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Congenital Adrenal Hyperplasia is a genetic disorder with two forms, causing symptoms like early puberty and severe acne, but can be identified through screening and treated with glucocorticoids.

The document concludes that more research is needed to better understand and treat primary cicatricial alopecias, and suggests a possible reclassification based on molecular pathways.

Palliative chemotherapy is cost-effective for advanced gastric and colorectal cancer but not clearly for pancreatic-biliary cancer.

Women with PCOS have overall higher body fat, not abnormal fat placement, and more insulin resistance.

Cancer cells often have more copies of TERT and TERC genes, which helps them grow and could affect patient outcomes.

The WNT signaling pathway is important in many diseases and targeting it could offer new treatments.

Postpartum depression is linked to changes in brain chemicals, inflammation, stress, and certain genes, and can potentially be identified by markers like specific steroids, serotonin levels, and vitamin D levels.

RNAi-based biopesticides could be safe and effective for pest control with careful development and risk assessment.

Liposomes improve drug delivery and reduce skin irritation in dermatology.

Transplant success has improved with better immunosuppressive drugs and donor matching.

Sonic hedgehog signaling is crucial for hair growth and maintaining hair follicle identity.

PRP treatment helps hair growth and density in androgenetic alopecia patients.

Antibiotics can reduce acne but may lead to resistant bacteria, and understanding the skin's bacteria is important for treatment.

Facial feminization surgery is effective in helping transgender women appear more feminine and has high patient satisfaction.

Microneedles help improve skin appearance and deliver skin treatments effectively, but safety concerns need more research and regulation.

PEVs improve minoxidil skin penetration, increasing hair growth.

Surgery is the main treatment for liver hydatidosis, but has risks; albendazole is the most effective drug but can have side effects.

Foxp3 is crucial for regulatory T cell function, and targeting these cells may help treat immune disorders.

TRP channels in the skin are important for sensation and health, and targeting them could help treat skin disorders.

No single treatment is consistently effective for alopecia areata, and more research is needed.

Hibiscus plant extracts may have health benefits like lowering blood pressure and protecting the heart.

Women with PCOS and higher androgen levels are more likely to have fatty liver disease.

The update highlights that non-classic congenital adrenal hyperplasia is common in women with excess male hormones, requires specific hormone tests for diagnosis, and has various treatment options depending on age and symptoms.

Adult female acne treatment should be personalized, considering individual preferences and pregnancy, using various topical and oral medications while managing side effects and resistance.

TSH is usually the only test needed to check thyroid function in primary care.

People with PCOS, especially if obese, often have NAFLD, linked to obesity, insulin resistance, and high androgen levels.

Animals that change color with the seasons mainly do so in response to daylight changes, but climate change is causing camouflage problems that may require evolutionary changes.

New topical antifungals and delivery systems are improving treatment for fungal skin infections, but patient education and prevention are key.

Lignans and neolignans from plants may help protect against various health issues, including cancer and heart disease.

Blocking the Wnt pathway could lead to new treatments for cancer and tissue repair but requires careful development to avoid side effects.