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GlossaryDifferentially Expressed Genes (DEGs)

genes showing varied activity levels under different conditions

Differentially Expressed Genes (DEGs) are genes that show different levels of expression in different conditions, such as between healthy and diseased tissues. For example, in the context of alopecia, DEGs might be identified by comparing gene activity in hair follicles from individuals with alopecia to those without, helping researchers understand the molecular mechanisms underlying the condition.

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research Microarray Analysis of Androgenetic and Senescent Alopecia: Comparison of Gene Expression Shows Two Distinct Profiles

27 citations, November 2013 in “Journal of Dermatological Science”

The conclusion is that androgenetic alopecia and senescent alopecia have unique gene changes, suggesting different causes and potential treatments for these hair loss types.

research Comparative Study on Seasonal Hair Follicle Cycling by Analysis of the Transcriptomes from Cashmere and Milk Goats

25 citations, February 2019 in “Genomics”

Cashmere and milk goats have different hair growth cycles and gene expressions, which could help improve wool production.

research Transcriptomic Analysis Reveals Critical Genes for the Hair Follicle of Inner Mongolia Cashmere Goat from Catagen to Telogen

25 citations, October 2018 in “PloS one”

Key genes regulate hair follicle phase changes in Inner Mongolia cashmere goats.

research Hidradenitis Suppurativa and Comorbid Disorder Biomarkers, Druggable Genes, New Drugs and Drug Repurposing—A Molecular Meta-Analysis

15 citations, December 2021 in “Pharmaceutics”

The study found key factors in the cause of hidradenitis suppurativa, its link to other diseases, and identified existing drugs that could potentially treat it.

research Gene Network Analysis Reveals Candidate Genes Related to Hair Follicle Development in Sheep

14 citations, June 2022 in “BMC genomics”

Key genes crucial for sheep hair follicle development were identified, aiding fine wool breeding and human hair loss research.

Transcriptomic Inspection Revealed a Possible Pathway Regulating the Formation of the High-Quality Brush Hair in Chinese Haimen Goat (Capra Hircus)

research Transcriptomic Inspection Revealed a Possible Pathway Regulating the Formation of the High-Quality Brush Hair in Chinese Haimen Goat (Capra Hircus)

11 citations, January 2018 in “Royal Society Open Science”

Scientists found genes linked to the growth of high-quality brush hair in Chinese Haimen goats.

research Differential Expression Patterns of Specific Long Noncoding RNAs and Competing Endogenous RNA Network in Alopecia Areata

10 citations, February 2019 in “Journal of Cellular Biochemistry”

Specific RNA patterns are linked to alopecia areata.

research RNA Sequence Analysis of Dermal Papilla Cells’ Regeneration in 3D Culture

6 citations, October 2020 in “Journal of Cellular and Molecular Medicine”

3D culture helps maintain hair growth cells better than 2D culture and identifies key genes for potential hair loss treatments.

In Silico Analysis of Gene Expression Data from Bald Frontal and Haired Occipital Scalp to Identify Candidate Genes in Male Androgenetic Alopecia

research In Silico Analysis of Gene Expression Data from Bald Frontal and Haired Occipital Scalp to Identify Candidate Genes in Male Androgenetic Alopecia

6 citations, September 2019 in “Archives of Dermatological Research”

Found 32 genes linked to male baldness, affecting hair growth and stress-related pathways.

research Discovery of Differentially Expressed Genes in Cashmere Goat Hair Follicles by RNA Sequencing

5 citations, January 2016 in “Genetics and Molecular Research”

Researchers found 617 genes that behave differently in cashmere goat hair follicles, which could help understand hair growth.

Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms

research Construction of Regulatory Network for Alopecia Areata Progression and Identification of Immune Monitoring Genes Based on Multiple Machine-Learning Algorithms

3 citations, May 2023 in “Precision clinical medicine”

Researchers found four genes that could help diagnose severe alopecia areata early.

research Enrichment of Specific Hair Follicle-Associated Cell Populations in Plucked Hairs Offers an Opportunity to Study Gene Expression Underlying Hair Traits

2 citations, December 2022 in “International journal of molecular sciences”

Plucked hairs can be used instead of skin biopsies to study hair traits because they contain specific cells related to hair.

research Genomic and Transcriptomic Characterization of Atypical Recurrent Flank Alopecia in the Cesky Fousek

2 citations, April 2022 in “Genes”

