October 2023 in “Journal of Advanced Sciences” This review highlights PRF's potential as a regenerative medicine tool, detailing its diverse applications in dentistry, orthopedics, and dermatology, but presents no new clinical results.
24 citations
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October 2024 in “International Journal of Extreme Manufacturing” This review discusses the advancements and challenges in skin bioprinting techniques and applications, including hair follicles and pigmentation, while addressing the need for improvements in vascularization, safety, and clinical translation, according to the authors.
5 citations
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May 2024 in “BMC Biotechnology” This study found that using three-dimensional cell culture with Matrigel enhances the biological function and stemness of stem cells, leading to improved soft tissue repair and healing by activating the host microenvironment and autologous stem cells.
5 citations
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July 2023 in “Frontiers in Veterinary Science” This study found that wounds in sheep treated with mesenchymal stem cells and platelet-rich plasma showed improved healing, reduced inflammation and contraction, and better skin structure compared to untreated wounds.
143 citations
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September 2008 in “Experimental gerontology” This review discusses the diverse roles and characteristics of epidermal and dermal stem cells in skin regeneration and aging, highlighting their potential applications in regenerative medicine and reports no new clinical results.
In this study, researchers observed that during zebrafish fin regeneration, osteoblast Erk activity, influenced by Fgf receptor signaling, forms gradients scaling with amputation length, which predicts regenerative tissue growth and skeletal structure size.
January 2025 in “PLoS ONE” This study identified the transcription factor Elf5 as a novel regulator of keratinocyte proliferation and differentiation in skin, with expression elevated in stem/progenitor cell populations, suggesting its potential role in determining cell fate during skin and hair development.
May 2025 in “Ambulatornaya khirurgiya = Ambulatory Surgery (Russia)” This study found that using platelet-rich plasma in optimal doses improves mesh integration and reduces the risk of chronic pain and fibrosis in hernia repair, but overdoses led to inflammatory complications in rats.
121 citations
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March 1989 in “Journal of Investigative Dermatology” Minoxidil can help grow hair in mice by making cells grow and improving hair quality. More research needed.
1 citations
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February 2004 in “Medical Hypotheses” This article reviews the theory that certain cultural practices, like specific haircuts, contribute to common baldness but reports no new clinical findings.
April 2026 in “International Journal of Molecular Sciences” This review synthesizes recent research on how Wnt signaling regulates skin, hair follicle, and nail regeneration, highlighting its compartment-specific roles and discussing targeted strategies for treating conditions like alopecia, chronic wounds, and skin cancer.
44 citations
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January 2018 in “The International Journal of Developmental Biology” This review discusses the role and plasticity of epidermal stem cells in skin maintenance, wound repair, and cancer, noting recent insights from advanced technologies but providing no new clinical results.
February 2023 in “Materials Express” This study demonstrated that pine pollen extract may enhance wound healing by promoting antioxidant and anti-inflammatory activity, collagen formation, and tissue regeneration, particularly at a concentration of 1 mg/mL.
10 citations
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July 2011 in “Wound Repair and Regeneration” This article proposes several potential approaches for scar prevention and therapy, including anti-transforming growth factor-β strategies and tissue-engineered skin, but reports no new clinical results.
October 2025 in “International Journal of Nutrology” This systematic review found that exosomes and gut microbiota play a significant role in skin regenerative processes, suggesting that gut health is crucial for maintaining aesthetically healthy skin, and probiotic treatments may support traditional dermatological therapies for inflammatory skin diseases.
January 2008 in “Summit (Simon Fraser University)” This article describes viDA Therapeutics Inc.'s focus on developing new drugs for age-related conditions using their proprietary granzyme-based approach but reports no clinical outcomes, primarily discussing their funding and business strategy.
41 citations
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July 2019 in “Clinical Cosmetic and Investigational Dermatology” This paper explores the complex immune processes and cellular diversity that enable the skin to heal and resist invasion, and highlights its potential as a model for studying regeneration.
September 2025 in “Medicine Today and Tomorrow” This analysis reported that exosomes and growth factors show promise in dermatology by activating skin regeneration processes, aiding conditions like atopic dermatitis and hyperpigmentation, though further research is needed to establish standardized protocols and assess long-term effects.
July 2026 in “Cell Communication and Signaling” This review discusses the aging process of hair follicle stem cells and their niche, focusing on degradation mechanisms and potential therapeutic strategies, but it reports no new results.
August 2026 in “Journal of Personalized Medicine” This narrative review proposes the concept of "repigmentation competence" for vitiligo lesions, suggesting that therapy responses are influenced by lesion-specific biological factors related to immune, regenerative, regulatory, and microenvironmental processes, and highlights the emerging role of combination therapies targeting these pathways.
127 citations
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December 2007 in “Journal of Investigative Dermatology” This review examines regenerative hair waves and complex hair cycle domains in transgenic mice, highlighting how these dynamic processes contribute to skin regeneration and the physiological regulation of organs, but reports no new experimental results.
1 citations
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April 2022 in “Regenerative Therapy” This study suggests that the GDNF signaling pathway may enhance skin regeneration, as observed in axolotls and Spiny mice, indicating potential for similar processes in humans.
June 2026 in “THE THERAPIST (Journal of Therapies & Rehabilitation Sciences)” This review highlights the rising interest in exosomes within regenerative medicine, emphasizing their role as communicators that offer standardized manufacturing and ease of use over stem cells. Yet, exosomes complement rather than replace stem cells, each holding unique positions within biological processes.
2 citations
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July 2021 in “Biochemical and Biophysical Research Communications” This study found that plantar dermis matrix homogenate can partially restore the regenerative capacity of hair follicles impaired in culture, with CTHRC1 playing a critical role in this process.
September 2022 in “bioRxiv (Cold Spring Harbor Laboratory)” This study indicates that a helminth-derived protein, TGF-β mimic, may accelerate wound healing and promote regenerative processes in skin tissue by interacting with TGF-β receptors.
36 citations
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October 2023 in “Periodontology 2000” This narrative review concluded that autologous platelet concentrates, particularly L-PRF, effectively enhance bone and soft tissue healing in periodontal regenerative procedures, with L-PRF demonstrating the most convincing results and ease of use.
July 2026 in “Zenodo (CERN European Organization for Nuclear Research)” This review discusses the process and benefits of Platelet-Rich Plasma therapy for hair restoration, emphasizing its safety and potential for encouraging hair growth, but reports no new clinical results.
October 2023 in “Oncotarget” In this study using live mice, researchers observed that during hair follicle regression, apoptosis in basal cells may propagate by triggering neighboring cells, potentially regulated by a gradient of pro-survival signals from stem cells, and proposed a testable mechanism to further explore this process.
7 citations
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January 2016 in “Methods in molecular biology” This study describes the process of isolating and analyzing multipotent stem cells from mouse hair follicles for potential use in tissue engineering and regenerative medicine.
19 citations
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November 2018 in “Experimental Dermatology” This review explores the skin regeneration process in spiny mice and highlights differences from laboratory mice, focusing on potential molecular and immune system roles without reporting new experimental results.