40 citations
,
January 2009 in “Skin Pharmacology and Physiology” This review discusses the potential use of cultured primary fetal cells from a single organ donation to produce therapeutic products, emphasizing the need for process consistency and safety verification, but reports no clinical results.
39 citations
,
May 2010 in “Stem Cells” This study reported that disrupting ephrin-Eph interactions in adult mouse skin doubled cell proliferation in the hair follicle and epidermis, suggesting ephrins as negative regulators of proliferation.
39 citations
,
March 2008 in “Journal of biological chemistry/The Journal of biological chemistry” This study found that GLI2 plays a key role in activating follistatin, an activin/BMP antagonist, in response to hedgehog signaling in human epidermal cells, with implications for hair follicle development and basal cell carcinoma.
35 citations
,
November 2020 in “Experimental Dermatology” This study found that upper wound fibroblasts are crucial for hair follicle regeneration during wound healing and suggests that these cells, along with papillary fibroblasts, migrate within the wound.
33 citations
,
June 2017 in “Developmental Biology” This study found that local refinement of hair follicles into higher order patterns can occur without the core planar cell polarity system, but global alignment with body axes requires its function throughout development and regeneration.
33 citations
,
September 2016 in “British journal of dermatology/British journal of dermatology, Supplement” This study found that human hair follicle dermal cells, specifically dermal sheath cells, can serve as an alternative and potentially superior cell source for constructing the dermal component of bioengineered skin in both in vitro and in vivo settings.
33 citations
,
April 2012 in “British Journal of Dermatology” This review discusses the role of stem cells in alopecia pathogenesis, highlighting the differences between scarring and nonscarring types, and reports no new clinical results.
30 citations
,
April 2017 in “Experimental Dermatology” This review explores the role of hair follicle dermal stem cells in skin regeneration and restorative therapies, but it reports no new experimental results.
29 citations
,
February 2013 in “Proceedings of the National Academy of Sciences of the United States of America” This study found that Merkel cell clusters require Frizzled6 signaling for their polarity information, while other hair follicle-associated structures align their orientation based on the hair follicle itself.
23 citations
,
December 2020 in “Frontiers in Cell and Developmental Biology” This review explores recent insights into how intrinsic gene oscillations and molecular interactions in hair follicle stem cells contribute to their regenerative potential, with potential implications for regenerative medicine, but reports no new clinical results.
22 citations
,
June 2013 in “International journal of molecular sciences” This review discusses the mechanisms governing epidermal stem and progenitor cell differentiation, emphasizing the balance necessary for maintaining skin barrier function, and reports no new experimental findings.
19 citations
,
February 2016 in “Journal of The American Academy of Dermatology” This study found that the presence of CD3(+) T-cells within empty follicular fibrous tracts is a reliable indicator for diagnosing diffuse alopecia areata instead of pattern hair loss.
19 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” The researchers reported that hair follicle germinative epidermal cells can form complex structures when associating with papilla cells in culture, unlike other types of epidermal cells.
18 citations
,
November 2013 in “Molecules and Cells” This study found that a novel 3D in vitro culture condition improved stemness markers and proliferation potential in human dermal stem/progenitor cells compared to traditional 2D methods.
16 citations
,
February 2019 in “Gene” This study describes two methods for isolating hair follicle stem cells from newborn Yangtze River Delta White Goats, highlighting differences in cell viability and marker protein expression between the methods.
14 citations
,
September 2018 in “Biochemical and Biophysical Research Communications” This study suggests that co-culturing human outer root sheath cells with human dermal papilla cells can restore their ability to induce hair growth by altering gene expression through paracrine signaling.
13 citations
,
January 2022 in “Stem cell reviews and reports” This study found that using cultured mesenchymal stem cells from mouse whisker hair follicle outer root sheath in wound healing reduced inflammation, accelerated closure, and resulted in less hypertrophic scarring in mice.
13 citations
,
December 2014 in “Stem Cells” This study found that quiescent bulge stem cells, when prevented from contributing to hair follicle and epidermal regeneration, did not affect hair follicle growth or wound healing in the short term.
12 citations
,
June 2019 in “The journal of pharmacology and experimental therapeutics/The Journal of pharmacology and experimental therapeutics” This study found that inhibiting the TRPV3 channel may significantly promote hair growth and suggests a potential therapeutic approach for hair loss and related skin diseases.
12 citations
,
December 2002 in “Archives of Dermatology” This case report describes a 49-year-old woman with Sweet syndrome who experienced complete resolution of skin lesions after a prednisone treatment regimen.
11 citations
,
October 2018 in “The Journal of Dermatology” This study suggests that decorin may help maintain hair follicle stem cells and its reduced expression could contribute to age-related hair loss.
10 citations
,
July 2021 in “Archiv für Pathologische Anatomie und Physiologie und für Klinische Medicin” This study found that the expression of LRIG1 in Merkel cell carcinoma tumors was associated with improved overall and cancer-specific survival.
9 citations
,
February 2014 in “Tissue Engineering and Regenerative Medicine” This study found that conditioned media from human amniotic fluid-derived stem cells may enhance skin regeneration by promoting cell proliferation and migration, and by modulating gene expressions altered by UV irradiation.
8 citations
,
November 2020 in “Frontiers in Cell and Developmental Biology” This study reported that exogenous R-spondin-1 can restore hair follicle neogenesis in adult mouse cells, highlighting differences in gene expression and signaling pathways between fetal and adult dermal papilla cells.
7 citations
,
September 2024 in “Applied Microbiology and Biotechnology” In this study, researchers observed that Malassezia species show different lipid metabolism and growth patterns depending on pH, with slightly acidic conditions promoting beneficial lipid bio-conversion for skin health, while neutral pH resulted in lower growth and lipid content, potentially negatively impacting the skin.
7 citations
,
April 2014 in “Cell biology international” This study found that melatonin treatment increased epidermal thickness, subcutaneous fat, and dermal-related factors in postmenopausal rats, suggesting benefits for skin structure after menopause.
5 citations
,
December 2017 in “Tissue and cell/Tissue & cell” This study observed that skin stem cells in dogs could be identified using CD34 and CD200 markers, although further refinement in isolation and cultivation methods is needed for better identification.
3 citations
,
October 2024 in “Frontiers in Medicine” This study investigated single-cell changes in photoaged skin, revealing distinct cell clusters and increased activity in PD-L1 and PD-1 pathways in sun-exposed areas, enhancing understanding of UVA-induced skin damage and potential prevention targets for photoaging and UV-induced skin cancers.
3 citations
,
May 2018 in “European Journal of Dermatology” Photodynamic therapy may not work for erythroplasia of Queyrat and could lead to invasive squamous cell carcinoma.
3 citations
,
January 2014 in “Arhiv za farmaciju” This article discusses the role and potential of plant stem cell extracts in cosmetics for their antioxidant and protective effects on skin cells, reporting no new clinical results; the authors highlight ecological and sustainable production methods.