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This review discusses recent advancements in developing delivery systems for small interfering RNA (siRNA) to treat skin conditions, highlighting innovations like liposomes, dendrimers, cell-penetrating peptides, and spherical nucleic acid nanoparticles designed to overcome challenges of skin permeability and degradation.

This study highlights the promise of nanoparticles in cancer treatment, addressing limitations of conventional chemotherapy such as drug resistance and toxicity, by using nanocarriers like gold nanoparticles and dendrimers to improve drug delivery.

This study outlines new strategies for overcoming "cold" tumors, which are typically unresponsive to cancer immunotherapy, with approaches like dendritic cell-based treatments and local immune microenvironment modification, bolstered by both preclinical and clinical trial data.

This article in Experimental Dermatology does not include an abstract or any new research findings.

Some cells may slow melanoma growth, a protein could affect skin pigmentation, a gene-silencing method might treat hair defects, skin bacteria changes likely result from eczema, and a defensin protein could help treat multiple sclerosis.

This study observed that during male silkmoth development, trichogen cells in olfactory sensilla undergo significant membrane recycling, contributing to sensillum structure formation in a precisely timed series of stages.

This study used atomic force microscopy to image surface structures of human epidermal melanocytes, hair follicle amelanotic melanocytes, and mouse melanoma cells, revealing differences in branch structure and granule distribution.

This study reports that treatment with X-rays or procarbazine induced dose-dependent mutations in melanocytes in mouse hair follicles, showing similar mutation rates to previous methods.

This review explores the multifaceted roles of melanocytes in skin biology, emphasizing their potential impact on future research to prevent and treat skin diseases, but reports no new experimental results.

This research discusses potential cancer vaccine strategies using cell-based and DNA vector-based approaches, and suggests targeting the v3 splice variant of thioredoxin reductase 1 to inhibit cancer cell motility and metastasis formation.

In this study, nestin-expressing cells in the hair follicle bulge, marked by GFP in transgenic mice, were identified as progenitors of the hair follicle outer-root sheath.

This study concluded that combining cyanoacrylate skin surface stripping with particle-based antigen delivery effectively targets HIV-1 p24 protein to skin cells, supporting its potential for needle-free transcutaneous vaccination.

In this study, Epimedii Folium extract was found to enhance melanin production and promote pigmentation through mechanisms involving the MAPK/ERK1/2 pathway in both in vitro and in vivo models.

This study characterized the inflammatory response in a murine burn model, revealing similarities to human burns and supporting the model's use in testing therapies for burn complications.

In this study, single-cell sequencing revealed clonal expansions of CD4+ and CD8+ T cells in murine and human alopecia areata, supporting the development of predictive models for human disease.

In this study, the authors concluded that androgens, but not estrogens, strictly mediate the maintenance of neuromuscular morphology in the spinal nucleus of the bulbocavernosus in adult rats.

This review discusses how polymer-based nanocarriers can enhance drug delivery targeting hair follicles for acne treatment, focusing on factors affecting this delivery method, combination technologies to improve follicle targeting, and recent advancements in polymer nanodrug-delivery systems.

This review discusses the regulation of myeloid cell networks in barrier tissues and how various factors influence immune homeostasis, but it reports no new experimental results.

In this study, researchers used advanced techniques to map the early embryonic development of mouse skin, identifying diverse cell populations and uncovering complex interactions essential for skin structure, signaling, and function.

This study found distinct localization patterns of S100 family proteins in hair follicles, suggesting their differential roles in normal hair follicle physiology.

This study demonstrated that ablation of individual somatostatin-expressing interneurons increased activity in nearby neurons of the mouse motor cortex during motor learning.

This perspective reviews current knowledge about cellular and molecular mechanisms in wound healing from 2023–2025, highlighting inadequately understood pathways associated with conditions like keloids and chronic wounds, and discusses proposed novel therapies for these conditions.

This article discusses how designing biomaterials to modulate immune responses has become a promising strategy for enhancing tissue repair and regeneration.

This study found that 62 plasma proteins are significantly associated with the risk of obstructive sleep apnea, offering potential targets for new therapeutic strategies.

This study reported that the coat hairs of golden takin, living in harsh environments, have unique structural features compared to cattle, with overcoat hairs having continuous medullated tissue and undercoat hairs being finely crimped, potentially contributing to temperature regulation in cold conditions.

Certain immune cells are linked to non-scarring hair loss, suggesting potential for immune-targeted treatments.

This review compiles the anatomical, histological, and physiological characteristics of various human body follicles, highlighting potential avenues for future research, but does not report new clinical results.

Hair shaft miniaturization leads to hair follicle stem cell loss, suggesting Piezo1 as a potential treatment target.

This study found that multicomponent microarray patches for SARS-CoV-2 vaccination produced stronger immune responses and fewer side effects in mice compared to traditional intramuscular injection.

This study identifies a mechanism where dsRNA activates TLR3 to induce RA production, promoting hair follicle regeneration in mice and suggesting a potential role in human tissue regeneration.