34 citations
,
July 1993 in “The journal of investigative dermatology/Journal of investigative dermatology” This study suggests that androgens influence hair follicle behavior via the dermal papilla, using evidence from human and red deer cells with differing androgen responses as models.
32 citations
,
February 2024 in “Growth Hormone & IGF Research” In this study, DHT was found to inhibit hair growth in mice by decreasing IGF-I production in dermal papillae through reduced sensory neuron stimulation.
32 citations
,
April 2017 in “Scientific Reports” This study found that 5% activated platelet-rich plasma significantly improved cell proliferation and hair-inductive ability of dermal papilla cells in vitro, and promoted hair follicle formation in mice.
32 citations
,
July 2012 in “Stem Cells Translational Medicine” In this study, VD(3) pretreatment increased hair follicle formation in a rat model by promoting dermal papilla cell differentiation, suggesting potential for hair regeneration therapy.
23 citations
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January 2018 in “International Journal of Molecular Medicine” This study reported that baicalin activates the Wnt/β-catenin signaling pathway in mouse hair follicles, suggesting its potential as a topical treatment for hair loss.
22 citations
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October 2012 in “Cell Transplantation” This study found that adding Wnt-10b to the culture medium of dermal papilla cells maintained their ability to induce hair follicles over 100 days in vitro.
22 citations
,
April 2006 in “Journal of Dermatological Science” This study reports that versican expression plays a crucial role in maintaining the anagen phase and hair inductive properties, as shown in a transgenic mouse model and hair growth assays.
21 citations
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March 2018 in “Experimental Dermatology” This practical guide introduces methods to study human dermal white adipose tissue but does not report new clinical results, emphasizing available techniques and staining protocols.
20 citations
,
June 2020 in “Journal of Cosmetic Dermatology” This study found that hypoxia increases the proliferation of dermal papilla cells and highlighted the important role of lactate dehydrogenase in this process.
20 citations
,
August 2015 in “International Journal of Molecular Medicine” This study found that human placental extract promoted hair growth and influenced cellular pathways in vitro and rat models, suggesting potential for future hair loss treatments.
19 citations
,
January 1997 in “Endocrinology” This study observed that testosterone inhibits hair follicle epithelial cell proliferation in adult stumptailed macaques only when dermal papilla cells from bald scalps are present, with antiandrogen RU 58841 reversing this effect.
18 citations
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April 2019 in “Archives of Dermatological Research” This study found that bovine lactoferrin promotes hair growth in mice by enhancing dermal papilla cell proliferation through the Erk/Akt and Wnt signaling pathways.
18 citations
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January 2019 in “Animal Biotechnology” This study found that lncRNA-000133 may play a role in secondary hair follicle reconstruction and cashmere fiber growth in goats, potentially through its interaction with the methylation of its regulatory region and dermal papilla cells.
18 citations
,
July 2022 in “Chemistry - an Asian journal” This study found that GelMA/HAMA bioink shows promise for 3D printing skin equivalents, as it effectively mimics the native skin's properties and supports hair follicle structure development.
17 citations
,
February 2016 in “Experimental Dermatology” This study found that SFRP2 enhances Wnt3a-mediated β-catenin signaling in human dermal papilla cells, with higher SFRP2 expression in beard cells correlating with increased trichogenicity.
16 citations
,
October 2018 in “Biochemical and Biophysical Research Communications” In this study, sildenafil was found to enhance human dermal papilla cell proliferation and promote hair growth in mice, suggesting potential use in alopecia treatment.
15 citations
,
October 2012 in “InTech eBooks” Niosomes are a promising and effective way to deliver drugs through the skin.
14 citations
,
May 2020 in “Biomolecules & Therapeutics” This study found that vanillic acid from wheat bran promoted dermal papilla cell proliferation, potentially stimulating hair growth by activating the PI3K/Akt and Wnt/β-catenin pathways.
13 citations
,
December 2021 in “Wound repair and regeneration” This study found that photobiomodulation enhanced hair regeneration in injured dermis of mice, likely through increased migration and exosome secretion of dermal papilla cells via the Akt/GSK-3β/β-catenin pathway.
13 citations
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July 2019 in “Journal of Biochemical and Molecular Toxicology” In this study on rat dermal papilla cells, hydroxytyrosol, an antioxidant found in olive oil, was reported to protect against oxidative stress, reduce inflammation, and enhance hair growth factors, suggesting its potential to prevent hair loss.
13 citations
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October 2017 in “Bioscience, Biotechnology, and Biochemistry” This study found that a titrated extract of Centella asiatica enhanced the hair growth potential of 3D spheroid cultured human dermal papilla cells.
13 citations
,
March 2013 in “International Journal of Cosmetic Science” This study reports that the tetrapeptide AcSDKP significantly promotes skin and hair health in vitro and ex vivo, suggesting it could be used cosmetically to counteract skin aging and hair loss.
11 citations
,
August 2021 in “Aging” This study found that TGF-β2 may enhance collagen expression and spheroid formation in human dermal papilla cells, which could improve their hair inductivity and maintenance.
9 citations
,
August 2018 in “Biomedical dermatology” This study found that topical administration of the TGFβ mimetic peptide DPS-1 stimulated hair growth in mice by promoting HDP cell proliferation and enhancing hair follicle morphology.
8 citations
,
February 2021 in “Biomolecules & therapeutics” This study found that myristoleic acid promotes dermal papilla cell proliferation and anagen signaling through autophagy, cell cycle progression, and activation of the Wnt/β-catenin and ERK pathways.
7 citations
,
March 2022 in “Molecules” This study found that 5-bromo-3,4-dihydroxybenzaldehyde (BDB) promoted hair growth in rat vibrissa follicles by activating Wnt/β-catenin and autophagy pathways and inhibiting the TGF-β pathway in dermal papilla cells.
7 citations
,
March 2021 in “Biology” This study found that silk fibroin/sodium alginate scaffolds seeded with dermal papilla cells may accelerate skin repair and hair follicle regeneration in a rat model.
7 citations
,
March 2021 in “Molecular Medicine Reports” This study demonstrated that culturing high-passage dermal papilla cells with specific supplemented conditioned media may preserve their hair-inducing abilities, suggesting potential for reconstructing new hair follicles in vivo.
6 citations
,
July 2022 in “World journal of stem cells” This study found that human mesenchymal stem cell-derived extracellular vesicles promote the proliferation and migration of hair follicle cells and increase hair shaft elongation in cultured human hair follicles.
6 citations
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January 2020 in “Skin Pharmacology and Physiology” This study demonstrated that caffeine, minoxidil, and the HIF-1α-stimulating agent deferiprone significantly enhanced dermal papilla cell proliferation in a 3D culture model, suggesting deferiprone as a potential alternative to minoxidil.