150 citations,
April 2013 in “Dermato-endocrinology” Estrogen therapy can reduce skin aging but has cancer risks.
117 citations,
March 2017 in “Nature Communications” Macrophages help regrow hair by activating stem cells using AKT/β-catenin and TNF.
46 citations,
March 2015 in “Regeneration” Mice can grow new hair follicles after skin wounds through a process not involving existing hair stem cells, but requiring more research to understand fully.
10 citations,
October 2020 in “Frontiers in Cell and Developmental Biology” Wounds can regenerate hair in young mice, but this ability declines with age, offering insights for improving tissue regeneration in the elderly.
1 citations,
January 2021 CD4+ skin cells may be precursors to basal cell carcinoma.
408 citations,
January 2017 in “Science” Some wound-healing cells can turn into fat cells around new hair growth in mice.
156 citations,
October 2012 in “Seminars in Cell & Developmental Biology” Different types of stem cells in hair follicles play unique roles in wound healing and hair growth, with some stem cells not originating from existing hair follicles but from non-hair follicle cells. WNT signaling and the Lhx2 factor are key in creating new hair follicles.
151 citations,
November 2018 in “International Journal of Pharmaceutics” Nanoparticles improve drug delivery through the skin but more research is needed on their long-term effects and skin penetration challenges.
127 citations,
January 2015 in “Journal of Biological Rhythms” The skin's internal clock affects healing, cancer risk, aging, immunity, and hair growth, and disruptions can harm skin health.
58 citations,
January 2003 in “Thrombosis and Haemostasis” Testosterone may slow down wound healing and increase inflammation.
19 citations,
March 2018 in “Journal of Investigative Dermatology” The gene Msx2 is crucial for hair follicle regeneration during wound healing.
15 citations,
May 2015 in “Photomedicine and Laser Surgery” Low-Level Laser Therapy may help with flap survival and burn scar healing, but not with venous ulcers or hair loss, and more research is needed.
12 citations,
November 2020 in “Journal of Dermatological Science” Found microRNA differences in hair cells, suggesting potential treatment targets for hair loss.
7 citations,
August 2022 in “Nature communications” A specific group of slow-growing stem cells marked by Thy1 is crucial for skin maintenance and healing in mice.
2 citations,
November 2022 in “Scientific reports” Using gelatin sponges for deep skin wounds helps bone marrow cells repair tissue without scarring.
52 citations,
February 2012 in “PloS one” Lack of Ctip2 in skin cells delays wound healing and disrupts hair follicle stem cell markers in mice.
2 citations,
August 2023 in “Autophagy” Autophagy helps control skin inflammation and cancer responses and regulates hair growth by affecting stem cell activity.
29 citations,
January 2017 in “Journal of Investigative Dermatology” The Msi2 protein helps keep hair follicle stem cells inactive, controlling hair growth and regeneration.
3 citations,
April 2022 in “Frontiers in Physiology” Ptch2 plays a key role in controlling stem cell function and the ability to regenerate after birth.
2 citations,
December 2022 in “Pharmaceutics” The enzyme pyruvate kinase M2 helps hair regrowth and could be a potential treatment for hair loss.
2 citations,
September 2022 in “Frontiers in Immunology” T-regulatory cells are important for skin health and can affect hair growth and reduce skin inflammation.
5 citations,
October 2022 in “BMC genomics” Certain microRNAs are important for sheep hair follicle development and could help improve wool quality.
2 citations,
September 2023 in “International journal of molecular sciences” Special proteins are important for skin balance, healing, and aging, and affect skin stem cells.
February 2024 in “Bioengineering” The hydrogel made of chitosan, HPMC, and insulin speeds up wound healing and could be a new dressing, especially for diabetics.
1010 citations,
August 2000 in “Cell” Hair follicle stem cells can form both hair follicles and skin.
26 citations,
July 2021 in “Frontiers in Cell and Developmental Biology” The review suggests that a special cell-derived treatment shows promise for various skin conditions and hair growth but needs more research for confirmation.
7 citations,
February 2022 in “Stem cell reviews and reports” Skin cells show flexibility in healing wounds and forming tumors, with potential for treating hair disorders and chronic ulcers.
CyRL-QN15 peptide boosts hair growth in diabetic mice by activating specific cell pathways.
37 citations,
February 2019 in “Experimental Dermatology” Spiny mice are better at regenerating hair after injury than laboratory mice and could help us understand how to improve human skin repair.
291 citations,
April 2010 in “Gastroenterology” Certain proteins, Lgr5 and Lgr6, are important markers of adult stem cells and are involved in tissue repair and cancer development.