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New treatments for male hypogonadism are effective and should be personalized.

The document concludes that proper diagnosis and FDA-approved treatments for different types of hair loss exist, but treatments for severe cases often fail and future improvements may focus on hair follicle stem cells.

Women with PCOS often have skin problems like excessive hair, acne, hair loss, and dark patches, which can be treated with hormonal and non-hormonal therapies.

Targeting the skin's endocannabinoid system could help treat skin disorders.

Some treatments, like corticosteroids and sensitizing agents, can help with alopecia areata, but more high-quality research is needed.

Wnt signaling is crucial for skin and hair development and its disruption can cause skin tumors.

Exosomes from dermal papilla cells help hair growth by making hair follicle stem cells multiply and change.

New genes and pathways are important for testosterone production and male sexual development.

Keratin proteins are crucial for healthy skin, but mutations can cause skin disorders with no effective treatments yet.

Finasteride reduces hairiness and androgen levels in women with unexplained excessive hair growth.

The FOXN1 gene is crucial for developing immune cells and preventing immune disorders.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

Prostaglandin D2 blocks new hair growth after skin injury through the Gpr44 receptor.

Some breast cancer chemotherapy can cause permanent hair loss.

The document concludes that for hair and feather growth, it's better to target the environment around stem cells than the cells themselves.

Skin fat has important roles in hair growth, skin repair, immune defense, and aging, and could be targeted for skin and hair treatments.

Toll-like receptors are important for wound healing, but can slow it down in diabetic wounds.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

Hair sensitivity to androgens is partly controlled by specific enzyme expressions in different hair areas.

LED therapy is safe and shows potential for treating skin conditions and promoting hair growth, but more research is needed.

PRP more effective than minoxidil 5% for treating alopecia areata.

Low iron and vitamin D levels are linked to hair loss in women.

A second domain of high sulfur KAP genes on chromosome 21q23 is crucial for hair structure.

There is no clear recommendation for using selenium in cancer patients; it may be beneficial to correct low selenium levels before treatment.

PPAR agonists show promise for skin conditions but need more research before being a main treatment.

Certain signals and genes play a key role in hair growth and regeneration, and understanding these could lead to new treatments for skin regeneration.

Fadrozole and finasteride change gene expression related to sex hormones and thyroid hormones in frog larvae development.

Both drugs lower DHT levels, with GI198745 being more effective.

ZDHHC13 is important for normal liver function and metabolism, affecting mitochondrial activity.

Environmental factors at different levels control hair stem cell activity, which could lead to new hair growth and alopecia treatments.