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This study developed a rapid, cost-effective three-dimensional skin equivalent model using human dermal fibroblasts, collagen, and hair follicles, which closely resembles natural human skin and can be used for autologous transplantation.

This study developed a prototype pneumatic dual-cell implanter that successfully stacked and implanted cells in tests, reducing hand burden for operators, which may improve alopecia treatments compared to traditional hair transplantation.

This study reported that a skin equivalent model using human outer root sheath cells and fibroblasts showed the formation of structures similar to human dermis and epidermis within two weeks after transplantation into mice.

This review discusses genomic and postgenomic alterations in chronic degenerative diseases and potential modulation by dietary and pharmacological agents, reporting no new clinical results.

This review highlights the potential of microfluidic skin-on-a-chip models in skin research, emphasizing their ability to mimic human skin structure and improve control over cellular and molecular distribution compared to traditional in vitro models.

In this study, researchers developed self-assembled skin models derived from hair follicle cells, offering an ethical and reliable alternative to animal testing and bovine collagen in dermatological research by providing functional dermal and epidermal layers for substance evaluation.

This study demonstrated that a 3D bioprinting technique using a gelatin/alginate hydrogel scaffold can regenerate entire hair follicles in mice, offering potential advancements in hair loss treatment.

This study introduces a new multiaxial bioreactor system that uniformly stretches tissue-engineered skin grafts and improves skin tissue maturation through enhanced cellular distribution and environmental monitoring.

This review discusses the use of human-to-mouse xenografting to study human skin processes in vivo, highlighting its importance for understanding skin regeneration and pathology while identifying knowledge gaps and challenges in applying these findings to human skin.

This study found that administering an adenovirus vector to increase Sonic hedgehog gene expression in mouse skin accelerated the transition of hair follicles into the growth phase, promoting hair growth.

This study found that Runx3 deficiency in mice affects hair type and shape, suggesting it may regulate hair formation through interactions between dermal and epidermal layers.

This study introduces a spherical skin model that effectively mimics key features of human skin, offering a scalable and rapid alternative for non-animal dermatological and cosmetic testing.

This study found that WWOX deficiency in mice leads to impaired skin development, reduced epidermal thickness, and significant hypothermia due to disrupted cell proliferation and homeostasis.

This study found that transplanting hair follicle bulge-derived stem cells in rats enhanced skin regeneration during expansion by differentiating into several skin-related cells and increasing the expression of growth factors.

This study demonstrates that young coconut juice appears to have estrogen-like properties that can accelerate wound healing in ovariectomized rats.

The researchers concluded that baicalin may promote hair growth and follicle proliferation by activating the AKT pathway, suggesting its potential as a treatment for alopecia.

This study observed that testosterone metabolism and androgen receptor localization differ significantly across body sites, with beard hair follicles showing distinct characteristics compared to occipital scalp hair follicles.

This study demonstrated that engineered exosomes carrying EGF and FGF restored hair density and follicle integrity in an androgenetic alopecia mouse model by reactivating hair follicle growth factors, offering a novel therapeutic approach without immunogenic reactions or systemic toxicity.

In this study, researchers found that fermented ginsenoside from kimchi-derived bacteria enhanced hair growth in a mouse model and increased hair cell proliferation by 25% in vitro, suggesting potential as a therapeutic candidate for promoting hair growth.

This study provides a detailed analysis of cell subpopulations in a mouse model of wound-induced hair follicle regeneration, revealing specific cellular dynamics and heterogeneity that may influence hair follicle neogenesis.

The study demonstrated that bulge stem cells from rat vibrissa follicles respond to adult dermal papilla signals, inducing hair bulb formation and regenerating hair structures in vivo.

This review discusses the complex interaction between androgens and hair follicle biology, highlighting the need for a better understanding to improve hirsutism treatments, but reports no new results.

This study suggests that cultured human hair follicle cells can potentially recreate epidermis and produce bioengineered hair follicles in a GMP cell factory for regenerative therapy in alopecia.

This study evaluated a novel synthetic cell-penetrating peptide, DualPep-ALO, finding it promotes hair growth by enhancing follicle cell proliferation, activating regenerative pathways, and reducing inflammation and oxidative stress in vitro and ex vivo, suggesting a promising new topical treatment for hair loss that rivals minoxidil.

This study found that testosterone and dihydrotestosterone can induce growth factors from dermal fibroblasts, promoting keratinocyte proliferation and differentiation, which may contribute to sex hormone-related acne development.

In this study, AgK114 was found to be transiently induced in hamster epidermal keratinocytes following skin damage, suggesting its role in the recovery process after injury.

This article provides contact information for Bruce A. Morgan and features no new research findings.

This study found that dermal papilla and sheath cells can induce hair follicle formation in vitro and in vivo by interacting with hair follicle epithelial cells.

In this study, researchers found that the interaction between dermal papilla and endothelial cells decreases with age, affecting signaling pathways that promote hair regeneration and angiogenesis in mouse models.

This review summarizes recent discoveries about how tissue-resident stem cells interact with their environments during normal conditions and after injury, without reporting new results.