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180-210 / 417 resultsresearch Small Molecule Wnt Pathway Modulators from Natural Sources: History, State of the Art and Perspectives
Natural small molecules can help treat diseases by activating or inhibiting the Wnt pathway.
research Health Risks Associated with Long-Term Finasteride and Dutasteride Use: It’s Time to Sound the Alarm
![Acquired curved hair is caused by fusion of multiple hair matrix cells](/images/research/88c178b2-adfb-441e-8f94-2bac35928b64/small/26465.jpg)
research Acquired curved hair is caused by fusion of multiple hair matrix cells
Curved hair can develop when hair cells merge abnormally during growth.
![Millet seed oil activates β–catenin signaling and promotes hair growth](/images/research/77b6581a-3800-4ee1-92e5-64cae42da65a/small/16623.jpg)
research Millet seed oil activates β–catenin signaling and promotes hair growth
Millet seed oil may help hair grow by activating certain cell growth signals.
![Valproic acid promotes human hair growth in in vitro culture model](/images/research/5bafab82-c5fe-47f2-ab6a-17cabfe2fe1e/small/18961.jpg)
research Valproic acid promotes human hair growth in in vitro culture model
Valproic acid may help hair grow and could be a safe treatment for hair loss.
![miR-29a-5p Inhibits Prenatal Hair Placode Formation Through Targeting EDAR by ceRNA Regulatory Network](/images/research/fd7e29e9-c2b6-4834-bb25-51fe1a3d354e/small/19195.jpg)
research miR-29a-5p Inhibits Prenatal Hair Placode Formation Through Targeting EDAR by ceRNA Regulatory Network
miR-29a-5p prevents the formation of early hair structures by targeting a gene important for hair growth and is regulated by a complex network involving lncRNA627.1.
research MECHANISM OF ACTION OF AVICENNIA MARINA HEARTWOOD EXTRACT AND AVICEQUINONE C ON HUMAN DERMAL PAPILLA CELLS ISOLATED FROM ANDROGENIC ALOPECIA PATIENTS
Avicennia Marina extract and avicequinone C can reduce hair loss hormone production and increase hair growth factors, suggesting they could be used to treat androgenic alopecia.
![Effects of Allium hookeri Extracts on Hair-Inductive and Anti-Oxidative Properties in Human Dermal Papilla Cells](/images/research/d863cab2-9378-4e54-81b8-5bdcdba14f6a/small/16617.jpg)
research Effects of Allium hookeri Extracts on Hair-Inductive and Anti-Oxidative Properties in Human Dermal Papilla Cells
Allium hookeri extract may help promote hair growth and protect cells from damage.
![Transcriptome Dynamics Reveal Stage-specific and Melatonin-triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus](/images/research/ad482113-aeec-4551-bdbb-3858c899de49/small/34859.jpg)
research Transcriptome Dynamics Reveal Stage-specific and Melatonin-triggered Gene Expression Patterns During the Cashmere Growth Cycle in Capra Hircus
Melatonin can increase cashmere yield by altering gene expression and restarting the growth cycle early.
![Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During The Cashmere Growth Cycle in Capra Hircus](/images/research/7c9d9550-4445-4815-9843-fcf905dad9bb/small/30629.jpg)
research Transcriptome Dynamics Reveal Stage-Specific and Melatonin-Triggered Gene Expression Patterns During The Cashmere Growth Cycle in Capra Hircus
Melatonin affects certain genes and pathways involved in cashmere goat hair growth.
![The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin](/images/research/8178a713-1cdd-4e89-b4f2-dd2908777cbd/small/14340.jpg)
research The inductive effect of ginsenoside F2 on hair growth by altering the WNT signal pathway in telogen mouse skin
Ginsenoside F2 from ginseng may increase hair growth better than standard treatments by affecting cell growth signals.
![Roles of GasderminA3 in Catagen–Telogen Transition During Hair Cycling](/images/research/9244e306-b071-4ca2-b631-aaa955070f8d/small/19667.jpg)
research Roles of GasderminA3 in Catagen–Telogen Transition During Hair Cycling
GasderminA3 is important for normal hair cycle transitions by controlling Wnt signaling.
![Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration](/images/research/965189cd-31a5-493d-81c5-a55cacecc5db/small/13296.jpg)
research Functional complexity of hair follicle stem cell niche and therapeutic targeting of niche dysfunction for hair regeneration
Understanding how hair follicle stem cells work can help find new ways to prevent hair loss and promote hair growth.
![Functional hair follicle regeneration: an updated review](/images/research/62e6bdbe-5734-4ce3-a0fc-6ae62895fca5/small/5138.jpg)
research Functional hair follicle regeneration: an updated review
Hair follicle regeneration possible, more research needed.
research Pathogenesis of Alopecia Areata and Vitiligo: Commonalities and Differences
Alopecia areata and vitiligo share immune system dysfunction but differ in specific immune responses and affected areas.
