August 2023 in “Stem Cell Research & Therapy” A substance called Cell-free fat extract can effectively treat common hair loss by increasing hair growth and density.
March 2023 in “International Journal of Molecular Sciences” The study demonstrates that adipose mesenchymal stromal cell-derived exosomes (ADSC-Exos) carrying miR-122-5p can counteract the inhibitory effects of dihydrotestosterone (DHT) on hair follicles by targeting the TGF-β1/SMAD3 signaling pathway. ADSC-Exos promote hair follicle growth and dermal papilla cell (DPC) proliferation by down-regulating SMAD3, up-regulating β-catenin and versican, and restoring normal hair follicle function. These findings suggest that ADSC-Exos carrying miR-122-5p could be a promising treatment for androgenetic alopecia (AGA).
November 2022 in “Journal of Nanobiotechnology” This study developed a scalable and high-throughput method for producing an injectable composite system combining platelet-rich plasma (PRP), cell-laden microcarriers, and hydrogels for hair follicle (HF) tissue engineering. The system, tested both in vitro and in vivo, significantly enhanced dermal papilla cell (DPC) proliferation, migration, and HF regeneration. In vivo experiments on mice showed that PRP-loaded microcarriers accelerated hair cycle transition and increased new hair follicle formation, with ~35 HFs and ~12 vessels per site. The findings suggest that this composite system could be a promising approach for treating hair loss and promoting hair growth through sustained release of growth factors and a conducive microenvironment.
16 citations,
October 2015 in “Tissue Engineering Part C-methods” A two-step method was created in 2015 to make more cells that help with hair growth, but they need to be combined with other cells for 4 days to actually form new hair.
October 2023 in “Journal of Ethnopharmacology” The wild garlic plant, Allium macrostemon Bunge, can promote hair growth and could potentially be used to treat hair loss.
137 citations,
January 2006 in “Frontiers in bioscience” CRH in the skin acts like the body's stress response system, affecting cell behavior and immune activity.
1 citations,
September 2022 in “Evidence-based Complementary and Alternative Medicine” Gardenia florida fruit extract may help hair grow and needs more research to understand how.
34 citations,
June 2005 in “Developmental dynamics” Runx3 helps determine hair shape.
6 citations,
June 2022 in “Frontiers in Bioengineering and Biotechnology” The gel with icariin speeds up wound healing, reduces scarring, and helps hair growth by controlling BMP4 signaling. It also reduces inflammation and improves wound quality in mice, adapts to different wound shapes, and gradually releases icariin to aid healing. It also prevents too much collagen and myofibroblast formation during skin healing.
3 citations,
November 2022 in “International journal of molecular sciences” Bio-pulsed stimulation increases production of beneficial vesicles from bird stem cells that improve skin and hair cell functions.
3 citations,
March 2022 in “Polymers” Substances from Ascidian tunics might help treat hair loss as effectively as Minoxidil.
Justicia procumbens extract may help prevent hair loss and improve hair thickness and shine in a type of hair loss condition.
Arabica coffee pulp extract may help prevent hair loss and promote hair growth.
April 2023 in “Advanced functional materials” The study created a tool that mimics natural cell signals, which increased cell growth and could help with hair regeneration research.
180 citations,
January 2002 in “The journal of investigative dermatology/Journal of investigative dermatology” Vitamin D Receptor is crucial for normal skin and hair growth.
1 citations,
January 2024 in “International journal of molecular sciences” The research identifies genes linked to wool quality in sheep and provides insights to improve wool production.
1 citations,
April 2022 in “Regenerative Therapy” Activating the GDNF-GFRα1-RET signaling pathway could potentially promote skin and limb regeneration in humans and could be used to treat hair loss and promote wound healing.
26 citations,
January 2007 in “Organogenesis” Bioengineering can potentially treat hair loss by regenerating hair follicles and cloning hair, but the process is complex and needs more research.
214 citations,
April 2017 in “Cell” Different small areas within hair follicles send specific signals that control what type of cells stem cells become.
25 citations,
December 2007 in “Developmental biology” Clim proteins are essential for maintaining healthy corneas and hair follicles.
9 citations,
April 2009 in “The journal of investigative dermatology/Journal of investigative dermatology” Ectodysplasin signaling is crucial for skin appendage development, requiring specific doses and durations.
4 citations,
June 2022 in “BioMed Research International” Using mesenchymal stem cells or their exosomes is safe for COVID-19 patients and helps improve lung healing and oxygen levels.
March 2024 in “Advanced science” A new hydrogel made from human cells improves wound healing by working with immune cells to promote repair.
Regenerative cosmetics can improve skin and hair by reducing wrinkles, healing wounds, and promoting hair growth.
6 citations,
October 2019 in “Jo'jig gonghag gwa jaesaeng uihag/Tissue engineering and regenerative medicine” Rice bran extract boosts melanin production in hair follicles.
36 citations,
March 2011 in “Nature Communications” Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.
May 2018 in “Journal of Investigative Dermatology” Ginsenoside Rd may help improve skin aging by increasing collagen in the skin.
May 2018 in “Journal of Investigative Dermatology” Aging reduces skin cell renewal and defense against germs due to TGFbeta, but blocking TGFbeta could help restore these functions.
6 citations,
October 2021 in “Developmental biology” Dermal EZH2 controls skin cell development and hair growth in mice.
2 citations,
June 2021 in “Molecular Immunology” Dermal macrophages might help regrow hair.