Search

everythingexperts & clinicslearnfaqsresearchcommunity

for

Search:↓

This study suggests that in rats, maternal hyperandrogenism and insulin resistance lead to activation of ferroptosis in the gravid uterus and placenta, mediated by different molecular and cellular mechanisms.

This study found that despite the presence of steroidogenesis inhibitors, CRPC tumor cells adapt to continue synthesizing androgens, suggesting a need for more effective androgen axis targeting.

This study indicates that insulin changes sex hormone levels in insulin-resistant women with polycystic ovary syndrome without affecting gonadotropin release, challenging the idea that hyperinsulinemia directly causes hyperandrogenism in PCO.

This study found that overexpression of AKR1C3 in prostate cancer cells redirected androgen metabolism towards testosterone production, which facilitated cell proliferation, potentially reducing the effectiveness of finasteride treatment.

This study found that in PCOS patients, a lower TT/DHT ratio is associated with regular menstruation, while higher ratios are linked to insulin resistance, suggesting its potential as a biomarker for metabolic severity in these patients.

This study found that untreated men with coeliac disease exhibited androgen resistance, potentially linked to sexual dysfunction, which improved as intestinal health improved, a pattern not observed in other chronic illnesses.

In this study of healthy men, low levels of testosterone and dihydrotestosterone were associated with higher body mass index, fat content, and insulin resistance, but their effects on lipid and glucose metabolism were similar in quality.

Hormones cause hair loss by affecting cell growth and weakening cell attraction.

This study found that combining fructose and DHT in rats successfully mimicked the clinical phenotypes of non-lean PCOS, providing a novel rodent model for this condition.

This article reviews the potential male equivalent of polycystic ovarian syndrome, focusing on hormonal alterations and premature androgenic alopecia, but reports no new clinical findings; the authors highlight the need for further studies on adrenal steroids and other factors.

This study reviewed recent scientific evidence on the neuroendocrine and metabolic impacts of chronic use of 5-alpha reductase inhibitors, detailing its association with sexual dysfunction, mood disorders, insulin resistance, and other metabolic disorders, suggesting persistent biopsycho-social risks beyond transient side effects in users.

This study found that in female dogs, exposure to free fatty acids increased androgen production, suggesting a potential link to factors characteristic of polycystic ovary syndrome.

This review discusses the androgen-dependent and genetic factors of androgenetic alopecia, highlighting differences in its manifestation between men and women, and reports no new clinical results.

This review discusses potential strategies for rejuvenating miniaturizing hair follicles in androgenic alopecia but reports no new clinical results; it explores the idea of using DHT-resistant follicle preservation for long-term hair maintenance.

This source reports that while creatine supplementation is popular for improving muscle mass and performance, questions about its efficacy and safety persist. An expert team is reviewing literature to address concerns like water retention, renal effects, and its benefits across different populations and uses.

Early surgery reduces seizure risk in drug-resistant epilepsy; testosterone to DHT conversion doesn't affect muscle anabolism; veterans with PTSD likely to have riskier opioid use; bevacizumab helps in hereditary bleeding disorder.

This study suggests that the adrenal gland may contribute to prostate cancer treatment resistance and indicates potential steroid production or dependency in ovarian cancer.

This study found that gonadal steroid hormones influence alopecia areata in C3H/HeJ mice, with estradiol promoting progression and dihydrotestosterone conferring resistance to disease onset.

In this study, creatine supplementation over 12 weeks showed no effect on androgen levels or hair follicle health in healthy young males, challenging the belief that creatine causes hair loss.

This study found that supraphysiological doses of testosterone alter endothelial relaxation pathways in hypertensive rats, with varied contributions from nitric oxide, prostanoids, and endothelium-derived hyperpolarizing factors, influenced by estrogen and dihydrotestosterone levels.

This review discusses alternative androgen pathways, including the "backdoor" pathway and pathways to 11-oxygenated steroids, and reports no new clinical results; the authors aim to clarify these concepts for better patient treatment.

This review discusses the production, role, and measurement of dihydrotestosterone (DHT) in various disorders of sexual development but does not report new clinical results.

This study found that 2-methoxyestradiol induces apoptosis in human prostate cancer cells by activating p53 through a pathway dependent on p38/JNK-mediated NFkappaB/AP-1 activation, with JNK-dependent Bcl-2 phosphorylation also playing a critical role.

This review discusses the role of anti-androgen therapies in cancer and other diseases and reports no new clinical results, highlighting both old and new generations of anti-androgens.

This study found that MENT is 10 times more potent than testosterone in suppressing gonadotropins and contributing to anabolism in monkeys, with a potentially wider therapeutic index for human androgen replacement and male contraception.

This review summarizes the structural and chemical characteristics of current and novel antiandrogenic drugs but reports no new clinical findings.

The document explains how certain drugs block hormones to treat cancers like breast and prostate cancer.

This review discusses genetic factors and associated diseases linked to androgenetic alopecia but reports no new clinical findings.

Different treatments for skin conditions were found to be effective and generally safe, with biologics recommended as the first choice for generalized pustular psoriasis.

This study found that applying both dehydrothermal treatment and carbodiimide crosslinking improved the mechanical properties of porcine acellular dermal matrix scaffolds without added cytotoxicity, suggesting potential applications in tissue engineering.