33 citations
,
January 2016 in “Skin appendage disorders” This review examines medical literature on postfinasteride syndrome and reports no new results; the authors call for more controlled studies on permanent sexual dysfunction and mood changes linked to 5-alpha-reductase inhibitors.
11 citations
,
September 2012 in “Journal of obstetrics and gynaecology Canada” This review examines the scientific evidence on the short-term safety of testosterone therapy for treating hypoactive sexual desire disorder in women, without presenting new clinical results.
22 citations
,
September 2018 in “Medical Clinics of North America” This article reviews the biological causes and treatment options for facial aging but reports no new clinical findings.
10 citations
,
October 2018 in “Sexual medicine reviews” This review discusses sexual side effects in men with androgenic alopecia treated with 5-alpha reductase inhibitors and reports no new clinical findings.
6 citations
,
April 2015 in “Behavioural Brain Research” In this study, finasteride was found to potentiate stress-induced disruption in sensory gating of rats by neutralizing the increase in allopregnanolone levels after acute stress.
May 2024 in “Deleted Journal” In this study, dutasteride was found to be effective and safe in treating androgenetic alopecia in men who did not respond to finasteride, with improvements observed in hair loss and quality over 24 weeks.
December 2023 in “International Journal of Biomedicine” In this review, researchers explored the potential of topical finasteride as an innovative treatment for male pattern hair loss, addressing the limitations of oral finasteride, such as side effects and inconsistent effectiveness.
January 2020 in “Archives of urology” This review discusses concerns about persistent side effects of finasteride, such as sexual dysfunction and suicidal ideation, urging the medical community to recognize and address these issues.
282 citations
,
October 2006 in “The Journal of Clinical Endocrinology and Metabolism” This review discusses guidelines for androgen use in women and concludes that more research is needed before recommending testosterone due to insufficient evidence on safety and efficacy.
35 citations
,
July 2015 in “Journal of Affective Disorders” This study found that women with polycystic ovary syndrome have significantly higher scores for affective temperaments and anxiety and depression than healthy controls, suggesting risk for depressive and anxiety disorders.
10 citations
,
April 2006 in “Seminars in Reproductive Medicine” This article reviews the limited evidence on testosterone therapy for premenopausal women and notes a lack of long-term safety and effectiveness data for this population.
1 citations
,
May 2015 in “Primary Health Care” This article discusses the classification of acne lesions and emphasizes the importance of evidence-based treatment and nursing care, without presenting new research results.
December 2018 in “Meandros medical and dental journal” This case study describes a male patient with very late-onset trichotillomania, highlighting the condition's potential association with comorbid depression.
815 citations
,
April 2010 in “The Journal of Clinical Endocrinology & Metabolism” This review examines the relationship between polycystic ovary syndrome and cardiovascular disease risk, but reports no new clinical findings; the panel calls for guidelines to prevent CVD in this population.
55 citations
,
July 1999 in “Clinics in Sports Medicine” This review discusses recent data on the use of anabolic-androgenic steroids and other steroid compounds and reports no new clinical results.
45 citations
,
July 2002 in “The Neurologist” This article reviews the challenges of using disease-modifying therapy for multiple sclerosis and offers strategies to improve treatment adherence and manage adverse effects, but reports no new clinical findings.
6 citations
,
August 2022 in “Molecules” This study indicates potential differences in the hair spectra of individuals with mood disorders, suggesting a promising, yet preliminary, method for noninvasive prediagnosis.
1 citations
,
January 2020 in “Journal of quality in health care & economics” This study found that while Sudanese women had good awareness of hormonal contraceptives, they lacked knowledge about emergency contraceptives and non-family planning benefits, with side effects like hair loss influencing their attitudes.
April 2026 in “Journal of Education Health and Sport” In this study, a literature review highlighted that anabolic-androgenic steroid use in physically active men is associated with adverse effects across multiple body systems, including cardiovascular, endocrine, and psychiatric complications, underscoring the need for increased clinical awareness and further research.
This narrative review concludes that long-term randomized controlled trials are needed to establish clear guidelines for testosterone therapy in women, given the lack of FDA-approved formulations and the variable quality of current treatments.
June 2020 in “Annals of the Rheumatic Diseases” This study surveyed patients with idiopathic inflammatory myopathy and found that glucocorticoid treatment commonly leads to adverse effects, particularly sleep disturbance, mood swings, and weight gain, with more severe effects reported by female patients.
August 2025 in “Annals of Indian Psychiatry” In a cross-sectional study, 46% of patients with androgenetic alopecia were found to have depression of borderline to moderate severity, while 62% reported no impact on their quality of life, emphasizing the need for awareness of psychiatric comorbidities among dermatologists.
1 citations
,
June 2024 in “Rehabilitation Medicine” This study found that higher levels of cortisol (F) and cortisone (E) in hair before stroke onset were significantly associated with post-stroke depression and anxiety, suggesting they could serve as potential predictors for these mood disorders.
1 citations
,
March 2023 in “Scientific Reports” This cohort study found no overall increased risk of suicidal behaviors with finasteride versus dutasteride in men aged 50 and older, but suggested potential risk for those with a history of mood disorders.
2 citations
,
December 2021 in “International Journal of Andrology” This review of legal cases found that 5α-reductase inhibitors, alleged to cause sexual, mental, and physical side effects, have led to numerous lawsuits with increasing litigation expected in the future.
156 citations
,
August 2014 in “Cochrane library” This study suggests that oral budesonide may not effectively maintain remission in Crohn's disease beyond three months, with minor benefits that are outweighed by increased rates of treatment-related adverse events.
3 citations
,
May 2021 in “PloS one” This study found that Jordanian males use oral contraceptive pills, particularly for bodybuilding, based on recommendations from gym coaches, highlighting unexpected uses of these medications.
April 2026 in “Brain Sciences” This pharmacovigilance study analyzed FAERS data and found that finasteride is more frequently associated with neuropsychiatric reactions like depression and suicide risk, especially in younger men using it for alopecia, compared to dutasteride.
20 citations
,
January 2003 in “Treatments in Endocrinology” Testosterone therapy can help improve mood, sexual function, and bone health in women with low androgen levels, but more research is needed to establish safe and effective guidelines.
4 citations
,
March 2002 in “International journal of toxicology” In this study on tolerant rats, maternal and developmental toxicity from levo-alpha-acetyhnethadol hydrochloride were observed at all doses, without specific fetal toxicity or teratogenic effects.