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This study found that Piezo2 channels are primarily located on sensory axon membranes in mechanosensory end organs, supporting a model where mechanical stimuli activate Aβ RA-LTMR neurons via axon protrusions.

This review discusses the role of multiomics in understanding skin repair and regeneration mechanisms and reports no new results; the authors suggest it may lead to personalized medicine advancements and improved treatments.

This study systematically compared pediatric and adult Cushing's disease patients, revealing more severe and earlier-onset symptoms in males, and distinct gender-specific clinical manifestations.

This systematic review synthesizes the current state of drug repurposing, revealing its potential in various therapeutic areas like oncology and infectious diseases through insights from mechanistic studies and real-world evidence, and discusses emerging tools and challenges in the field.

This study concluded that the GIANT brain atlas, which integrates genetic and neuroanatomical variations, provides a more accurate representation of brain structure than traditional neuroanatomical atlases, allowing for better exploration of genetic influences on the brain.

Among families with pediatric brain disease, this study identified over 200 novel genetic causes, revealing potential treatment points using drug repurposing or nutritional supplementation.

This review highlights that nanotechnology enhances the solubility, stability, and bioavailability of phytochemicals from medicinal plants, improving their therapeutic efficiency in disease models like cancer and infections. However, it indicates that further research is necessary to optimize formulations and ensure safety for clinical use.

This study explores the complex mechanisms of skin aging, including cellular senescence and disrupted communication, and highlights rejuvenation strategies like gene expression rewiring and microbiome modulation, offering potential frameworks for regenerative therapies and precise interventions in skin and systemic aging.

This study found that VPS13C variants are significantly enriched in patients with idiopathic REM sleep behavior disorder (iRBD), associating these variants with more severe symptoms, autonomic dysfunction, and faster progression from iRBD to overt α-synucleinopathy in the iRBD-first disease subtype.

In a conditional knockout mouse model, this study found that loss of the transcription elongation factor SPT6 in basal keratinocytes led to psoriasis-like skin inflammation and delayed wound healing, suggesting SPT6 plays a crucial role in maintaining epidermal immune quiescence by suppressing proinflammatory NF-κB signaling.

This study found that a mesenchymal stromal cell-derived regenerative extracellular matrix (rECM) significantly accelerated wound closure and improved healing in diabetic mice, also enhancing nerve and blood vessel formation compared to controls.

In this review, researchers detail how immunosenescence and chronic neuroinflammation contribute to Parkinson's disease progression, exploring potential therapeutic strategies targeting this axis, such as senolytic agents and immune rejuvenation, while highlighting associated challenges and future research needs.

Natural products might help treat hair greying.

This study found that combining shikimic acid with Prunus mume fruit extract significantly reduces type I 5α-reductase levels in testosterone-stressed skin sebocytes, surpassing the effects of shikimic acid or standard acne treatments alone, and shows promise for stable, non-irritating acne remedies in cosmetic formulations.

This study introduced ElixirSeeker2, a computational framework for designing anti-aging peptides, and found that some newly identified peptides significantly delayed cellular senescence and enhanced cellular and locomotor functions in aged Caenorhabditis elegans.

This study found that patients with tropical chronic pancreatitis exhibited significantly reduced plasma amino acid levels and antioxidant capacity, with folate deficiency identified as a key factor in hyperhomocysteinemia.

This review highlights recent advances in dermatology, including innovations in skin cancer treatments, acne and psoriasis management, trends in cosmetic procedures, and the impact of telemedicine, emphasizing ongoing research's role in enhancing patient care and outcomes.

This book reviews the symptoms, diagnosis, and treatments for Polycystic Ovary Syndrome, providing a comprehensive exploration but reports no new clinical results.

This study observed that topical application of maslinic acid stimulated hair growth in mice comparably to minoxidil, possibly through the Wnt/β-catenin pathway and involving ciliary gene activity, highlighting increased levels of trichogenic gene expression and protein levels.

In this study, researchers observed that individuals with alopecia areata exhibited significant changes in scalp microbiota diversity and composition, which were linked to disease severity and inflammation markers, though it remains unclear if these microbial shifts are a cause or a result of hair loss.

This abstract does not provide study results but outlines that acne is influenced by factors like androgens, sebum production, abnormal keratinization, and inflammatory reactions involving lymphocytes, macrophages, and neutrophils.

This study aims to use a comprehensive health data set to develop a statistical model that can improve personalized and preventive health care by understanding relationships between various health parameters in individuals.

This review examines the evolving field of nanozymes, highlighting their unique properties and biocatalytic capabilities that challenge traditional concepts of biocatalysis, with implications for sustainable applications and potential roles in physiological processes and disease pathogenesis.

This article discusses the rationale, design, and significant findings of the long-running Rotterdam Study but reports no new clinical results.

This article outlines the rationale and design of the Rotterdam Study, summarizes its major findings, and updates its objectives and methods; it reports no new research results.

This article outlines the rationale, design, major findings, and updated objectives of the ongoing Rotterdam Study, without presenting new research data.

This article discusses the rationale, design, major findings, and updated objectives and methods of the ongoing Rotterdam Study on various diseases, without reporting new research results.

This review examines hair cosmetics, including shampoos and conditioners, for their formulations and effects, but reports no new clinical findings; it emphasizes the importance of dermatologist knowledge in treating diverse hair conditions.

This review discusses the use of 36 medicinal plant species for cutaneous wound healing and reports no new clinical results; the authors highlight the potential for these traditional practices to inform modern therapies.

This review discusses the effects of testosterone therapy for transgender men, noting desired outcomes and potential risks, but reports no new research findings; the authors highlight a lack of high-quality data due to various study limitations.