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Animal models have helped understand hair loss from alopecia areata and find new treatments.

Nuclear hormone receptors play a significant role in skin wound healing and could lead to better treatment methods.

TGFβ's manipulation of inflammation and immune cells affects cancer spread, suggesting new treatment strategies and biomarkers.

Mice can grow new hair follicles after skin wounds through a process not involving existing hair stem cells, but requiring more research to understand fully.

Signaling pathways are crucial for hair growth in goats.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Benzothiazepines like diltiazem reduce anxiety in mice by making neurosteroids.

Alopecia areata is an autoimmune condition causing hair loss, linked to genetic factors and immune system issues, with no cure yet.

Mice without the vitamin D receptor have bone issues and other health problems, suggesting vitamin D is important for preventing various diseases in humans.

The document concludes that better targeted treatments are needed for wound healing, and single-cell technologies may improve cell-based therapies.

Changing the environment around stem cells could help tissue repair, but it's hard to be precise and avoid side effects.

Hair follicle development is controlled by interactions between skin tissues and specific molecular signals.

Some wound-healing cells can turn into fat cells around new hair growth in mice.

Stem cell niches are crucial for regulating stem cell behavior and tissue health, and their decline can impact aging and cancer.

The skin has a complex immune system that is essential for protection and healing, requiring more research for better wound treatment.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

Growing human skin cells in a 3D environment can stimulate new hair growth.

Stem cell offspring help control their parent stem cells, affecting tissue health, healing, and cancer.

TGF-β is crucial for tissue repair and can cause diseases if not properly regulated.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

Stem cell niches are crucial for regulating stem cell renewal and differentiation, and understanding them can help in developing regenerative therapies.

Hair follicle development and microbes help regulatory T cells gather in newborn skin.

Epidermal stem cells are diverse and vary in activity, playing key roles in skin maintenance and repair.

Stem cell niches support, regulate, and coordinate stem cell functions.

Estrogens significantly influence hair growth by interacting with receptors in hair follicles and may help regulate the hair growth cycle.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Alopecia areata is an autoimmune disease causing patchy hair loss, often with other autoimmune disorders, but its exact causes are unknown.

Protoporphyrin IX is useful in cancer treatment but can cause health problems if not properly regulated.

Eating less sugar, milk, and saturated fats and more vegetables and fish may help treat and prevent acne.

Different types of stem cells with unique roles exist in blood, skin, and intestines, and this variety is important for tissue repair.