4 citations
,
February 2021 in “Nano select” This review discusses the role and therapeutic potential of mesenchymal cell-derived exosomes in organ development and disease treatment, highlighting their application in cell-free therapeutic strategies and current challenges faced in their use.
2 citations
,
January 2011 in “Andrologia” This study concluded that 16β-methyl-17α-benzoyloxypregnen-4-en-3,20-dione may be a promising treatment for androgen-dependent diseases and epilepsy due to its antioxidant effects and impact on GABAergic and serotonergic metabolism in rats.
1 citations
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June 2021 in “Computer methods and programs in biomedicine” This study found that children with cancer showed more deviation from typical facial morphology compared to healthy controls, although the differences were not enough to distinguish patients from controls based on facial asymmetry alone.
This study found that neonatal administration of finasteride reduced sensitivity to alcohol's motor-stimulating effects and increased preference for novelty and initial alcohol consumption in rats, suggesting a role in alcohol vulnerability.
March 1997 in “The American Journal of Cosmetic Surgery” A new hair transplant method showed promising results and a study found how deep a CO₂ laser can penetrate skin.
October 1988 in “Pediatric research” In this study, researchers observed that the sequence of maturity markers in normal boys showed specific time lags, with some markers appearing before and others after spermarche.
147 citations
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November 2020 in “International Journal of Molecular Sciences” This review discusses the immune roles of keratinocytes in wound healing and chronic wound inflammation, emphasizing their potential impact on chronic wound pathology and highlighting areas for future research.
80 citations
,
April 2011 in “Plant physiology” This study suggests that the GPX-PDE1 and GPX-PDE2 genes in white lupin enhance root hair development and contribute to Pi limitation acclimation by facilitating glycerophosphodiester degradation.
77 citations
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January 2015 in “International Journal of Biological Macromolecules” This study developed minoxidil sulphate-loaded chitosan nanoparticles that doubled drug delivery to hair follicles in vitro compared to a control solution, suggesting potential for improved alopecia treatment.
69 citations
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April 2019 in “Biomedicines” This study found that hair thickness and density increased after treatment with human follicle mesenchymal stem cells and platelet rich plasma, associated with enhanced Wnt signaling and platelet derived growth factors.
66 citations
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April 2017 in “International Journal of Andrology” This study found that 5α-reductase inhibitors significantly increase the risk of erectile dysfunction and hypoactive sexual desire in men with benign prostatic hyperplasia, compared to placebo.
33 citations
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January 2018 in “The International Journal of Developmental Biology” This review discusses the dual role of cellular senescence in ageing and tissue repair and suggests potential therapeutic applications, with no new experimental results reported.
32 citations
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March 2013 in “Journal of Pharmaceutical Sciences” This study observed that iontophoresis significantly improved the delivery of minoxidil sulfate to hair follicles compared to passive methods, suggesting potential benefits for alopecia treatment.
28 citations
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November 2017 in “Skin appendage disorders” This paper proposes a systematic approach to evaluating scalp itch using the SCALLP acronym and highlights the importance of classifying cases based on the presence of dermatological lesions and hair loss, but it reports no new clinical findings.
27 citations
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August 2018 in “Therapeutic Delivery” In this study, researchers reviewed recent advances in using nanoencapsulation technology to improve the pharmacological treatment of alopecia, suggesting its potential to enhance drug delivery and reduce adverse effects compared to conventional methods.
22 citations
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October 2020 in “Anais Brasileiros de Dermatologia” This consensus concluded that oral isotretinoin is highly effective for treating acne and some off-label conditions, with common adverse events being manageable and rare serious risks not contraindicating use.
21 citations
,
January 2021 in “Journal of infection and chemotherapy” This study observed that male sex, diabetes mellitus, and high maximum C-reactive protein levels during the acute phase of COVID-19 were linked to elevated anti-SARS-CoV-2 antibody levels.
21 citations
,
November 2022 in “Frontiers in immunology” This article reviews sebaceous immunobiology and highlights the complex role of sebaceous glands and sebocytes in skin barrier function and inflammation, particularly in acne pathogenesis, but reports no new results.
20 citations
,
April 2012 in “Fertility and Sterility” In this laboratory study with rats, treatment with finasteride reduced dihydrotestosterone levels and fertility parameters, with a 30-day recovery period proving insufficient to fully restore sperm function and fertility.
18 citations
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December 2020 in “Frontiers in cell and developmental biology” This study found that extracellular vesicles from low-passage dermal papilla cells may activate hair growth by delivering miR-140-5p, which downregulates BMP2 signaling, suggesting potential therapeutic targets for alopecia.
16 citations
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May 2020 in “Frontiers in pharmacology” This study found that minoxidil stimulates the Kir6.2/SUR2 potassium channel, leading to tumor growth arrest in an ovarian cancer xenograft model by disrupting mitochondrial function and inducing cell death.
16 citations
,
September 2016 in “Neuropharmacology” This study suggests that in an ex vivo rat glaucoma model, TSPO activation is involved in Allopregnanolone synthesis and may help prevent retinal damage, with TSPO agonists as potential therapeutic agents.
15 citations
,
April 2018 in “Revista Brasileira de Ginecologia e Obstetrícia” In this study of women with polycystic ovary syndrome, insulin resistance was associated with obesity, waist circumference, lipid accumulation, and hypertension, with no significant difference in prevalence between different diagnostic methods.
13 citations
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June 2016 in “Dermatologic Therapy” This study found that minoxidil applied to a damp scalp may increase drug penetration in vitro, potentially improving treatment effectiveness.
12 citations
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July 2020 in “International Journal of Pharmaceutics” This study found that finasteride- and dutasteride-loaded iron oxide nanoparticles improved drug penetration in the skin, suggesting they may be promising for topical alopecia therapies.
11 citations
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November 2020 in “bioRxiv (Cold Spring Harbor Laboratory)” This study observed that early treatment with azithromycin and either nitazoxanide, ivermectin, or hydroxychloroquine in COVID-19 patients may reduce viral shedding, symptom duration, and respiratory complications compared to untreated patients.
11 citations
,
July 2021 in “Nanomaterials” This study found that α-13′-carboxychromanol significantly accelerated wound healing and improved tissue quality in a mouse model, especially when delivered with bacterial nanocellulose under diabetic conditions.
8 citations
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December 2020 in “Skin appendage disorders” This study observed eyebrow regrowth in 7 patients with frontal fibrosing alopecia treated with low-dose oral minoxidil, suggesting it may be a promising treatment option, especially in early disease stages.
8 citations
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March 2018 in “Journal of Drug Delivery Science and Technology” This study found that treating paracoccidioidomycosis-infected mice with a nanoparticle formulation of itraconazole led to higher drug accumulation in lung, liver, and spleen tissues, improved treatment efficacy, and reduced side effects compared to traditional oral solutions.
7 citations
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December 2020 in “Dermatologic Therapy” In this study, intradermal injections of 0.5% minoxidil significantly improved hair growth and volume in women with female androgenetic alopecia compared to a placebo, with a good safety profile reported.