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    Glossary Dickkopf-1

    inhibits hair follicle formation, contributing to hair loss

    Dickkopf-1 (DKK1) is a protein that plays a crucial role in regulating cell signaling pathways, particularly the Wnt signaling pathway, which is important for cell growth and development. In the context of hair biology, DKK1 is known to inhibit hair follicle formation and is associated with conditions like androgenetic alopecia (pattern baldness), where its elevated levels can lead to hair loss.

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    Research 30 of 549

    1. Dihydrotestosterone-Inducible Dickkopf 1 from Balding Dermal Papilla Cells Causes Apoptosis in Follicular Keratinocytes Journal of Investigative Dermatology · 2007 · 171 citations
    2. Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosteroneinduced dickkopf-1 expression in human hair dermal papilla cells BMB Reports · 2010 · 31 citations
    3. I‐Ascorbic acid 2‐phosphate represses the dihydrotestosterone‐induced dickkopf‐1 expression in human balding dermal papilla cells Experimental Dermatology · 2010 · 13 citations
    4. Assessment of tissue levels of dickkopf-1 in androgenetic alopecia and alopecia areata Journal of Cosmetic Dermatology · 2015 · 10 citations
    5. Dickkopf-1 Expression in Androgenetic Alopecia and Alopecia Areata in Male Patients American Journal of Dermatopathology · 2019 · 9 citations
    6. Ectodysplasin-A2 induces dickkopf 1 expression in human balding dermal papilla cells overexpressing the ectodysplasin A2 receptor Biochemical and Biophysical Research Communications · 2020 · 4 citations
    7. Attenuation of Dickkopf 1-Induced Hair Growth Inhibition in Cultured Human Hair Follicles by Tianeptine Annals of Dermatology · 2017 · 4 citations
    8. Preventable effect of L-threonate, an ascorbate metabolite, on androgen-driven balding via repression of dihydrotestosteroneinduced dickkopf-1 expression in human hair dermal papilla cells BMB Reports · 2010 · 2 citations
    9. Serum Dicckopf-1 Level in Patients of Cicatricial and Non- Cicatricial Alopecia Benha Journal of Applied Sciences · 2022
    10. The Wnt inhibitor, Dickkopf 4, is induced by canonical Wnt signaling during ectodermal appendage morphogenesis Developmental biology · 2007 · 96 citations
    11. Dickkopf-related Protein 2 Promotes Hair Growth by Upregulating the Wnt/β-catenin Signaling Pathway in Human Dermal Papilla Cells Annals of Dermatology · 2024 · 6 citations
    12. The Dickkopf Protein Family in Non-Neoplastic Disorders: Emerging Roles and Therapeutic Targeting Aging and Disease · 2026
    13. Panax ginseng extract antagonizes the effect of DKK-1-induced catagen-ike changes of hair follicles International Journal of Molecular Medicine · 2017 · 15 citations
    14. Effects of watercress extract fraction on R‐spondin 1‐mediated growth of human hair International Journal of Cosmetic Science · 2022 · 4 citations
    15. 1343 Efficacy of asymmetric siRNA targeting androgen receptor for the treatment of androgenetic alopecia Journal of Investigative Dermatology · 2023
    16. 1332 Janus kinase inhibitor increases hair growth by increasing beta-catenin activity in outer root sheath cells 2023
    17. 1365 Interest of Biotrinine®, a mix of Nasturtium officinale and Tropaeolum majus extracts, for chronic hair loss treatment 2018
    18. Canonical WNT signaling promotes mammary placode development and is essential for initiation of mammary gland morphogenesis Development · 2004 · 293 citations
    19. Dynamic Signals for Hair Follicle Development and Regeneration Stem Cells and Development · 2011 · 60 citations
    20. Androgens modify Wnt agonists/antagonists expression balance in dermal papilla cells preventing hair follicle stem cell differentiation in androgenetic alopecia Molecular and Cellular Endocrinology · 2016 · 47 citations
    21. Visible-to-Near IR Quantum Dot–Based Hypermulticolor High-Content Screening of Herbal Medicines for the Efficacy Monitoring of Hair Growth Promotion and Hair Loss Inhibition SLAS discovery · 2012 · 14 citations
    22. <i>Melandrium firmum</i>Extract Promotes Hair Growth by Modulating 5α-Reductase Activity and Gene Expression in C57BL/6J Mice Annals of Dermatology · 2019 · 2 citations
    23. Recent approaches of antibody therapeutics in androgenetic alopecia Frontiers in Pharmacology · 2024
    24. Acquired curved hair is caused by fusion of multiple hair matrix cells Journal of Dermatological Science · 2024
    25. AP collagen peptides improve hair growth and quality by promoting human hair cell proliferation and keratin synthesis Archives of Biological Sciences (Beograd) · 2024
    26. Platelet-Rich Plasma Contains High Concentrations of DKK1, A Potent Inhibitor of Wnt Signaling that Limits Bone Regeneration and Hair Growth Journal of orthopedics & bone disorders · 2023
    27. Hair Sciences: The hair cycle discussed with Dr. Gilliam Westgate Hair transplant forum international · 2009
    28. Role of Dermal Factors Involved in Regulating the Melanin and Melanogenesis of Mammalian Melanocytes in Normal and Abnormal Skin International journal of molecular sciences · 2024
    29. Therapeutic Potentiality of Celtis choseniana Nakai on Androgenic Alopecia through Repression of Androgen Action and Modulation of Wnt/β-catenin Signaling Natural product sciences · 2023
    30. Efficacy of Asymmetric siRNA Targeting Androgen Receptors for the Treatment of Androgenetic Alopecia Molecular Pharmaceutics · 2022