94 citations
,
August 1975 in “Journal of Cutaneous Pathology” In this study, the researchers observed that male pattern alopecia is characterized by miniature follicles, enlarged sebaceous glands, and an increased number of mast cells, without significant abnormalities in enzyme activity.
69 citations
,
November 2023 in “Heliyon” This abstract discusses the importance of developing intelligent and multifunctional dressings with skin-like properties for real-time wound monitoring, highlighting their potential to improve wound management, prognostic evaluation, and the integration of health monitoring into clinical practice.
67 citations
,
September 2017 in “Cell Reports” Caloric restriction improves skin and fur structure but can cause muscle loss and movement issues.
47 citations
,
November 2012 in “Pharmaceutical research” This study found that surface modified nanoparticles showed increased skin permeation and improvement in allergic contact dermatitis, independent of the follicular pathway.
45 citations
,
July 2009 in “Journal of Investigative Dermatology” This study reported significant upregulation and release of S100A4 in psoriatic skin, which may actively contribute to psoriasis pathogenesis.
33 citations
,
December 2004 in “Differentiation” In this study, mouse amnion epithelium was successfully transformed into skin and hair follicles when associated with hair-forming dermis, revealing the necessity of specific influences for follicle formation.
28 citations
,
November 2020 in “Journal of Controlled Release” In this study, microneedles combined with finasteride nanostructured lipid carriers (FIN-NLC-MNs) were found to enhance skin penetration and specifically target hair follicles, promoting hair growth and gene regulation in androgenetic alopecia.
28 citations
,
June 1995 in “The Journal of Dermatology” This study reports that flaky skin mice exhibit skin and nail features that closely resemble human psoriasis vulgaris, suggesting they may serve as a natural model for this condition.
27 citations
,
July 2020 in “Stem Cells International” This study observed that while PRP therapy increased inflammation and fibrosis in photoaged skin, ADSCs therapy showed promising antiaging effects by promoting elastin and fibrillin formation and remodeling the dermis.
27 citations
,
January 2002 in “Exogenous Dermatology” In this study, researchers reported that chronic UV exposure may contribute to androgenic alopecia progression by influencing hair cycle changes and exacerbating solar elastosis in the scalp.
21 citations
,
October 2007 in “Journal of Investigative Dermatology” Fetuin-A helps wounds heal without scars by promoting cell movement.
11 citations
,
September 2019 in “The journal of investigative dermatology/Journal of investigative dermatology” This study identified a distinct CD49fhigh mesenchymal stem cell subpopulation in the dermis that supports hair follicle development and maintenance via Notch signaling activation.
9 citations
,
February 2021 in “Frontiers in Cell and Developmental Biology” This review discusses the role of tissue mechanics and extracellular matrix in skin aging processes and highlights potential therapeutic strategies, but reports no new clinical results.
9 citations
,
June 2017 in “The American journal of dermatopathology/American journal of dermatopathology” This study examined skin biopsies from a woman with Addison disease and found melanocytic hyperpigmentation in the epidermis, with a notable melanocyte/keratinocyte ratio indicating increased melanocyte presence in the arm compared to the thigh.
9 citations
,
October 1976 in “Journal of Cutaneous Pathology” This study observed that human growth hormone treatment in osteoporosis patients appeared to improve skin thickness and restore dermal structures towards normal without stimulating hair, sebum, or melanin.
8 citations
,
June 2019 in “Pharmaceutical research” This study found that using short durations of heat with chemical penetration enhancers improved isotretinoin delivery to human skin, especially via the hair follicles.
5 citations
,
January 2019 in “Elsevier eBooks” This chapter reviews skin components, wound healing mechanisms, and the potential of biomaterials to enhance skin repair and regeneration, without offering new experimental results.
4 citations
,
September 2012 in “Journal of dermatological science” The hair follicle's connective tissue is a key source of a certain collagen in human scalp skin.
3 citations
,
January 2018 in “Methods in molecular biology” This paper describes a protocol for isolating and culturing skin-derived precursors to potentially induce hair growth and regenerate hair follicles, but reports no new experimental findings.
2 citations
,
December 2022 in “Journal of toxicologic pathology” This review outlines the histological structures of the skin, highlighting species and regional differences in dermal absorption and obstacles encountered in toxicological assessments due to epidermal thickness variability, contact dermatitis reactions, and stem cell vulnerabilities.
1 citations
,
March 2014 in “Applied Microscopy” This study confirmed the localization of CK19 and vimentin in skin cells, with CK19 linked to hair growth and vimentin stabilizing fibroblast structure.
July 2026 in “Journal of Investigative Dermatology” Tissue stiffness affects sweat gland development by guiding cell differentiation through specific signals.
July 2024 in “Journal of Investigative Dermatology” CD8+ T cells attack hair follicle stem cells, causing scarring and hair loss in Discoid Lupus.
July 2023 in “Clinical, cosmetic and investigational dermatology” In this study, reflectance confocal microscopy was used to diagnose periorificial dermatitis, revealing specific skin changes such as hair follicle dilatation, increased vascular density, and inflammation, which help distinguish it from similar conditions.
This review discusses the effectiveness of adipose-derived stem cells in treating alopecia, reporting on various clinical studies but presenting no new clinical results.
This article discusses the effects of ablative carbon dioxide laser treatment for skin rejuvenation, noting it requires only a single treatment but involves more complex postoperative management, without reporting new clinical outcomes.
July 2020 in “Experimental Dermatology” This discussion of age-related changes in female scalp hair follicles reports no new results, highlighting the structural transformations that may contribute to thinning hair in women as they age.
April 2018 in “Veterinary Pathology” This study describes a form of lymphocytic mural folliculitis in tigers causing hair loss, concluding it may represent a nonspecific hypersensitivity reaction distinct from T-cell lymphoma.
This abstract discusses the mechanism and effects of ablative carbon dioxide laser treatment for skin tightening, reporting no new clinical results but noting the need for involved postoperative management.
January 2005 in “中华医学杂志:英文版” This study found that residual sweat glands in hypertrophic scar tissues may regenerate from adult epidermal stem cells or residual glands after burn injury.