19 citations
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October 1996 in “Dermatologic Clinics” This review discusses using cultured dermal papilla cells to investigate hair follicle biology, emphasizing their potential to inform treatments, but reports no new clinical results.
January 2006 in “Journal of Clinical Dermatology” Medications used in mesotherapy can affect hair growth and the cells that help hair grow.
31 citations
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August 2019 in “Regenerative Medicine” This study found that the human placenta extracellular matrix hydrogel restored the hair-inductive capacity of high-passaged dermal papilla cells, enabling them to regenerate new hair follicles when co-grafted with mouse epidermal cells.
4 citations
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April 2001 in “Experimental Dermatology” This study used a novel HPLC-radiomatic flow scintillation system to measure 5α-reductase activity in dermal papillae from miniaturized hair follicles of the human occipital scalp, revealing significant variability in enzyme activity across samples.
1 citations
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March 2019 in “KnE life sciences” This case report suggests that human dermal papillae conditioned media may accelerate wound healing in congenital aplasia cutis due to varicella infection.
September 2025 in “Journal of Dermatology Research and Therapy” In this study, two male patients with androgenetic alopecia who had previously undergone hair transplants showed increased hair regrowth after receiving verteporfin injections, with a 63% mean increase in dense donor sites, 38% in thinning areas, but no growth in bald areas.
September 2016 in “Journal of dermatological science” This study suggests that human induced pluripotent stem cells can be used to generate dermal papilla equivalent cells, potentially aiding hair follicle regeneration and drug discovery for hair diseases.
September 2024 in “Journal of Dental Specialities” This study found that platelet-rich plasma combined with micro-needling significantly increased hair density and thickness in patients with androgenetic alopecia, with mild side effects reported, though further high-quality trials are needed to validate these results and standardize treatments.
2 citations
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November 2019 in “FEBS open bio” This study found that stimulating dermal papilla cells with specific adipo-osteogenic factors and growth factors helped maintain their viability and restored their hair-forming activity in vitro.
5 citations
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August 2011 in “Biotechnology and Bioprocess Engineering”
17 citations
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May 2011 in “Gene Therapy” This study found that transfecting hair follicle stem cells with a PEI-DNA complex expressing hTERT stimulated hair growth in rats by inducing follicle neogenesis and promoting the anagen phase.
1 citations
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August 2017 This article reviews the mechanism, usage, and alternatives of the medication minoxidil in dermatology and reports no new clinical outcomes.
January 2026 in “Dermatologic Therapy” In this review, BTXA treatment was reported to effectively increase hair density and improve follicle health in androgenetic alopecia patients by enhancing scalp blood flow and reducing inflammation, without significant adverse effects.
July 2023 in “British journal of dermatology/British journal of dermatology, Supplement” This study investigated age-related changes in female scalp dermal fibroblasts, finding alterations in gene and protein expressions associated with fibrosis and senescence, which could potentially affect hair follicle health and contribute to aging-related hair changes.
1 citations
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March 2022 in “Protection convergence” This study found that double-fermented green coffee bean extracts displayed strong antioxidant, anti-inflammatory, and dermal papilla cell growth-promoting activities, suggesting potential use in cosmetics for scalp and hair health.
1 citations
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September 2021 in “Skin appendage disorders” This systematic review of five studies found that intradermal and intramuscular botulinum toxin injections showed promising hair growth outcomes for men with androgenic alopecia, but emphasizes caution due to a lack of control groups and small sample sizes.
April 2024 in “Journal of applied cosmetology” This review reported on botulinum toxin's potential in treating dermatological conditions like hidradenitis suppurativa, rosacea, androgenetic alopecia, plaque psoriasis, and primary hyperhidrosis, highlighting initial efficacy but indicating a need for controlled trials to confirm safety and effectiveness.
January 2008 in “Springer eBooks” Thyroid hormone may be useful for treating various skin conditions and needs more research.
113 citations
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July 2015 in “Journal of Cosmetic Dermatology” This review discusses the cosmetic applications of platelet-rich plasma in dermatology, highlighting its potential benefits and the need for more controlled studies.
12 citations
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May 2022 in “Plants” This review highlights the potential of nano-phytopharmaceuticals in improving the bioavailability and efficacy of phytochemicals for treating locomotor, dermal, reproductive, and urinary tract disorders, but notes that more clinical and preclinical research is needed to establish their safety and efficacy for human use.
November 2023 in “Materials Today Bio” This article discusses photobiomodulation as a potential adjunct to hair follicle organoid culture for androgenic alopecia, reporting no new results and suggesting further study is needed.
January 2022 in “Springer eBooks” This chapter reviews the clinical evidence of adding platelet-rich plasma to lipofilling for tissue regeneration, with suggestions of benefits in skin rejuvenation and wound healing, but lacks well-designed trials.
This study found that a fermented mixture containing Sasa Borealis leaf improved tensile strength and glossiness in hair damaged by heat perm and dyeing, suggesting potential as a cosmetic ingredient.
5 citations
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August 2019 in “Journal of The American Academy of Dermatology” This paper reviews the use of microneedling alone and in combination with platelet-rich plasma for various skin conditions, but it reports no new clinical findings.
29 citations
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September 2019 in “Stem Cells International” This study observed that a treatment combining platelet-rich fibrin and micrograft spray-on skin led to rapid and complete wound healing in both massive and chronic burn patients within an average of 7-10 days.
7 citations
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July 2015 in “Parasitology Research” This study found that the imidacloprid/flumethrin collar (Seresto®) is chemically compatible with major spot-on formulations and dermally and systemically safe for adult dogs and cats when used together.
November 2022 in “Regenerative Therapy” This review discusses various tissue engineering approaches for hair follicle regeneration and biomaterials used, emphasizing its potential despite current clinical challenges.
2 citations
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January 2021 in “Journal of Cosmetics, Dermatological Sciences and Applications” In this study, phenol-enriched olive mill wastewater extract positively influenced hair growth in vitro by promoting human dermal papilla cell proliferation, increasing insulin-like growth factor-1 secretion, and reducing reactive oxygen species, suggesting it may be beneficial for hair care.
May 2024 in “FEBS open bio” In this study, testing Annurca apple extract on human follicle dermal papilla cells indicated its potential to prevent patterned hair loss by reducing oxidative stress and increasing factors involved in hair growth.
January 2025 in “International Journal of Veterinary Science” In this animal study, hibiscus leaf simplicia ointment was found to protect red blood cell levels and promote better hair growth in UV-exposed rats, though it did not maintain normal skin histology; the ointment showed no significant acute dermal toxicity.