The study found that the hair loss condition in Cesky Fousek dogs is influenced by multiple genes affecting skin and muscle structure, fat metabolism, and immunity.

research Identification of Key Genes in Type 2 Diabetes-Induced Erectile Dysfunction Rats with Stem Cell Therapy Through High-Throughput Sequencing and Bioinformatic Analysis

2 citations, March 2021 in “Andrologia”

Stem cell therapy affects 15 key genes in rats with diabetes-related erectile dysfunction.

research Pathway Enrichment and Network Analysis of Differentially Expressed Genes in Pashmina Goat

1 citations, June 2022 in “Gene reports”

The analysis found genes linked to skin and hair development are more active in Pashmina goats, which may explain their long-fiber production.

research Whole Blood Transcriptome Profiling Identifies Candidate Genes Associated With Alopecia in Male Giant Pandas

1 citations, April 2022 in “BMC Genomics”

Researchers found genes linked to hair loss in male giant pandas.

research Investigation of Transcriptional Gene Profiling in Normal Murine Hair Follicular Substructures Using Next-Generation Sequencing to Provide Potential Insights into Skin Disease

1 citations, February 2016 in “Cell Transplantation”

Hair follicles have a more inactive cell cycle than other skin cells, which may help develop targeted therapies for skin diseases and cancer.

research Comprehensive Transcriptome Profiling Between Balding and Non-Balding Scalp of Female Pattern Hair Loss in Asian

June 2024 in “Archives of Dermatological Research”

SFRP2 and PTGDS may be key factors in female hair loss.

Transcriptome Sequencing and Mass Spectrometry Reveal Genes Involved in Non-Mendelian Inheritance-Mediated Feather Growth Rate in Chickens

research Transcriptome Sequencing and Mass Spectrometry Reveal Genes Involved in Non-Mendelian Inheritance-Mediated Feather Growth Rate in Chickens

January 2024 in “Biochemical genetics”

The research found specific genes and proteins that affect how fast chickens' feathers grow, which is not solely determined by traditional inheritance patterns.

research Identification of Potential miRNA–mRNA Regulatory Network Associated with Growth and Development of Hair Follicles in Forest Musk Deer

December 2023 in “Animals”

The research found genes and miRNAs that may control hair growth in Forest Musk Deer.

research Adipose Transcriptome in the Scalp of Androgenetic Alopecia

September 2023 in “Frontiers in Medicine”

The scalp fat tissue of men with hair loss shows changes in gene activity that may contribute to their condition.

Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats

research Transcriptomic Analysis Reveals Candidate Ligand-Receptor Pairs and Signaling Networks Mediating Intercellular Communication between Hair Matrix Cells and Dermal Papilla Cells from Cashmere Goats

June 2023 in “Cells”

The research identified key molecules that help hair matrix and dermal papilla cells communicate and influence hair growth in cashmere goats.

Bioinformatic Analysis of Gene Expression Data Reveals Src Family Protein Tyrosine Kinases as Key Players in Androgenetic Alopecia

research Bioinformatic Analysis of Gene Expression Data Reveals Src Family Protein Tyrosine Kinases as Key Players in Androgenetic Alopecia

June 2023 in “Frontiers in Medicine”

Protein tyrosine kinases are key in male pattern baldness, affecting skin structure, hair growth, and immune responses.

research Assessment of Dysregulation of HERC6 and Essential Biological Processes in Response to Laser Therapy of Human Arm Skin

March 2020 in “Journal of lasers in medical sciences”

Laser therapy on human skin affects the HERC6 gene and related genes, influencing many cell processes and requiring careful safety measures.

research Exploring Differentially Expressed Genes by RNA-Seq in Cashmere Goat Skin During Hair Follicle Development and Cycling

61 citations, April 2013 in “PloS one”

The study found key genes and pathways involved in cashmere goat hair growth stages.

research Transcriptome Analysis of Frontal Fibrosing Alopecia Revealed Involvement of Immune Cells and Ferroptosis

February 2024 in “Skin research and technology”

The research suggests that immune cells and a specific type of cell death called ferroptosis are involved in Frontal fibrosis alopecia.

Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures

research Transcriptional Profiling in Alopecia Areata Defines Immune and Cell Cycle Control Related Genes Within Disease-Specific Signatures

61 citations, September 2010 in “Genomics”

The study found that immune responses disrupt hair growth cycles, causing hair loss in alopecia areata.