![Panax ginseng extract antagonizes the effect of DKK-1-induced catagen-ike changes of hair follicles](/images/research/933a118c-f865-4433-b4a0-4c97a8d13278/small/18170.jpg)
research Panax ginseng extract antagonizes the effect of DKK-1-induced catagen-ike changes of hair follicles
Panax ginseng extract may help prevent hair loss caused by DKK-1.
![Spatial transcriptomics of a giant pilomatricoma](/images/research/04a393fd-4951-4368-b9bf-cb194e91bcb3/small/30282.jpg)
research Spatial transcriptomics of a giant pilomatricoma
The analysis of a large pilomatricoma revealed five distinct areas with different gene activity related to hair growth and tumor development.
research The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis
The study found that the protein Dkk4 helps regulate hair growth by controlling Wnt signaling in mice.
![A preliminary study of differentially expressed genes in expanded skin and normal skin: implications for adult skin regeneration](/images/research/1f11c7bd-b4c0-4372-8876-02572ea37e38/small/19877.jpg)
research A preliminary study of differentially expressed genes in expanded skin and normal skin: implications for adult skin regeneration
The study found that expanded skin regenerates similarly to normal skin, with 77 genes playing a role in the process.
![Signaling Involved in Hair Follicle Morphogenesis and Development](/images/research/c3fee2da-536b-43be-ae5f-ec7955b5d3e7/small/14302.jpg)
research Signaling Involved in Hair Follicle Morphogenesis and Development
The conclusion is that proper signaling is crucial for hair growth and development, and errors can lead to cancer or hair loss.
![In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos (Anser cygnoides)](/images/research/277b1019-3f08-4981-b370-2654cbcd3cfc/small/34147.jpg)
research In Ovo Injection of CHIR-99021 Promotes Feather Follicle Development via Modulating the Wnt Signaling Pathway and Transcriptome in Goose Embryos (Anser cygnoides)
Injecting CHIR-99021 into goose embryos improves feather growth by changing gene activity and energy processes.
![Developmental genetics of color pattern establishment in cats](/images/research/b58e6d5e-04f8-478f-b02c-e3b9661c44ee/small/30646.jpg)
research Developmental genetics of color pattern establishment in cats
Cat color patterns are determined early in development by gene expression and epidermal changes, with the Dickkopf 4 gene playing a crucial role.
![318 The Wnt-inhibitor Dkk4 is required for primary hair follicle induction and patterning](/images/research/729a54b0-f94f-46e3-9837-24ac25a9ea8b/small/17115.jpg)
research 318 The Wnt-inhibitor Dkk4 is required for primary hair follicle induction and patterning
Dkk4 protein is necessary for the proper development and arrangement of hair follicles.
![Inhibitory activities of Puerariae Flos against testosterone 5α-reductase and its hair growth promotion activities](/images/research/5202d4c5-d5a6-46cf-9f8b-48f288df9e00/small/14754.jpg)
research Inhibitory activities of Puerariae Flos against testosterone 5α-reductase and its hair growth promotion activities
Puerariae Flos extract may help treat hair loss by blocking a hair loss-related enzyme and promoting hair growth.
research MiR-199a-3p Regulates the PTPRF/β-Catenin Axis in Hair Follicle Development: Insights into the Pathogenic Mechanism of Alopecia Areata
miR-199a-3p controls hair growth and is linked to alopecia areata.
![Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells](/images/research/c78cb056-b796-4d96-92e6-d828756e17ca/small/17996.jpg)
research Prostaglandin D2-Mediated DP2 and AKT Signal Regulate the Activation of Androgen Receptors in Human Dermal Papilla Cells
PGD2 increases androgen receptor activity in hair cells, which could be targeted to treat hair loss.
![Telogen Effluvium, Diagnosis and Management: A Narrative Review](/images/research/f4a35a01-bda6-49b4-9f02-aa9cc876b18b/small/16693.jpg)
research Telogen Effluvium, Diagnosis and Management: A Narrative Review
Hair loss from Telogen Effluvium can be managed by treating the underlying cause and may improve with treatments like minoxidil.
![Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells](/images/research/125dcdef-97e9-48c8-8b85-ba290a3465d3/small/17399.jpg)
research Hair Growth Activity of Three Plants of the Polynesian Cosmetopoeia and Their Regulatory Effect on Dermal Papilla Cells
Extracts from three Polynesian plants were found to promote hair growth by affecting cell growth and gene expression related to hair.
![Induction of hair growth in hair follicle cells and organ cultures upon treatment with 30 kHz frequency inaudible sound via cell proliferation and antiapoptotic effects](/images/research/7d2c622c-3935-4e4a-a88d-3ef41b079f6d/small/5564.jpg)
research Induction of hair growth in hair follicle cells and organ cultures upon treatment with 30 kHz frequency inaudible sound via cell proliferation and antiapoptotic effects
Inaudible sound at 30 kHz can boost hair growth and decrease hair loss by promoting cell growth and reducing cell death in hair follicles.