84 citations
,
February 1981 in “Journal of Endocrinology” This study found that epidermal growth factor decreased hair growth rate and altered hair characteristics in neonatal mice, with some effects persisting into subsequent hair generations.
76 citations
,
December 2006 in “Journal of Dermatological Science” This study observed that Japanese women experience diffuse central hair loss after age 40, characterized by reduced hair density and thicker hair ratio rather than vellus-like hairs.
70 citations
,
February 2017 in “Dermatologic Surgery” This study reports that plasma rich in growth factors appeared to improve hair follicle regeneration and patient satisfaction in individuals with androgenetic alopecia, though further trials are needed.
70 citations
,
June 2003 in “Journal of Investigative Dermatology Symposium Proceedings” This study reports that the TrichoScan method effectively measures hair growth parameters and detected significant improvements in hair counts and thickness in men with androgenetic alopecia after finasteride treatment.
69 citations
,
January 2015 in “Current problems in dermatology” This review discusses trichoscopy as a noninvasive, effective technique for diagnosing various hair loss conditions and monitoring treatment, highlighting its potential to reduce scalp biopsy necessity.
68 citations
,
May 1991 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” This study found that both cyproterone acetate and spironolactone effectively reduced hair diameter and plasma testosterone levels in hirsute women, with no significant differences between the two treatments.
66 citations
,
November 2011 in “Journal of The American Academy of Dermatology” This study concluded that a polarized-light handheld dermatoscope attached to a digital camera is a practical and useful tool for diagnosing different types of alopecia.
63 citations
,
March 2001 in “Fertility and Sterility” This study found that Diane 35 combined with finasteride led to a greater reduction in hirsutism scores over 12 months compared to Diane 35 alone.
59 citations
,
January 2003 in “Phytomedicine” This study found that a cream containing 2% Fennel extract reduced hair diameter in idiopathic hirsutism patients more effectively than a cream with 1% Fennel or a placebo.
53 citations
,
January 1985 in “Acta obstetricia et gynecologica Scandinavica” This study found that an 8-month treatment with a low-dose oral contraceptive significantly reduced testosterone levels and hair growth in women with polycystic ovary syndrome and hirsutism, with minimal side effects.
48 citations
,
February 2010 in “Molecular biology reports” This study found that KAP7.1 and KAP8.2 genes were significantly more expressed in secondary hair follicles than primary follicles, suggesting their role in regulating cashmere fiber diameter.
46 citations
,
January 2015 in “Journal of The American Academy of Dermatology” This study suggests that trichoscopic features, such as perifollicular erythema and cicatricial white patches, are independently associated with pruritus and the severity of frontal fibrosing alopecia.
46 citations
,
August 1990 in “The Journal of clinical endocrinology and metabolism/Journal of clinical endocrinology & metabolism” In this study, ketoconazole treatment improved acne in all women and reduced hirsutism in some, but it caused several side effects and requires careful monitoring.
46 citations
,
April 1971 in “American Journal of Clinical Nutrition” Lack of protein causes hair root damage, but it can be reversed by eating protein again.
45 citations
,
May 2018 in “Stem Cell Research & Therapy” In this study, patients receiving adipose-derived stromal vascular cell transplantation for alopecia areata experienced significant hair regeneration, increased growth, and improved hair quality after 3 and 6 months, indicating potential efficacy of this stem cell-based therapy for hair loss.
43 citations
,
July 2018 in “Journal of The European Academy of Dermatology and Venereology” This study found that a topical solution combining 0.25% finasteride with 3% minoxidil significantly improved hair growth, as measured by hair density, diameter, and global assessment, in men with androgenetic alopecia, compared to 3% minoxidil alone, over 24 weeks without systemic adverse effects reported.
43 citations
,
August 2013 in “Pediatric Dermatology” This review discusses the use of trichoscopy in diagnosing and managing pediatric hair and scalp disorders and reports no new experimental findings.
38 citations
,
December 2011 in “British Journal of Dermatology” This review discusses the influence of menopausal status on hair parameters in women without alopecia, finding significant differences in hair growth rate, percentage anagen, and hair diameter distributions, particularly in the frontal scalp.
38 citations
,
January 1997 in “Gynecological Endocrinology” This study found that both finasteride and flutamide effectively reduced hirsutism in women with polycystic ovary syndrome, decreasing the Ferriman-Gallwey score and hair diameter without significant side effects.
38 citations
,
October 1988 in “Clinics in Dermatology” This article reviews the historical development of understanding the hair growth cycle, particularly anagen, catagen, and telogen phases, and reports no new clinical findings.
37 citations
,
May 2016 in “JAAD case reports” This abstract describes monilethrix, an autosomal dominant genodermatosis with symptoms like hair fragility and keratosis pilaris, and does not report new experimental results.
36 citations
,
September 2018 in “American Journal of Clinical Dermatology” This study found that a topical combination of 0.25% finasteride and 3% minoxidil may increase hair diameter more effectively than 3% minoxidil alone in postmenopausal women with female pattern hair loss.
34 citations
,
August 1966 in “Experimental cell research” This study examined developing hair cortex with electron microscopy and found that keratin fibrils form between specific regions in hair follicles and aggregate into twisted cables.
33 citations
,
July 2007 in “Skin research and technology” The study found that the break force of human hair significantly depends on hair diameter and strain, but not on age, gender, use of hair dye, or drugs.
31 citations
,
December 2012 in “British Journal of Dermatology” This study found that as Korean women age, their hair density, diameter, tensile strength, and lustre decline, while grey hair ratio and certain sterol contents increase, suggesting unique ageing features compared to women in other countries.
31 citations
,
August 2001 in “PubMed” This study found that the TrichoScan method detected significant increases in hair counts and cumulative hair thickness in men after finasteride treatment, suggesting its potential for monitoring hair treatment responses.
30 citations
,
January 2015 in “Dermatology” This study found that 308-nm excimer laser therapy improved hair diameter in alopecia areata patients, as shown by photographic assessments and a side-by-side comparison with control patches.
30 citations
,
April 2009 in “Dermatologic Surgery” This study found that miniaturization of hair is present in some women with androgenetic alopecia, but diagnosis may also be based on differences in hair shaft diameter between scalp regions.
29 citations
,
March 2008 in “Dermatologic Surgery” This study developed a prototype device that suggests potential for diagnosing changes in hair quantity, diameter, and density, though formal clinical studies are needed to confirm these findings.
28 citations
,
December 2002 in “Der Hautarzt” TrichoScan accurately measures hair growth and loss, showing increased hair counts and thickness with treatment.