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This study found that sorafenib was active against desmoid tumors, with 25% of patients achieving a partial response and 70% maintaining stable disease.

This study found that desmocollin 1 is crucial for strong adhesion and barrier maintenance in the mouse epidermis, with its absence leading to skin and hair issues resembling chronic dermatitis.

This study reports that three synthesized PSMA-targeted radioimaging agents demonstrated high affinity and specific localization to prostate cancer tumors in a mouse model, highlighting their potential for cancer detection and monitoring.

This study synthesized nonsteroidal ligands as second-generation androgen receptor agonists and identified three compounds with significant anabolic activity and moderate to minimal androgenic activity in vivo.

This review summarizes numerous studies on adhesive hydrogels with natural antibacterial agents for wound dressings, highlighting their potential as effective treatments with strong antibacterial properties, biocompatibility, and mechanical performance, while minimizing reliance on antibiotics.

This study found that overexpressing Dsg3 in the suprabasal epidermis of transgenic mice resulted in flaking skin and abnormal hair growth, supporting Dsg3's role in regulating epidermal differentiation.

This study suggests that deregulation of sonic and desert hedgehog signaling in mouse skin can lead to altered epidermal stem cell activity and lesions similar to human basal cell carcinoma, indicating these cancers may originate outside the stem cell population.

This study demonstrated that murine monoclonal antibodies can reveal specific patterns of desmosomal cadherin expression, Dsc1 and Dsc3, in human tissues and cultured cells using immunofluorescence microscopy.

The researchers found that corneodesmosin is crucial for maintaining skin barrier integrity and hair follicle architecture in mice, with its deletion leading to severe skin and hair abnormalities.

This review highlights the development and current status of biopolymer-based hemostatic materials, presenting common strategies, material design from both microscopic and macroscopic perspectives, challenges, and future directions for improving hemostasis in surgical and emergency settings.

This review highlights the promising potential of 3D printing for creating microneedles with precise customization and improved performance compared to traditional micromolding, emphasizing applications in personalized medical devices and advancements in biomedical fields.

Mutations in the DSG4 gene cause specific hair and scalp issues.

This study identified novel compound heterozygous mutations in the DSG4 gene in a Japanese patient with congenital hypotrichosis, suggesting overlap between localized autosomal recessive hypotrichosis and monilethrix.

This study provides genetic evidence that desmoglein-1 can compensate for the loss of desmoglein-3 in hair adhesion, supporting the desmoglein compensation hypothesis.

In this study, treatment with the oral contraceptive containing 30 μg ethinyl oestradiol and 150 μg desogestrel significantly reduced androgen-dependent hair growth in hirsute women over one year.

This review examines the design strategies for creating conductive hydrogels with adjustable properties for various biomedical applications, highlighting their potential for supporting cell growth, wound healing, drug delivery, tissue regeneration, and biosensing.

This study suggests that finasteride-loaded liquid crystalline nanoparticles could be a viable alternative to oral administration for treating androgenetic alopecia due to their controlled release and skin permeation properties.

This study found that an 8-month treatment with a low-dose oral contraceptive significantly reduced testosterone levels and hair growth in women with polycystic ovary syndrome and hirsutism, with minimal side effects.

This study suggests that a sandwich-structured wound dressing with bioceramic and polylactic acid layers may improve burn wound healing by absorbing exudates and promoting hair follicle regeneration.

This study identified a missense mutation in the rat Desmoglein 4 gene, causing abnormal hair shaft development in lanceolate hair mutant rats by disrupting a critical calcium binding site.

This study observed that 13 out of 38 children with methylmalonic and propionic acidaemia exhibited specific cutaneous manifestations, suggesting these conditions may include skin symptoms more often than previously thought.

This study found that polymeric nanoparticles may effectively deliver finasteride topically to hair follicles, potentially improving alopecia treatment with fewer side effects than oral forms.

This study found that cationic lipid-based formulations enhanced the delivery of large molecules into hair follicles in human scalp skin, with potential to reach pharmacologically active concentrations in the hair bulb.

In this study, researchers created a novel fibrous membrane inspired by ancient Chinese medicine that effectively promotes hair follicle regeneration and wound healing in deep burn injuries by releasing quercetin, copper, and silicon ions.

This study found that novel androgen antagonists incorporating a carborane moiety showed anti-androgenic activity comparable to flutamide in a laboratory setting.

A gene deletion in DSG4 causes sparse hair in some Pakistani families.

In this study, niacinamide 4% and desonide 0.05% emulsions significantly improved axillary hyperpigmentation in women, with desonide demonstrating a superior depigmenting effect compared to niacinamide and placebo.

This review discusses recent research and applications of RADA16 and RADA16-based peptide scaffolds in biomedicine, including their roles in tissue repair and drug delivery, but reports no new clinical results.

Finasteride may help reduce symptoms in male Tourette syndrome patients.

This study found that in androgenic alopecia, the arrector pili muscle degenerates and is replaced by fat, unlike in normal skin or telogen effluvium.