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The review suggests that while many AKR1C3 inhibitors show promise for treating certain cancers, more research is needed to confirm their effectiveness in humans.

There are various effective hormone treatments for puberty induction in boys and girls with hypogonadism, and starting treatment early is important.

Australian doctors experienced in adult transgender healthcare mostly prescribe intramuscular testosterone and oral estradiol, recommend mental health assessments before hormone therapy, and support improved training and guidelines.

The guideline recommends mental health involvement in diagnosing gender identity disorder and outlines hormone and surgical treatment protocols, emphasizing safety, informed consent, and long-term monitoring.

The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.

Cross-sex hormone therapy is important for managing gender dysphoria and requires careful monitoring and healthcare provider education.

The document concludes that early diagnosis and treatment of PCOS in teenagers is important for managing symptoms and preventing long-term health problems.

Microneedles are promising for long-acting drug delivery and can improve patient compliance, but more data is needed to confirm their effectiveness.

Early medical support for transgender youth is important for their health, with low regret for gender-affirming hormone use and a need for knowledgeable care providers.

Certain medications can reduce sexual desire and function, especially in women.

Primary care is key in managing PCOS, focusing on lifestyle changes and medications like birth control and metformin.

Antiandrogens and androgen inhibitors like spironolactone, finasteride, and dutasteride can treat hair loss and skin conditions, but they have risks and side effects, including potential harm to pregnant women and risks of cancer and heart issues. Herbal remedies also have antiandrogenic effects but lack safety validation.

The conclusion is that young women with excessive hair growth should be quickly tested for hormonal issues and treated to improve their social well-being.

Hormonal imbalances can cause skin and hair problems in women, and treatments that block male hormones can help.

The European Society of Endocrinology advises individualized long-term management for PCOS, focusing on lifestyle changes, accurate diagnosis, and treatments for associated health risks and symptoms.

Lower doses of treatments for hirsutism and acne in PCOS are effective and cause fewer side effects.

Early diagnosis and individualized treatment improve outcomes for Congenital Adrenal Hyperplasia.

Hormone therapy is essential for transgender individuals but requires careful management due to possible metabolic effects.

Antiandrogens have important biological effects, but more research is needed to understand them fully and compare their effectiveness and side effects to other treatments.

The document concludes that individualized treatment and lifestyle changes are important for managing menopause symptoms and health risks.

Androgen replacement therapy can improve libido and mood in women with severe androgen deficiency, but more research is needed on its long-term safety.

Sex hormones affect reproduction, sexual development, and oral health, and it's important for dental practitioners to understand their effects and interactions.

Genetic mutations can affect female sexual development, requiring personalized medical care.

The document concludes that early recognition and treatment of PCOS in adolescents is crucial for managing symptoms and long-term health risks.

The right dosage of CPA and TB can work as a safe and reversible male contraceptive in monkeys.

The NAMS 2014 recommendations guide healthcare providers on treating health issues in midlife women, emphasizing individualized care and informed decision-making.

Pediatric dermatologists need to understand the unique skin health needs of LGBTQIA youth to provide better care.

Hormonal imbalances are a key cause of missed menstrual periods in women.

Many women experience sexual dysfunction, but few seek help, and better treatment and medical training are needed.

Decursin shows promise for treating cancer, neuroprotection, inflammation, and hair loss.