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Genetic defects in testosterone production can cause hormonal and developmental disorders, and more research is needed to understand androgen regulation and develop safer treatments.

New genes and pathways are important for testosterone production and male sexual development.

Androgens like testosterone are important hormones for both men and women, made differently in each sex and affecting the body by regulating genes and quick interactions with cell components.

The document explains how male reproductive hormones work and affect the body.

Diet changes hormone levels in pregnant ewes by affecting metabolism, not placental synthesis.

Dihydrotestosterone can be made from dehydroepiandrosterone in skin cells without needing testosterone.

Lymphatic vessels are essential for health and can be targeted to treat various diseases.

Mice without the enzyme HSD17B3 still produce normal testosterone, suggesting they have different ways to make it compared to humans.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Mutations in Plcd1 and Plcd3 together cause severe hair loss in mice.

Testosterone may worsen hair loss by affecting hair growth signals, while different prostaglandins can either hinder or promote hair growth.

Testosterone can both promote hair growth and cause baldness by affecting hair growth signals.

Researchers found four key stages of cell development that are important for hair growth and shedding in cashmere goats.

Anti-acne medications may work by reducing the activity of a protein involved in acne development.

The document concludes that inflammation markers can be used in diabetes, vitamin D3 affects immune pathways, hyperthyroidism changes hormone levels, androgen levels help diagnose Adrenocortical Carcinoma, erectile dysfunction is linked to diabetes, hypogonadism is common in HIV-infected males, and hormones can be biomarkers for various conditions.

The document concludes that blocking the internal pathways that create androgens might help treat cancers that depend on sex hormones.

Finasteride may lower cholesterol and slow heart disease progression.

Increased FGFR2b signaling, influenced by androgens, plays a role in causing acne.

People with hair loss have more androgen receptors and enzymes in certain follicles, with men and women showing different patterns.

Men with baldness have higher levels of specific proteins, suggesting local hormone production may play a role in hair loss.

Hair loss, known as Androgenetic Alopecia, is often caused by hormones and can be diagnosed using noninvasive techniques. Treatments include topical minoxidil and oral finasteride, with new treatments being explored. There may also be a link between this type of hair loss and heart disease risk.

New treatments for male hypogonadism are effective and should be personalized.

The document concludes that more research is needed to fully understand the causes of PCOS.

Avicennia Marina extract and avicequinone C can reduce hair loss hormone production and increase hair growth factors, suggesting they could be used to treat androgenic alopecia.

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

Some breast cancer chemotherapy can cause permanent hair loss.

The enzymes 5α-reductase and 3α/β-hydroxysteroid oxidoreductase help create brain-active substances from progesterone and testosterone, which could be used for treatment, but more research is needed to ensure their safety and effectiveness.

Drugs for hormone-related conditions might help treat mental disorders but could have serious side effects.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.