes may enable “de novo” tolerance induction to neo-antigens occurring outside of the thymus
Hair follicles may help teach the immune system to tolerate new self-antigens, but this can sometimes cause hair loss.
![Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage](/images/research/d9411813-4369-4dbd-8a53-4c6adcc8d42e/small/18944.jpg)
research Androgen Receptor Accelerates Premature Senescence of Human Dermal Papilla Cells in Association with DNA Damage
Androgen receptor signaling causes early aging of cells important for hair growth by damaging their DNA.
![Crosstalk between androgen and Wnt/β-catenin leads to changes of wool density in FGF5-knockout sheep](/images/research/81a4efff-ef82-4986-9af6-241a1aae4491/small/17465.jpg)
research Crosstalk between androgen and Wnt/β-catenin leads to changes of wool density in FGF5-knockout sheep
Blocking the FGF5 gene in sheep leads to more fine wool and active hair follicles due to changes in certain cell signaling pathways.
![Advances in Hair Diseases](/images/research/da956897-2c0f-4093-a15d-06ff5451cac7/small/22683.jpg)
research Advances in Hair Diseases
The review highlights the importance of stem cells in hair health and suggests new treatment strategies for hair loss conditions.
![Vitamin D metabolism and function in the skin](/images/research/172b1a16-ea94-4188-afca-920748cf89e0/small/36012.jpg)
research Vitamin D metabolism and function in the skin
Skin cells produce and activate vitamin D, which regulates skin functions and supports hair growth.
![Vitamin D and the skin: Physiology and pathophysiology](/images/research/cb56b7c9-a83e-4ccd-9d76-3d1fde0e58cc/small/36015.jpg)
research Vitamin D and the skin: Physiology and pathophysiology
Vitamin D and its receptor regulate skin functions like cell growth, immunity, hair cycle, and tumor prevention.
![Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration](/images/research/965189cd-31a5-493d-81c5-a55cacecc5db/small/13296.jpg)
research Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration
Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.
![Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review](/images/research/f380f6c2-ac4c-4b0f-be1e-e54220ffd65f/small/20877.jpg)
research Protective Role of Nutritional Plants Containing Flavonoids in Hair Follicle Disruption: A Review
Some plants with flavonoids may help treat hair loss and promote hair growth.
![Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia](/images/research/fb237c2c-5c29-4419-97ff-693bf2e857bf/small/5110.jpg)
research Dihydrotestosterone-induced hair regrowth inhibition by activating androgen receptor in C57BL6 mice simulates androgenetic alopecia
DHT stops hair regrowth in mice, similar to human hair loss.
![Characterization of Human Dermal Papilla Cells in Alginate Spheres](/images/research/c6235046-2f1f-45cb-8eac-952d2912a0c4/small/13553.jpg)
research Characterization of Human Dermal Papilla Cells in Alginate Spheres
Alginate spheres help maintain hair growth potential in human cells for hair loss treatment.
![Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes](/images/research/472b28a8-6485-4682-9079-1686d37a8e5a/small/17396.jpg)
research Knockdown of FOXA2 Impairs Hair-Inductive Activity of Cultured Human Follicular Keratinocytes
Reducing FOXA2 in skin cells lowers their ability to grow hair.
![Clinical Patterns of Hair Loss in Men](/images/research/b77a4ed3-ffc1-450b-afb1-db68835f28e9/small/17173.jpg)
research Clinical Patterns of Hair Loss in Men
The document concludes that more research is needed to understand hair loss in men and to find new treatments.
![Fibroblast heterogeneity: implications for human disease](/images/research/7cdf0ea5-e0cf-46e9-b61c-a9b319032217/small/20225.jpg)
research Fibroblast heterogeneity: implications for human disease
Different types of fibroblasts play various roles in diseases and healing, and more research on them could improve treatments.
![Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla](/images/research/450feeda-6149-4034-bc3a-179ae3c7f481/small/3004.jpg)
research Molecular basis of androgenetic alopecia: From androgen to paracrine mediators through dermal papilla
Male pattern baldness involves hormones and cell signals affecting hair growth.
![Regulation of hair follicle development by exosomes derived from dermal papilla cells](/images/research/7edc8c3d-66c0-4c24-9a80-0a5742e6cd19/small/17922.jpg)
research Regulation of hair follicle development by exosomes derived from dermal papilla cells
Exosomes from dermal papilla cells can help grow hair and might treat hair loss.
![KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin](/images/research/74da5aaf-c1cb-4308-b4ce-7cd976c43a37/small/33032.jpg)
research KGF and EGF signalling block hair follicle induction and promote interfollicular epidermal fate in developing mouse skin
EGF and KGF signalling prevent hair follicle formation and promote skin cell development in mice.
![Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness](/images/research/ed924df4-8bfb-4e7a-9bf1-e2fe9eddf220/small/30881.jpg)
research Meta-analysis identifies novel risk loci and yields systematic insights into the biology of male-pattern baldness
Researchers found 63 genes linked to male-pattern baldness, which could help in understanding its biology and developing new treatments.
![Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms](/images/research/c97807ab-bb36-4d99-8f86-4ae5b5ec486a/small/13762.jpg)
research Hair-Growth Potential of Ginseng and Its Major Metabolites: A Review on Its Molecular Mechanisms
Ginseng and its compounds may help hair growth and prevent hair loss, but more human trials are needed to confirm this.
![Androgens and hair loss](/images/research/7f45dfec-2d49-47ab-9dd8-d9789cbfcaa1/small/16358.jpg)
research Androgens and hair loss
The document concludes that hair transplantation and gene therapy may be important for future hair loss treatment.
![Genetics and other factors in the aetiology of female pattern hair loss](/images/research/d659df05-0d93-47c2-8915-3011befe486c/small/4053.jpg)
research Genetics and other factors in the aetiology of female pattern hair loss
Female pattern hair loss has unclear causes, possibly involving genetics, hormones, and environment, and needs better treatments.
![KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis](/images/research/7fee71c2-1eab-463f-8021-2ac18d04cf3d/small/11452.jpg)
research KY19382, a novel activator of Wnt/β‐catenin signalling, promotes hair regrowth and hair follicle neogenesis
KY19382 helps regrow hair and create new hair follicles.
![Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia](/images/research/01db698a-2f31-4ef3-a5a8-a15d43f8bfe2/small/4941.jpg)
research Comparative Evaluation of the Clinical Efficacy of PRP-Therapy, Minoxidil, and Their Combination with Immunohistochemical Study of the Dynamics of Cell Proliferation in the Treatment of Men with Androgenetic Alopecia
PRP therapy and minoxidil combo works best for male hair loss.