December 2019 in “RIUnB Institutional Repository (University of Brasília)” This study developed two types of polymeric nanoparticles containing clindamycin phosphate for potential topical acne treatment and found that the NP-AH-CDM-4 formulation preferentially penetrated hair follicles even with sebaceous obstruction, suggesting its promise for more effective acne therapy without causing skin irritation.
October 2019 in “Zenodo (CERN European Organization for Nuclear Research)” In this study, researchers developed a new solution called CapilGen, showing it increased hair quantity by 35% and density by 25% in clinical trials without side effects, providing a potentially safe and effective treatment for baldness.
August 2019 in “Journal of Investigative Dermatology” This study found that the desmosomal protein desmoplakin is crucial for proper epidermal morphogenesis and radial intercalation in developing Xenopus embryos, affecting keratin organization and ectodermal structures.
January 2018 in “VCU Scholars Compass (Virginia Commonwealth University)” In this study using Xenopus laevis embryos, reduced levels of the desmosomal protein desmoplakin led to defects in epidermal and cardiac structures, suggesting its crucial role in tissue integrity.
This review explores the synthesis and potential of azasteroids as novel drugs, discussing challenges in their production and reporting no new clinical results.
This chapter provides an overview of terminology for various skin lesions, including primary and secondary types, but does not report new findings or results.
April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology” The researchers reported that disrupting the RPGRIP1L gene in mice impaired desmosome function, causing skin blistering, and their findings suggest that PKCβII inhibition could help treat pemphigus.
January 2016 in “Graduate Medical Education Research Journal” This study identified AH01 derivatives and related compounds with high antischistosomal efficacy and reduced antiandrogenic effects, suggesting potential new directions for schistosomiasis drug development.
September 2015 in “Advances in small animal medicine and surgery” Deslorelin can help regrow hair in most intact male dogs with alopecia.
This review discusses the potential of using sustained release systems to increase the effectiveness and reduce side effects of 17-alpha-estradiol in alopecia treatment and reports no clinical results.
December 2013 in “Estudo Geral (Universidade de Coimbra)” This research investigated the design and synthesis of steroid-based compounds as aromatase inhibitors for breast cancer, finding that certain structural modifications significantly enhance their inhibitory potency.
July 2013 in “Pharmaceutical Regulatory Affairs Open Access” Formulation F1 is the best for delivering finasteride effectively.
January 2012 in “Journal of the Dermatology Nurses’ Association” The document explains hair growth, hair loss types, and other hair-related terms.
This study found that iontophoresis significantly increased folicular delivery of minoxidil sulfate and sustained release when combined with chitosan microparticles, suggesting potential to reduce application frequency for treating androgenic alopecia.
September 2008 in “Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature” Loss of Dsc3 function in the epidermis impaired cell adhesion, leading to blistering and hair loss, which suggests a potential cause of PV-like skin diseases according to this study.
April 2005 in “World Journal of Pharmaceutical and life sciences” This article discusses the formulation and evaluation of hair gels that may improve the treatment and prevention of dandruff by providing longer-lasting effects compared to traditional shampoos and lotions, but it reports no new clinical findings.
July 2004 in “DOAJ (DOAJ: Directory of Open Access Journals)” This preliminary study explores the role of melancholic mania in anorexia nervosa, noting it may reinforce the condition's difficult-to-reverse pathology and is often accompanied by poor self-esteem and maternal fixation.
This study found that Shh and Dhh overexpression in mouse basal cells led to similar epidermal and limb phenotypes, suggesting Dhh functions similarly to Shh in skin, unlike Ihh.
372 citations
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December 2004 in “Nature Genetics”
71 citations
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November 2012 in “Expert Opinion on Drug Safety” This article reviews the reported sexual and psychological side effects of 5-alpha reductase inhibitors for benign prostatic hyperplasia, emphasizing the need for further clinical studies.
39 citations
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January 2015 in “Journal of Electroanalytical Chemistry” In this study, a novel electrochemical sensor using a molecularly imprinted polymer was developed for the sensitive detection of minoxidil, successfully measuring its concentration in real samples.
25 citations
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November 2008 in “Facial Plastic Surgery” This article explores factors in designing a personalized hairline, favoring a flared design approach, and reports no new evidence.
23 citations
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October 2008 in “Journal of medicinal chemistry” This study suggests that PF-0998425 is an effective androgen receptor antagonist for sebum control and androgenetic alopecia with rapid metabolism reducing the risk of systemic side effects.
22 citations
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January 2013 in “International Journal of Trichology” Hair loss is often linked to thyroid problems, especially in women and older people, and screening for thyroid issues is advised for those with hair loss.
18 citations
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May 2010 in “Zentralblatt für Veterinärmedizin Reihe A” This study concluded that hair zinc levels in weaned male rats do not reliably indicate their overall zinc status, as varying dietary zinc levels produced inconsistent hair zinc concentrations.
16 citations
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March 2017 in “Oncotarget” This study suggests that SOCS3 treatment may effectively inhibit alopecia areata by suppressing CD8+ T cell activity and IFN-γ production.
15 citations
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June 2023 in “Journal of Microbiology and Biotechnology” In this study, researchers found that an ethyl acetate extract of the green microalga Scenedesmus deserticola significantly increased the viability of human dermal fibroblasts by over 20% compared to a control and identified a potent anti-UV compound, loliolide, through further fractionation.
13 citations
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September 2017 in “Skin appendage disorders” Some women with Frontal Fibrosing Alopecia also have Lichen Planopilaris, which can lead to more symptoms and affect hair outside the scalp.
12 citations
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March 2004 in “Der Urologe” This review of studies on prostate cancer chemoprevention in Europe reports no robust evidence supporting the effectiveness of chemopreventive agents, though vitamin E and selenium may potentially contribute to prevention efforts.
12 citations
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July 2004 in “Molecular genetics and genomics” This study identifies a new mutation in the Scd1 gene in a strain of Kunming mice, causing skin and hair defects with the mildest impact among similar mutations.