12 citations
,
September 2018 in “Journal of Drug Delivery Science and Technology” This study found that a new hydrogel formulation of basic fibroblast growth factor showed promise in promoting hair regrowth and reducing inflammation in testosterone-treated mice.
5 citations
,
November 2025 in “Biomolecules” This review examines the benefits of topical hyaluronic acid in cosmetic applications, noting its ability to penetrate the skin in low-molecular-weight forms and highlighting safety supported by clinical trials.
January 2025 in “Indian Journal of Dermatopathology and Diagnostic Dermatology” In this histopathology study of nevus sebaceus, researchers observed distinct epidermal, sebaceous, follicular, and apocrine changes, including sebaceous hyperplasia and basaloid adnexal proliferation, which help differentiate it from similar conditions like basal cell carcinoma and trichoblastoma.
May 2024 in “Journal of colloid and interface science” This study developed a bilayer bionic skin scaffold that mimics the skin's structure to resist microbial invasion and enhance wound healing, with in vivo animal studies showing improved collagen deposition, neovascularization, and hair follicle formation.
January 2024 in “Toxicologic Pathology” This review outlines the structure and functions of the skin, emphasizing its role as a physical and immune barrier, its moisture regulation, the influence of its microbiome, and the supportive functions of its layers and adnexa.
This study found that the succinate receptor, GPR91, plays a crucial role in the progression of androgenetic alopecia by affecting the immune system and hair follicle biology, and targeting it may offer new therapeutic strategies.
July 2022 in “The journal of investigative dermatology/Journal of investigative dermatology” This study found that carefully engineered hydrogels and asymmetric morphogen gradients facilitated the formation of anatomically relevant skin organoids from iPSC-derived EBs, improving pigmentation and hair follicle generation.
This study found that proretinal nanoparticles, applied topically, are safe and effective for penetration into hair follicles, enhancing retinoid biological activity in the skin while reducing irritation compared to conventional retinal formulations.
December 2009 in “Journal of Veterinary Clinics” The authors diagnosed a 5-year-old Pekinese dog with keratoacanthoma with granulomatous inflammation, and the mass did not recur 5 months after surgical removal.
21 citations
,
December 2017 in “bioRxiv (Cold Spring Harbor Laboratory)” This study found that fibroblast behavior switching between proliferation and ECM deposition is vital for dermal architecture, where cell migration is primarily important for tissue repair during wound healing.
December 2023 in “Communications biology” This study found that inhibiting the HEDGEHOG-GLI1 pathway could reduce keloid size and gene expression, suggesting it as a potential therapeutic target for keloid pathogenesis.
147 citations
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April 2004 in “PubMed” This study identifies specific localization patterns of androgen, estrogen, and progesterone receptors in human skin, which could be crucial for understanding their roles in skin biology and pathology.
138 citations
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June 2012 in “Genes & Development” This study found that dermal Shh signaling regulates specific dermal papilla signatures essential for maintaining hair follicle development, suggesting that the Shh-Noggin signaling loop is crucial for hair morphogenesis.
124 citations
,
July 1997 in “Journal of Biological Chemistry” This study found that overexpression of an enzyme in transgenic mice led to distorted polyamine levels, resulting in permanent hair loss and female infertility.
74 citations
,
November 2000 in “Archives of Dermatology” In this study, application of salicylic acid solution on mouse skin showed histologic changes without causing wounds or inflammation, observed immediately and up to 48 hours after treatment.
68 citations
,
December 1983 in “British Journal of Dermatology” This study found HLA and beta 2-microglobulin antigens in various skin structures, with specific localization patterns in keratinocytes and hair follicle components, but not in eccrine or apocrine glands.
66 citations
,
December 2014 in “Nature Communications” Fibroblasts can be turned into melanocytes for potential skin treatments.
62 citations
,
October 2010 in “Journal of biomedical nanotechnology” This review discusses the challenges and contradictions in understanding nanoparticle penetration and toxicity in human skin, emphasizing the need for standardized testing and further research on particles smaller than 10 nm.
51 citations
,
April 2020 in “Cells” This study found that macrophage extracellular vesicles enriched with Wnt proteins significantly promoted hair follicle growth in mice and increased hair shaft size in human hair follicles, suggesting potential clinical use for treating hair loss.
26 citations
,
January 2022 The skin is essential for protection, temperature control, and immune defense.
17 citations
,
May 1969 in “American Journal of Physical Anthropology” This study describes unique anatomical characteristics of the skin and hair structures in the silver marmoset, including features such as thin epidermis, specialized nerve end-organs, and distinctive gland compositions.
15 citations
,
November 2009 in “Journal of Comparative Pathology” Epidermolysis bullosa in calves was not caused by mutations in the keratin genes bKRT5 and bKRT14.
14 citations
,
May 2022 in “Stem cell reports” This study reported that human induced pluripotent stem cell-derived skin organoids, used to model epidermolysis bullosa, have an epidermal-dermal junction largely lacking type VII collagen, which is important for skin structure.
14 citations
,
January 2021 in “Scientific Reports” This study found that "micro skin tissue columns" improved wound healing by enhancing re-epithelialization, collagen deposition, dermal remodeling, and reducing inflammation without causing long-term donor site morbidity.
13 citations
,
March 1998 in “Journal of Biomedical Materials Research” This study found that island grafting in guinea pigs enabled the isolated study of early skin regeneration processes, distinguishing them from natural wound closure mechanisms like epithelialization and contraction.
7 citations
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January 2002 in “PubMed” This study observed significant skin changes, including epidermal thickening and pleomorphic keratinocytes, in rats after subchronic UVB irradiation, highlighting specific reactions in the dorsal skin.
7 citations
,
January 1990 in “Archives of Dermatological Research” Syringomas likely start in the upper dermis and form distinct luminal structures.
6 citations
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January 2019 in “Journal of feline medicine and surgery open reports” This case report describes the first known occurrence of urticaria pigmentosa in a domestic shorthair cat, where oral dexamethasone and cetirizine hydrochloride offered effective management following a comprehensive diagnostic work-up.
6 citations
,
January 1967 in “Journal of Small Animal Practice” This study observed that aged dogs exhibit atrophy of the epidermis, appendages, and dermis, along with variable skin changes and increased dermal pigmentation, but lack senile elastosis seen in humans.
5 citations
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January 2016 in “Elsevier eBooks” This study found that combining AMD-3100 with FK506 in subimmunosuppressive doses enhanced stem cell release from bone marrow, resulting in 25% faster epithelialization in excisional wounds in rats and mice.