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The Rotterdam Study updated its design and objectives in 2012, providing insights into various diseases in the elderly, including skin cancer, bone health, liver disease, neurological and psychiatric conditions, and respiratory issues.

The skin is a complex barrier for drug penetration, but understanding its structure and interactions can improve drug delivery methods.

Stress stops hair growth in mice by causing early hair growth phase end and harmful inflammation through a specific nerve-related pathway.

Demodicosis is common and often missed, needing more recognition and treatment in skin care.

Androgens can cause hair growth in some areas and hair loss on the scalp.

Superficial granulomatous pyoderma is a unique, mild form of skin disease that often heals without strong medication and responds well to milder treatments.

Lupus affects the body and skin, causing joint pain and skin issues that can be treated with steroids and antimalarial drugs.

Liposomes improve drug delivery and reduce skin irritation in dermatology.

Fat-derived stem cells show promise for skin repair and reducing aging signs but need more research for consistent results.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

Early detection and intensive treatment of diseases caused by Staphylococcus aureus toxins are crucial for reducing severe health effects.

Particles around 100 nm can penetrate and stay in hair follicles without passing through healthy skin, making them safe for use in topical products and useful for targeted drug delivery.

Wnt and Notch signaling help wound healing by promoting cell growth and regulating cell differentiation.

Liposomes could improve how skin care products work but are costly and not very stable.

ICG-enhanced NIR laser therapy may be a promising acne treatment with improvement and no side effects.

Mice without the vitamin D receptor gene lose hair due to disrupted hair follicle cycles.

Platelet-rich plasma may help in skin and hair treatments, and with muscle and joint healing, but more research is needed to fully understand its benefits and limitations.

Toxic epidermal necrolysis is a severe skin condition often caused by drugs, with complex treatment and a high risk of death, but survivors usually heal without scars.

Acne is caused by genetics, diet, hormones, and bacteria, with treatments not yet curative.

Advanced nanocarrier and microneedle drug delivery methods are more effective, safer, and less invasive for treating skin diseases.

Hirsutism is excessive hair growth in women often caused by polycystic ovarian syndrome, and identifying the cause is important for managing associated health risks.

European guidelines recommend regular eye and ear exams, skin care, vitamin D supplements, and cautious use of medications for managing congenital ichthyoses.

Some systemic treatments work for nail psoriasis but can have serious side effects.

Malnutrition severely harms growth and development in young baboons.

Human amniotic membrane helps heal skin wounds faster and with less scarring.

Fractional laser resurfacing is effective and safe for skin treatment, with benefits like less downtime and a low risk of adverse events.

Microneedle arrays with nanotechnology show promise for painless drug delivery through the skin but need more research on safety and effectiveness.

VYC-15L is a safe and effective lip filler that lasts up to a year.

The conclusion is that we need more effective hair loss treatments than the current ones, and these could include new drugs, gene and stem cell therapy, hormones, and scalp cooling, but they all need thorough safety testing.

Plant-based ingredients are effective and safe for modern skincare products.